[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521096":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":45,"responsibleParty":247,"collaborators":249,"id":252,"slug":253,"hasResults":254,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":254,"sex":260,"minAge":261,"maxAge":25,"enrollmentInfo":262,"targetDuration":25,"studyType":265,"phases":266,"briefSummary":268,"conditions":269,"keywords":25,"overallStatus":66,"whyStopped":25,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":280},{"fullName":5,"class":6},"University Hospital, Angers","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard support","ACTIVE_COMPARATOR","Initial medical treatment: placement of a nasogastric tube associated with hydration and vascular filling for hypovolaemic patients. Other medical treatments for occlusive small bowel syndrome on adhesion or flange can be performed but are not systematically recommended. Their use is left to the discretion of the surgeon. Medical treatment is carried out over 72 hours from admission.\n\nIn case of resumption of a transit by gas and\u002For stools associated with a tolerance to the food, the exit is authorized without resorting to surgery. In the absence of a resumption of transit by gas and\u002For stools associated with tolerance to food, semi-urgent surgical management is proposed 72 hours from the start of management. In the event of deterioration of the clinical condition during hospitalization, urgent surgery will be proposed, according to the recommendations for use.",[13],"Procedure: Standard support",{"label":15,"type":16,"description":17,"interventionNames":18},"Early surgery proposed according to the radiological score","EXPERIMENTAL","Patients included in the experimental arm have treatment adapted to the radiological score. The radiological score described by Berge et al. (Berge et al. Eur J Trauma Emerg Surg 2021) is calculated after patient inclusion.",[19],"Procedure: Early surgery proposed according to the radiological score",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","See arm\u002Fgroup descriptions",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"* If score ≥ 5: the risk of medical treatment failure is multiplied by 2.9 (Feuerstoss F et al, J Gastrointest Surg 2021). Early surgical treatment is proposed; that is, the procedure is performed within 24 hours of admission. The surgery is initiated by laparoscopy and converted to open surgery if necessary.\n* If score \\\u003C 5: the risk of medical treatment failure is reduced. Initial medical treatment is therefore offered in accordance with standard management.",[15],[30],{"name":31,"affiliation":32,"role":33},"Cécile Jaglin-Grimonprez","University hospital of Angers","STUDY_DIRECTOR",[35,41],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Paul Le Naoures, Dr","CONTACT","(0)2 41 35 49 16","33","Paul.LeNaoures@chu-angers.fr",{"name":42,"role":37,"phone":43,"phoneExt":39,"email":44},"Aurélien Vénara, Pr","(0)2 41 35 36 18","AuVenara@chu-angers.fr",[46,64,79,93,107,121,135,149,163,177,191,205,219,233],{"facility":47,"status":48,"city":49,"state":25,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"University Hospital of Amiens","NOT_YET_RECRUITING","Amiens","80054","France","FR",{"type":54,"coordinates":55},"Point",[56,57],2.3,49.9,{"lat":57,"lon":56},[60],{"name":61,"role":37,"phone":62,"phoneExt":39,"email":63},"Jean-Marc REGIMBEAU, Pr","3 22 08 89 00","regimbeau.jean-marc@chu-amiens.fr",{"facility":65,"status":66,"city":67,"state":25,"zip":68,"country":51,"countryCode":52,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"University Hospital of Angers","RECRUITING","Angers","49933",{"type":54,"coordinates":70},[71,72],-0.55202,47.47156,{"lat":72,"lon":71},[75],{"name":76,"role":37,"phone":77,"phoneExt":39,"email":78},"Aurélien VENARA, Pr","2 41 35 49 16","aurelien.venara@chu-angers.fr",{"facility":80,"status":48,"city":81,"state":25,"zip":82,"country":51,"countryCode":52,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"University Hospital of Brest","Brest","29609",{"type":54,"coordinates":84},[85,86],-4.48628,48.39029,{"lat":86,"lon":85},[89],{"name":90,"role":37,"phone":91,"phoneExt":39,"email":92},"Bogdan