[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584644":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":46,"responsibleParty":77,"collaborators":26,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":26,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":26,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":49,"whyStopped":26,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Wave Neuroscience","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active eTMS treatment","ACTIVE_COMPARATOR","15 treatment days of EEG-based personalized TMS over a maximum of 28 days. Two sessions per treatment day. Each session consists of TMS treatment at 80% Motor Threshold, pulse frequency between 8-13 Hz. TMS delivery of 5 second pulse train, with an inter-train interval of 20 seconds. Session duration is 15 minutes. A rest period of at least 30 minutes is required between the 2 sessions in a treatment day.",[13],"Device: EEG-based personalized TMS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham eTMS Treatment","SHAM_COMPARATOR","15 treatment days of sham EEG-based personalized TMS over a maximum of 28 days. Two sessions per treatment day. Each session consists of sham TMS treatment. TMS delivery of 5 second pulse train, with an inter-train interval of 20 seconds. Session duration is 15 minutes. A rest period of at least 30 minutes is required between the 2 sessions in a treatment day.",[19],"Device: Sham Comparator",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","EEG-based personalized TMS","Transcranial Magnetic Stimulation (TMS), in which treatment is personalized based on the participant's Electroencephalogram (EEG)",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham Comparator","Sham Transcranial Magnetic Stimulation (TMS), in which treatment is personalized based on the participant's Electroencephalogram (EEG). No stimulation is provided.",[15],[32],{"name":33,"affiliation":34,"role":35},"Bill Phillips, PhD","Wave Neuroscience, Inc.","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Matthew Sherwood, PhD","CONTACT","937-775-2342","msherwood@etmsfda.com",{"name":43,"role":39,"phone":44,"phoneExt":26,"email":45},"Walter Mysiw, MD","614-293-3433","coordinator@etmsfda.com",[47,66],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Wright State University","RECRUITING","Dayton","Ohio","45435","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-84.19161,39.75895,{"lat":59,"lon":58},[62],{"name":63,"role":39,"phone":64,"phoneExt":26,"email":65},"Matt Sherwood, PhD","937-524-3924","matt.sherwood@wright.edu",{"facility":67,"status":49,"city":68,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"D2 Human Performance Center","Pickerington",{"type":56,"coordinates":70},[71,72],-82.7535,39.88423,{"lat":72,"lon":71},[75],{"name":76,"role":39,"phone":40,"phoneExt":26,"email":45},"Erin Woodburn",{"type":78,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100584644","eeg-based-personalized-transcranial-magnetic-stimulation-etms-to-treat-post-traumatic-stress-disorder-100584644",false,"NCT06892028","EEG-based Personalized Transcranial Magnetic Stimulation (eTMS) to Treat Post-Traumatic Stress Disorder","A Randomized Controlled Trial of Electroencephalogram (EEG) Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder","Inclusion Criteria:\n\n* Willing and able to consent to participate in the study via signed Informed Consent\n* Age 22 - 65 years\n* Diagnosis of PTSD according to DSM-5 criteria via the Clinician-Administered PTSD Scale (CAPS).\n* Onset of symptoms meeting the DSM-5 criteria for PTSD symptoms persisting for a minimum of 6 months prior to the Screening Visit\n* Veterans Administration PCL-5 cut point score of 31 or above\n* Positive identification as either a Veteran, or First Responder (e.g., emergency medical service provider, firefighter, or any other emergency response personnel)\n\nExclusion Criteria:\n\n* Uncontrolled medical, psychological or neurological condition\n* Pregnant, or female unwilling to use effective birth control during the course of the trial\n* Metal objects in the head\n* Past exposure to metal fragments, permanent piercings, and\u002For other possible metal sources in the head and neck\n* Current participation in any interventional research protocol\n* History of any type of Electroconvulsive Therapy (ECT) or repetitive Transcranial Magnetic Stimulation (rTMS)\n* History of stroke or intracranial lesion or increased intracranial pressure\n* History of epilepsy of seizure\n* Family history of epilepsy or seizure in 1st degree relative\n* An elevated risk of suicide or violence to others","ALL","22 Years","65 Years",{"count":90,"type":91},110,"ESTIMATED","INTERVENTIONAL",[94],"NA","This is a randomized, sham controlled study of the Electroencephalogram (EEG) based Transcranial Magnetic Stimulation (eTMS) treatment for Post-Traumatic Stress Disorder (PTSD). The recruitment goal is 110 participants who are United States Military veterans or first responders (e.g., firefighters, police, paramedics, etc.). The Study includes an EEG recording in order to determine the optimal treatment parameters for the eTMS system, followed by 15 in-office visits that take place over 21-28 total days. Two eTMS treatment sessions are administered during each office visit.",[97],"Stress Disorder, Post Traumatic",[99,100,101],"PTSD","Veterans","First Responders","2025-03-17",{"date":104,"type":105},"2025-03-24","ACTUAL",{"date":107,"type":105},"2025-02-12",{"date":109,"type":91},"2026-01-31",{"name":5,"class":6},2]