[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100396547":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":40,"centralContacts":44,"locations":53,"responsibleParty":69,"collaborators":28,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":28,"enrollmentInfo":82,"targetDuration":28,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":94,"whyStopped":28,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Columbia University","OTHER",[8,15,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Maintenance-Alpha Optimization \u002F Wake from Dexmedetomidine","EXPERIMENTAL","During the first randomization, participants randomized to intraoperative oscillatory EEG alpha optimization will receive individualized titration of anesthetic gas and opioids.",[13,14],"Procedure: Alpha Optimization","Behavioral: Emergence from anesthesia with Dexmedetomidine",{"label":16,"type":17,"description":18,"interventionNames":19},"Maintenance-Alpha Optimization \u002F Wake from Sevoflurane","ACTIVE_COMPARATOR","During the first randomization, participants randomized to intraoperative oscillatory EEG alpha optimization will receive real-time monitoring of alpha recordings and individualized titration of desflurane and opioid. During the second randomization, participants randomized to standard emergence from volatile anesthesia will be woken up per standard practice.",[13],{"label":21,"type":17,"description":22,"interventionNames":23},"Maintenance-Routine Care \u002F Wake from Dexmedetomidine","During the first randomization, participants randomized to standard of care will receive anesthesia per usual care with quantitative processed EEG index values and EEG wave forms.",[14],{"label":25,"type":26,"description":27,"interventionNames":28},"Maintenance-Routine Care \u002F Wake from Sevoflurane","NO_INTERVENTION","During the first randomization, participants randomized to standard of care will receive anesthesia per usual care with quantitative processed EEG index values and EEG wave forms. During the second randomization, participants randomized to standard emergence from volatile anesthesia will be woken up per standard practice.",null,[30,35],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":28},"PROCEDURE","Alpha Optimization","Intraoperative oscillatory EEG alpha optimization involves real-time acquisition of oscillatory alpha power from the frontal EEG with individualized titration of sevoflurane and opioid.",[9,16],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":28},"BEHAVIORAL","Emergence from anesthesia with Dexmedetomidine","Infusion of .05 mcg\u002Fkg\u002Fh of propofol during the final 10-20 minutes of surgery.",[9,21],[41],{"name":42,"affiliation":5,"role":43},"Paul S. Garcia, MD, PhD","PRINCIPAL_INVESTIGATOR",[45,49],{"name":42,"role":46,"phone":47,"phoneExt":28,"email":48},"CONTACT","212-304-7678","pg2618@cumc.columbia.edu",{"name":50,"role":46,"phone":51,"phoneExt":28,"email":52},"Tuan Z. Cassim, BA","917-539-9926","tc3032@cumc.columbia.edu",[54],{"facility":55,"status":28,"city":56,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Columbia University Irving Medical Center","New York","10032","United States","US",{"type":61,"coordinates":62},"Point",[63,64],-74.00597,40.71427,{"lat":64,"lon":63},[67,68],{"name":42,"role":46,"phone":47,"phoneExt":28,"email":48},{"name":50,"role":46,"phone":51,"phoneExt":28,"email":52},{"type":43,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"Paul Garcia","Associate Professor of Anesthesiology","100396547","eeg-guided-analgesic-titration-during-general-anesthesia-to-improve-early-neurocognitive-recovery-in-older-patients-100396547",false,"NCT04443517","EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients","ALPHA-DEX","Inclusion Criteria:\n\n* Adults aged 60 years or over\n* Has capacity to provide informed consent\n* Undergoing elective non-cardiac surgery, which does not involve the head or neck, with planned volatile-based general anesthesia of expected duration of at least 2 hours\n\nExclusion Criteria:\n\n* Chronic pain with opioid requirement or concurrent use of enzyme inducers, e.g. carbamazepine, phenytoin,\n* Illicit substance use or excessive alcohol intake\n* Refusal by patient or case anesthesiologist responsible for patient's care",true,"ALL","60 Years",{"count":83,"type":84},600,"ESTIMATED","INTERVENTIONAL",[87],"NA","The investigators intend to recruit 600 participants to see if alpha power during anesthesia is influenced by analgesic medication and associated with a reduction of delirium following surgery.",[90],"Postoperative Delirium",[92,93],"EEG","General Anesthesia","NOT_YET_RECRUITING","2026-01-05",{"date":97,"type":98},"2026-01-07","ACTUAL",{"date":100,"type":84},"2026-04-01",{"date":102,"type":84},"2031-03-31",{"name":5,"class":6},1]