BADIC, Pr","2 98 34 72 35","bogdan.badic@chu-brest.fr",{"facility":94,"status":66,"city":95,"state":25,"zip":96,"country":51,"countryCode":52,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"University Hospital of Tours","Chambray-lès-Tours","37170",{"type":54,"coordinates":98},[99,100],0.70286,47.33537,{"lat":100,"lon":99},[103],{"name":104,"role":37,"phone":105,"phoneExt":39,"email":106},"Mehdi OUAISSI, Pr","2 18 37 05 75","m.ouaissi@chu-tours.fr",{"facility":108,"status":48,"city":109,"state":25,"zip":110,"country":51,"countryCode":52,"cosmosGeoPoint":111,"geoPoint":115,"contacts":116},"Hospital of Haut Anjou","Château-Gontier","53200",{"type":54,"coordinates":112},[113,114],-0.70512,47.82705,{"lat":114,"lon":113},[117],{"name":118,"role":37,"phone":119,"phoneExt":39,"email":120},"Marine SARFATI-LEBRETON, DR","2 43 09 33 55","Marine.SarfatiLebreton@chu-angers.fr",{"facility":122,"status":48,"city":123,"state":25,"zip":124,"country":51,"countryCode":52,"cosmosGeoPoint":125,"geoPoint":129,"contacts":130},"University Hospital of Dijon Bourgogne","Dijon","21000",{"type":54,"coordinates":126},[127,128],5.01391,47.31344,{"lat":128,"lon":127},[131],{"name":132,"role":37,"phone":133,"phoneExt":39,"email":134},"Pablo ORTEGA DEBALLON, Pr","3 80 29 37 47","pablo.ortega-deballon@chu-dijon.fr",{"facility":136,"status":66,"city":137,"state":25,"zip":138,"country":51,"countryCode":52,"cosmosGeoPoint":139,"geoPoint":143,"contacts":144},"University Hospital of Grenoble-Alpes","Grenoble","38043",{"type":54,"coordinates":140},[141,142],5.71479,45.17869,{"lat":142,"lon":141},[145],{"name":146,"role":37,"phone":147,"phoneExt":39,"email":148},"Edouard GIRARD, Dr","4 76 76 54 65","egirard1@chu-grenoble.fr",{"facility":150,"status":66,"city":151,"state":25,"zip":152,"country":51,"countryCode":52,"cosmosGeoPoint":153,"geoPoint":157,"contacts":158},"Hospital of Vendée","La Roche-sur-Yon","85925",{"type":54,"coordinates":154},[155,156],-1.42757,46.66974,{"lat":156,"lon":155},[159],{"name":160,"role":37,"phone":161,"phoneExt":39,"email":162},"Emeric ABET, Dr","2 51 44 61 61","emeric.abet@ght85.fr",{"facility":164,"status":48,"city":165,"state":25,"zip":166,"country":51,"countryCode":52,"cosmosGeoPoint":167,"geoPoint":171,"contacts":172},"University Hospital of Montpellier","Montpellier","34295",{"type":54,"coordinates":168},[169,170],3.87635,43.61093,{"lat":170,"lon":169},[173],{"name":174,"role":37,"phone":175,"phoneExt":39,"email":176},"François-Régis SOUCHE, Pr","4 67 33 70 72","fr-souche@chu-montpellier.fr",{"facility":178,"status":48,"city":179,"state":25,"zip":180,"country":51,"countryCode":52,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"University Hospital of Nantes","Nantes","44093",{"type":54,"coordinates":182},[183,184],-1.55336,47.21725,{"lat":184,"lon":183},[187],{"name":188,"role":37,"phone":189,"phoneExt":39,"email":190},"Emilie DUCHALAIS, Dr","2 40 08 33 33","emilie.duchalais@chu-nantes.fr",{"facility":192,"status":48,"city":193,"state":25,"zip":194,"country":51,"countryCode":52,"cosmosGeoPoint":195,"geoPoint":199,"contacts":200},"University Hospital of Nice","Nice","06000",{"type":54,"coordinates":196},[197,198],7.26608,43.70313,{"lat":198,"lon":197},[201],{"name":202,"role":37,"phone":203,"phoneExt":39,"email":204},"Damien MASSALOU, Dr","4 92 03 77 77","massalou.d@chu-nice.fr",{"facility":206,"status":48,"city":207,"state":25,"zip":208,"country":51,"countryCode":52,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"University Hospital of Lyon","Pierre-Bénite","69495",{"type":54,"coordinates":210},[211,212],4.82424,45.70359,{"lat":212,"lon":211},[215],{"name":216,"role":37,"phone":217,"phoneExt":39,"email":218},"Guillaume PASSOT, Pr","4 78 86 23 71","guillaume.passot@chu-lyon.fr",{"facility":220,"status":48,"city":221,"state":25,"zip":222,"country":51,"countryCode":52,"cosmosGeoPoint":223,"geoPoint":227,"contacts":228},"University Hospital of Rennes","Rennes","35033",{"type":54,"coordinates":224},[225,226],-1.67431,48.11109,{"lat":226,"lon":225},[229],{"name":230,"role":37,"phone":231,"phoneExt":39,"email":232},"Fabien ROBIN, Dr","2 99 28 90 