[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619718":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":201,"collaborators":10,"id":205,"slug":206,"hasResults":207,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":10,"eligibilityCriteria":211,"healthyVolunteers":207,"sex":212,"minAge":10,"maxAge":213,"enrollmentInfo":214,"targetDuration":10,"studyType":217,"phases":10,"briefSummary":218,"conditions":219,"keywords":221,"overallStatus":21,"whyStopped":10,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":233},{"fullName":5,"class":6},"Meyer Children's Hospital IRCCS","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Juvenile eosinophilic fasciitis",null,"Age \\\u003C 18 years at diagnosis\n\n\\- The study will include two different populations:\n\n1. Patients who have received a diagnosis of JEF based on deep fascial biopsy characteristics.\n2. Patients who have received a diagnosis of JEF based on typical MRI findings, but without performing a deep fascial biopsy.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Edoardo Marrani","CONTACT","+390555662913","edoardo.marrani@meyer.it",[19,33,43,54,69,79,92,104,116,126,140,154,166,175,189],{"facility":20,"status":21,"city":22,"state":23,"zip":24,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":10},"University of Alabama at Birmingham","RECRUITING","Birmingham","Alabama","35294","United States","US",{"type":28,"coordinates":29},"Point",[30,31],-86.80249,33.52066,{"lat":31,"lon":30},{"facility":34,"status":21,"city":35,"state":36,"zip":37,"country":25,"countryCode":26,"cosmosGeoPoint":38,"geoPoint":42,"contacts":10},"SUNY Upstate Pediatric Rheumatology","Syracuse","New York","13210",{"type":28,"coordinates":39},[40,41],-76.14742,43.04812,{"lat":41,"lon":40},{"facility":44,"status":21,"city":45,"state":10,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":53,"contacts":10},"Children's Hospital Zagreb","Zagreb","10000","Croatia","HR",{"type":28,"coordinates":50},[51,52],15.97798,45.81444,{"lat":52,"lon":51},{"facility":55,"status":56,"city":57,"state":10,"zip":10,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Hamburger Zentrum für Kinder- und Jugendrheumatologie -","NOT_YET_RECRUITING","Hamburg","Germany","DE",{"type":28,"coordinates":61},[62,63],9.99302,53.55073,{"lat":63,"lon":62},[66],{"name":67,"role":15,"phone":10,"phoneExt":10,"email":68},"Ivan Foldvari","foeldvari@t-online.de",{"facility":70,"status":56,"city":71,"state":10,"zip":10,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":78,"contacts":10},"Ruth Rappaport Children's Hospital of Haifa","Haifa","Israel","IL",{"type":28,"coordinates":75},[76,77],34.99928,32.81303,{"lat":77,"lon":76},{"facility":5,"status":21,"city":80,"state":81,"zip":82,"country":83,"countryCode":84,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Florence","FI","50139","Italy","IT",{"type":28,"coordinates":86},[87,88],11.24626,43.77925,{"lat":88,"lon":87},[91],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},{"facility":93,"status":21,"city":94,"state":10,"zip":10,"country":83,"countryCode":84,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"IRCCS Giannina Gaslini,","Genova",{"type":28,"coordinates":96},[97,98],11.87211,45.21604,{"lat":98,"lon":97},[101],{"name":102,"role":15,"phone":10,"phoneExt":10,"email":103},"Riccardo Papa","riccardo.papa@gaslini.it",{"facility":105,"status":56,"city":106,"state":10,"zip":10,"country":83,"countryCode":84,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"Università di Udine","Udine",{"type":28,"coordinates":108},[109,110],13.23715,46.0693,{"lat":110,"lon":109},[113],{"name":114,"role":15,"phone":10,"phoneExt":10,"email":115},"Giorgia Martini","giorgia.martini@uniud.it",{"facility":117,"status":21,"city":118,"state":10,"zip":10,"country":119,"countryCode":120,"cosmosGeoPoint":121,"geoPoint":125,"contacts":10},"Iuliu Hatieganu University of Medicine and Pharmacy","Cluj-Napoca","Romania","RO",{"type":28,"coordinates":122},[123,124],23.6,46.76667,{"lat":124,"lon":123},{"facility":127,"status":56,"city":128,"state":10,"zip":10,"country":129,"countryCode":130,"cosmosGeoPoint":131,"geoPoint":135,"contacts":136},"University Children's Hospital","Ljubljana","Slovenia","SI",{"type":28,"coordinates":132},[133,134],14.50513,46.05108,{"lat":134,"lon":133},[137],{"name":138,"role":15,"phone":10,"phoneExt":10,"email":139},"Natasa