[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100527403":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":30,"responsibleParty":45,"collaborators":30,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":30,"enrollmentInfo":59,"targetDuration":30,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":30,"overallStatus":68,"whyStopped":30,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":30},{"fullName":5,"class":6},"The University of Hong Kong","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Study Group","EXPERIMENTAL","Alveolar ridge preservation with Alb-PRF + A-PRF after extraction",[13],"Procedure: Study Group",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","PLACEBO_COMPARATOR","Spontaneous healing after extraction",[19],"Procedure: Control Group",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","The tooth will be extracted automatically, tooth sectioning will be performed if necessary for multi-rooted teeth to minimize trauma. Alveolar ridge preservation with blood platelet concentrate: heat-treated albumin (Alb-PRF) and advanced platelet-rich fibrin. The experimental site will be filled with A-PRF plugs\u002Fmembranes until level flushed with the level of bone. An additional Alb-PRF membrane will be tucked and inserted below the buccal and oral flap. Surgical flaps will not be raised. Soft tissue will be tunnelled and undermined for insertion of the Alb-PRF membrane. The extraction site and membranes will be stabilized by cross-mattress sutures and allowed for secondary intention healing.",[9],[26],"Albumin-platelet rich fibrin, Advanced platelet rich fibrin",{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"The tooth will be extracted automatically, tooth sectioning will be performed if necessary for multi-rooted teeth to minimize trauma. Cross mattress suture will be applied and site allowed to heal naturally.",[15],null,[32],{"name":33,"affiliation":5,"role":34},"Melissa Fok","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":30,"email":40},"Melissa R Fok","CONTACT","2859 0495","melfok@hku.hk",{"name":42,"role":38,"phone":43,"phoneExt":30,"email":44},"Catherine Mok","2859 0301","cathmok@hku.hk",{"type":34,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Dr. Melissa Fok","Clinical Assistant Professor","100527403","effect-alb-prf--a-prf-in-alveolar-ridge-preservation-in-diabetes-patients---a-rcct-100527403",false,"NCT06147310","Effect Alb-PRF & A-PRF in Alveolar Ridge Preservation in Diabetes Patients - A RCCT","Effect of Albumin Gel-platelet-rich Fibrin (Alb-PRF) and Advanced Platelet-rich Fibrin (A-PRF) in Alveolar Ridge Preservation in Diabetes Patients - A Randomized Controlled Clinical Trial","AlbPRFARP","i. At least 18 years old with established TIIDM diagnosis for more than 0.5 years, fasting blood glucose ≥7.0 mmol\u002FL or 2 h plasma glucose ≥11.1 mmol\u002FL, maximum HbA1c levels under 8.0%.\n\nii. Non-smoker, diagnosed with generalized periodontitis stage III or IV. iii. Need for extraction of teeth, on opposing arches or opposing sides, with or without other concurrent indications for extractions: orthodontics, periodontitis, caries, fracture, root resorption, unrestorable root fragments.\n\niv. At least one adjacent teeth\u002F implant is present at the site of extraction with a secure prognosis.\n\nv. No periapical lesions with a diameter of more than 5 mm (radiographically determined.\n\nvi. Extraction socket with a bone height of at least 7mm at 2 walls. vii. Reasonably aligned dental arches viii. Will consider implant to replace missing teeth ix. Willing and able to give informed consent.\n\nExclusion Criteria:\n\ni. Patients with conditions or circumstances, in the opinion of the Investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance or unreliability.\n\nii. Pregnancy or intention to become pregnant at any point during the study duration.\n\niii. Smoker \u002Falcoholic iv. Has platelet dysfunction\u002F thrombocytopenia\u002F blood dyscrasia v. On bisphosphonates or drugs that will significantly alter bone metabolism. vi. ASA III\u002FIV.",true,"ALL","18 Years",{"count":60,"type":61},74,"ESTIMATED","INTERVENTIONAL",[64],"NA","This study aim to investigate the effect of albumin gel- and platelet- rich fibrin(Alb-PRF) combined with advanced platelet-rich fibrin (A-PRF) on alveolar ridge preservation by comparing alveolar ridge morphometric changes (hard and soft tissue), prospects and treatment complexity for placement of prosthetically guided dental implant, early oral wound healing outcomes evaluated by the Inflammatory Proliferative Remodeling Scale, and patient reported outcome measures, in Type I\u002FII Diabetes Mellitus patient, versus spontaneous healing",[67],"Tooth Extraction Status Nos","NOT_YET_RECRUITING","2023-11-24",{"date":71,"type":72},"2023-11-29","ACTUAL",{"date":74,"type":61},"2024-09-01",{"date":76,"type":61},"2026-06-30",{"name":5,"class":6}]