[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643764":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":28,"centralContacts":45,"locations":51,"responsibleParty":68,"collaborators":28,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":28,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":28,"maxAge":28,"enrollmentInfo":78,"targetDuration":28,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":54,"whyStopped":28,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University Hospital, Antwerp","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Eccentric strength training + cardio","EXPERIMENTAL","45 sessions experimental protocol",[13,14,15],"Other: eccentric bike training","Other: eccentric overload training","Other: aerobic treadmill training",{"label":17,"type":18,"description":19,"interventionNames":20},"Traditional strength training + cardio","ACTIVE_COMPARATOR","45 sessions traditional cardiac rehabilitation",[15,21,22],"Other: aerobic bike training","Other: traditional dynamic strength training",[24,29,33,37,41],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"eccentric bike training","progressive following protocol, 10min",[9],null,{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":28},"eccentric overload training","dynamic strength training + eccentric overload, progressive over time, 3sets\\*10reps (15-20min)",[9],{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":28},"aerobic treadmill training","aerobic training, progressive over time, 10 min",[9,17],{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":28},"aerobic bike training","aerobic training, progressive following protocol, 10 min",[17],{"type":6,"name":42,"description":43,"armGroupLabels":44,"otherNames":28},"traditional dynamic strength training","dynamic strength training, progression over time, 15-20 min",[17],[46],{"name":47,"role":48,"phone":49,"phoneExt":28,"email":50},"Wendy Hens, PhD","CONTACT","0032 3 275 73 89","wendy.hens@uza.be",[52],{"facility":53,"status":54,"city":55,"state":28,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"UHAntwerp","RECRUITING","Edegem","2850","Belgium","BE",{"type":60,"coordinates":61},"Point",[62,63],4.44504,51.15662,{"lat":63,"lon":62},[66,67],{"name":47,"role":48,"phone":49,"phoneExt":28,"email":50},{"name":28,"role":48,"phone":28,"phoneExt":28,"email":50},{"type":69,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100643764","eccentric-muscle-training-in-cardiac-rehabilitation-100643764",false,"NCT07636343","Eccentric Muscle Training in Cardiac Rehabilitation","Eccentric Muscle Training in Cardiac Rehabilitation: Randomized Controlled Trial to Evaluate Effectiveness and Feasibility in Heart Failure Patients With Reduced Ejection Fraction","Inclusion Criteria:\n\n* HFrEF patients with ejection fraction \\\u003C40%\n* Exercise intolerance (\\\u003C85% of predicted VO2 peak)\n* clinically stable for \\> 6 weeks, optimal medical treatment for \\> 6 weeks\n\nExclusion Criteria:\n\n* Contra indications for cardiac exercise rehabilitation as per consensus guidelines and recommendations\n* Musculoskeletal disorders that hamper (progression in) strength training\n* Non-stabilized acute coronary syndrome\n* Current acute heart failure (decompensation)\n* Patient having sustained a recent (\\\u003C3 months) procedure that could act as a confounder to increase VO2peak (i.e., coronary artery bypass graft surgery, percutaneous coronary intervention, cardiac resynchronization therapy, valve surgery or reparation)","ALL",{"count":79,"type":80},3,"ESTIMATED","INTERVENTIONAL",[83],"NA","The goal of this interventional study is to assess the training effects in a training schedule in which eccentric overload training and eccentric cycle training are used.\n\nResearchers will compare a training program of eccentric overload training and eccentric cycling training with a traditional training program of strength and cardio training in people with heart failure with reduced ejection fraction.\n\nThis study will be delivered in a cardiac rehabilitation setting.",[86,87],"Strength Training Effects","HFrEF - Heart Failure With Reduced Ejection Fraction",[89],"eccentric muscle training","2026-06-03",{"date":92,"type":93},"2026-06-09","ACTUAL",{"date":95,"type":93},"2023-01-20",{"date":97,"type":80},"2027-01-01",{"name":5,"class":6},1]