Toplak","natasa.toplak@kclj.si",{"facility":141,"status":56,"city":142,"state":10,"zip":10,"country":143,"countryCode":144,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"Hospital Sant Joan de Déu,","Barcelona","Spain","ES",{"type":28,"coordinates":146},[147,148],2.15899,41.38879,{"lat":148,"lon":147},[151],{"name":152,"role":15,"phone":10,"phoneExt":10,"email":153},"Joan Calzada Hernández","joan.calzada@sjd.es",{"facility":155,"status":21,"city":156,"state":157,"zip":158,"country":159,"countryCode":160,"cosmosGeoPoint":161,"geoPoint":165,"contacts":10},"Astrid Lindgren Children's Hospital","Solna","Stockholm County","17164","Sweden","SE",{"type":28,"coordinates":162},[163,164],18.00086,59.36004,{"lat":164,"lon":163},{"facility":167,"status":56,"city":168,"state":10,"zip":10,"country":169,"countryCode":10,"cosmosGeoPoint":170,"geoPoint":174,"contacts":10},"Cerrahpasa Medical School, Istanbul University","Istanbul","Turkey (Türkiye)",{"type":28,"coordinates":171},[172,173],28.94966,41.01384,{"lat":173,"lon":172},{"facility":176,"status":21,"city":177,"state":10,"zip":10,"country":178,"countryCode":179,"cosmosGeoPoint":180,"geoPoint":184,"contacts":185},"Alder Hey Children's Hospital","Liverpool","United Kingdom","UK",{"type":28,"coordinates":181},[182,183],-2.97794,53.41058,{"lat":183,"lon":182},[186],{"name":187,"role":15,"phone":188,"phoneExt":10,"email":188},"Clare Pain","Clare.Pain@alderhey.nhs.uk",{"facility":190,"status":56,"city":191,"state":10,"zip":10,"country":178,"countryCode":179,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"Great North Children's Hospital, Newcastle Upon Tyne","Newcastle upon Tyne",{"type":28,"coordinates":193},[194,195],-1.61396,54.97328,{"lat":195,"lon":194},[198],{"name":199,"role":15,"phone":10,"phoneExt":10,"email":200},"Miguel Bernardo","miguelbernardo.mb92@gmail.com",{"type":202,"investigatorFullName":203,"investigatorTitle":204,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Gabriele Simonini","MD","100619718","efeso-study-on-juvenile-onset-eosinophilic-fasciitis-100619718",false,"NCT07348263","EFESO: Study on Juvenile Onset Eosinophilic Fasciitis","International Multicentre Cohort Study on Clinical Manifestations and Response to Therapy in Juvenile Onset Eosinophilic Fasciitis","Inclusion criterai:\n\nAll patients diagnosed from 2000 to 31\u002F12\u002F2026\n\n* minimum follow-up 6 months\n* Age \\\u003C18 years at diagnosis;\n* All patients whose informed consent is collected in accordance with current local legislation will also be considered enrollable.\n\nExclusion Criteria:\n\n* Age ≥18 years at diagnosis;\n* Unwilling to participate into the study;\n* A follow-up period \\\u003C 6 months.","ALL","18 Years",{"count":215,"type":216},20,"ESTIMATED","OBSERVATIONAL","Eosinophilic fasciitis is a connective tissue disorder characterized by inflammation of the muscle fasciae, which is very rare in children. In juvenile-onset eosinophilic fasciitis (JEF), there may be severe joint involvement and skin manifestations may be less prevalent than in adults. It represents an important differential diagnosis of both juvenile-onset systemic sclerosis and localized scleroderma, and the correct classification of these patients is necessary to define a targeted diagnostic-therapeutic pathway. The diagnostic criteria proposed for eosinophilic fasciitis in the adult population do not necessarily require confirmation by skin biopsy, currently the \"gold standard,\" which is an invasive procedure for pediatric patients; however, these criteria have never been directly applied to the pediatric population. From a therapeutic point of view, the combination of glucocorticoids and methotrexate is recommended for both adults and pediatric patients, but the data supporting this treatment in children are very limited, and there are no studies comparing the therapeutic approaches currently in use in pediatrics. Finally, there are no studies in the literature documenting the long-term prognosis of these patients in terms of functional limitations, quality of life, or complications related to the disease or treatments.",[220],"Eosinophilic Fasciitis",[220,9,222,223],"juvenile scleroderma","sclerosing disorders","2026-03-09",{"date":226,"type":227},"2026-03-11","ACTUAL",{"date":229,"type":227},"2025-05-15",{"date":231,"type":216},"2027-05-15",{"name":5,"class":6},15]