[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549758":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":44,"collaborators":19,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":19,"enrollmentInfo":57,"targetDuration":19,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":32,"whyStopped":19,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Erasmus Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Mechanically ventilated adults","EXPERIMENTAL","Switch from controlled to assisted mechanical ventilation when PaO2\u002FFiO2-ratio \\> 200 mmHg.\n\nBefore switch (on controlled ventilation) participants will undergo an electrical impedance tomography (EIT) perfusion measurement as well as a photon-counting CT (PCCT) scan to assess lung perfusion and ventilation\u002Fperfusion mismatch. From 15 minutes before until 4 hours after switch and 30 minutes twice daily for 72 hours or until switch failure participants will be monitored continuously using EIT, esophageal pressure and gastric pressure.",[13],"Other: Pre-specified switch from controlled to assisted ventilation when PaO2\u002FFiO2-ratio > 200 mmHg",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Pre-specified switch from controlled to assisted ventilation when PaO2\u002FFiO2-ratio > 200 mmHg","A pre-specified switch from controlled to assisted ventilation will be initiated when PaO2\u002FFiO2-ratio \\> 200 mmHg. The moment of switch is pre-specified but patient management and ventilator settings are up to the clinical team. Switch is complete when the patient triggers all breaths spontaneously. Switch success is defined if patient reaches 72 hours on assisted ventilation. Switch failure is defined if patient switches back to controlled ventilation for more than 2 hours before 72 hours.",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Annemijn Jonkman, PhD","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":19,"email":28},"CONTACT","+3110-7035142","a.jonkman@erasmusmc.nl",[30],{"facility":31,"status":32,"city":33,"state":19,"zip":19,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Erasmus MC","RECRUITING","Rotterdam","Netherlands","NL",{"type":37,"coordinates":38},"Point",[39,40],4.47917,51.9225,{"lat":40,"lon":39},[43],{"name":22,"role":26,"phone":19,"phoneExt":19,"email":19},{"type":23,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Annemijn Jonkman","Assistant Professor","100549758","early-switch-from-controlled-to-assisted-ventilation-100549758",false,"NCT06438198","Early Switch from Controlled to Assisted Ventilation","Unraveling the (patho)physiological Mechanisms and Potential Clinical Benefits of an Early Switch from Controlled to Assisted Ventilation","SWITCH-SAFE","Inclusion Criteria:\n\n* 18 years old\n* Written informed consent from a legal representative\n* Mechanical ventilation via an endotracheal tube\n* Acute hypoxemic respiratory failure with PaO2\u002FFiO2 ratio \\\u003C 200 mmHg\n* Under continuous sedation with or without paralysis\n\nExclusion Criteria:\n\n* Expected mechanical ventilation duration of \\\u003C48 hours\n* Pure chronic obstructive pulmonary disease exacerbation\n* Pre-existent respiratory muscle disease\n* Contraindication to EIT monitoring (as per clinical protocol, e.g. pacemaker, burns or thoracic wounds limiting electrode placement)\n* Contra-indications to oesophageal manometry (as per clinical protocol, e.g., recent oesophageal surgery, oesophageal varices, severe bleeding disorders)\n* Known pregnancy\n* Anticipating withdrawal of life support and\u002For shift to palliation as the goal of care","ALL","18 Years",{"count":58,"type":59},20,"ESTIMATED","INTERVENTIONAL",[62],"NA","The goal of this physiological intervention study is to unravel the (patho)physiological mechanisms and potential clinical benefits of a pre-specified early switch from controlled to assisted ventilation in mechanically ventilated adult patients with acute hypoxemic respiratory failure (PaO2\u002FFiO2 ratio \\\u003C 200 mmHg).\n\nThe intervention is that participants will be switched from controlled to assisted ventilation when PaO2\u002FFiO2 ratio \\> 200 mmHg.\n\nThe primary endpoint is the change in regional lung stress (as derived by electrical impedance tomography) when switching from controlled to assisted ventilation and until a successful or failed switch.",[65,66],"Acute Hypoxemic Respiratory Failure","Mechanical Ventilation",[68,69,70,71,72],"Electrical Impedance Tomography","Esophageal manometry","Controlled Mechanical Ventilation","Assisted Mechanical Ventilation","Respiratory Monitoring","2024-10-16",{"date":75,"type":76},"2024-10-18","ACTUAL",{"date":78,"type":76},"2024-09-15",{"date":80,"type":59},"2026-05",{"name":5,"class":6},1]