37","Fabien.ROBIN@chu-rennes.fr",{"facility":234,"status":48,"city":235,"state":25,"zip":236,"country":51,"countryCode":52,"cosmosGeoPoint":237,"geoPoint":241,"contacts":242},"University Hospital of Strasbourg","Strasbourg","67098",{"type":54,"coordinates":238},[239,240],7.74553,48.58392,{"lat":240,"lon":239},[243],{"name":244,"role":37,"phone":245,"phoneExt":25,"email":246},"Cécile BRIGAND, Pr","3 88 12 72 26","cecile.brigand@chru-strasbourg.fr",{"type":248,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[250],{"name":251,"class":6},"Direction Générale de l'Offre de Soins","100521096","early-surgery-versus-3-days-non-surgical-management-in-acute-small-bowel-obstruction-surgi-bow-100521096",false,"NCT06065150","Early Surgery Versus 3 Days Non-surgical Management in Acute Small Bowel Obstruction (SURGI-BOW)","SURGI-BOW - Early Surgery Versus 3 Days Non-surgical Management in Acute Small Bowel Obstruction: a Randomized Open-label Controlled Study","SURGI-BOW","Inclusion Criteria:\n\n* Admission for acute intestinal obstruction of the small intestine on adhesion or bridle\n* Confirmation of the aSBO by a scanner\n* Adult patient\n* Beneficiary of a social security scheme\n* Having signed an informed consent\n\nExclusion Criteria:\n\n* Indication for urgent surgery (small intestine ischemia, intestinal pain, defence, hemodynamic shock, etc.)\n* Pregnancy or breastfeeding\n* Poor understanding of the French language\n* Person deprived of liberty by judicial or administrative decision\n* Person undergoing psychiatric treatment under duress\n* Person subject to a legal protection measure\n* Person unable to express consent","ALL","18 Years",{"count":263,"type":264},630,"ESTIMATED","INTERVENTIONAL",[267],"NA","For uncomplicated acute small bowel obstruction (aSBO), the \"Bologna guidelines\" recommend non-surgical management of 72 hours before considering surgery. This treatment is based on the placement of a nasogastric tube and the correction of hydro-electrolyte disorders. Non-surgical management is only effective in 60 to 70% and surgery is therefore necessary in 30 to 40% of cases after medical treatment for at least 3 days. This therefore leads to an increase in the length of hospital stay. Some authors also point out that postponing surgery for 3 days would aggravate the morbidity and mortality of surgery. Indeed, aSBO surgery has a complication rate of 10-40% and a mortality of up to 4%.\n\nThere is a lack of studies evaluating what is the best management strategy for aSBO, especially with regard to the duration of medical treatment. Many recent studies plead in favor of early surgical treatment (\\\u003C24 hours) which would reduce the morbidity and mortality rate of surgery but also the overall cost of treatment by reducing the length of stay.\n\nThis paradigm shift is linked to the improvement of anesthetic and intensive care management over the last few years, but also to the advent of laparoscopy in emergency surgery. Indeed, laparoscopy could reduce the duration of hospitalization but also the operative morbidity and mortality. However, this surgical approach is not feasible in all situations and the conversion rate is reported in 30 to 76% of cases. One of the factors favoring the feasibility of the laparoscopic approach is the performance of early surgery.\n\nAnother parameter favoring the feasibility of the laparoscopic approach is the aSBO mechanism: an aSBO on flange (SBA) is more likely to be treated effectively by laparoscopic than an aSBO on multiple adhesions (MA).\n\nIn the literature, there is little to differentiate SBAs from MAs. Advances in CT scans have made it possible to describe the signs associated with the SBA mechanism and then to propose a score making it possible to predict the SBA mechanism with good performance (sensitivity 67.6%, specificity 84.6%). This score not only has the advantage of predicting the mechanism of the occlusion but it also makes it possible to predict the failure of non-surgical treatment if the score is ≥5.",[270],"Small Bowel Obstruction","2024-06-12",{"date":273,"type":274},"2024-06-13","ACTUAL",{"date":276,"type":274},"2024-01-30",{"date":278,"type":264},"2028-01-29",{"name":5,"class":6},14]