[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100523058":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":30,"responsibleParty":49,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":10,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Tianjin Huanhu Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Cognitive Impairment (CI) group and No Cognitive Impairment (NCI) group",null,"We intend to recruit 200 patients with primary PD to undergo DBS surgery or only TMS treatment according to whether the surgical indication is available. We will observe the changes in cognitive function of patients before and after different brain stimulation treatments.\n\nParkinson's disease patients with cognitive impairment after brain stimulation were divided into cognitive impairment group, and those without cognitive impairment after treatment were divided into no cognitive impairment group",[13],"Device: Deep Brain Stimulation(DBS) and Transcranial Magnetic Stimulation(TMS)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DEVICE","Deep Brain Stimulation(DBS) and Transcranial Magnetic Stimulation(TMS)","We observed the changes in cognitive function of patients before and after different brain stimulation treatments, and further compared the effects of different brain stimulation treatments on cognitive function of PD patients and the related mechanisms according to whether DBS surgery was performed or TMS therapy was given only according to the surgical indications.",[9],[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Zhao Guangrui, doctor","CONTACT","+86 18956405513","Guangrui-Zhao@hotmail.com",{"name":27,"role":23,"phone":28,"phoneExt":10,"email":29},"Feng Keke, doctor","+86 18920195507","fengke1976@163.com",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Tianjin","Tianjin Municipality","300070","China","CN",{"type":39,"coordinates":40},"Point",[41,42],117.17667,39.14222,{"lat":42,"lon":41},[45],{"name":46,"role":23,"phone":47,"phoneExt":10,"email":48},"Yin Shaoya, doctor","+86 18622139285","yinsya@hotmail.com",{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Guangrui Zhao","Associate Professor","100523058","effect-and-mechanism-of-brain-stimulation-for-parkinsons-disease-with-cognitive-impairment-100523058",false,"NCT06090682","Effect and Mechanism of Brain Stimulation for Parkinson's Disease With Cognitive Impairment","Effect and Mechanism of Deep Brain Stimulation and Transcranial Magnetic Stimulation on Parkinson's Disease With Cognitive Impairment","Inclusion Criteria:\n\n1\\. The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, acute levodopa motor response ≥30%, and indication for STN-DBS.\n\nExclusion Criteria:\n\nExclusion criteria included patients with severe cognitive impairment, severe psychiatric disorders, acute levodopa motor response less than 30%, atypical parkinsonism, and contraindications to surgery.","ALL","75 Years",{"count":63,"type":64},200,"ESTIMATED","OBSERVATIONAL","This study intends to apply structural and functional brain network neuroimaging techniques combined with image post-processing methods to explore the differences in brain network changes in PD patients with cognitive impairment after DBS or TMS.",[68,69],"Parkinson Disease","Cognitive Impairment",[68,69,71,72],"Deep brain stimulation","Transcranial magnetic stimulation","2023-10-14",{"date":75,"type":76},"2023-10-19","ACTUAL",{"date":78,"type":64},"2023-11-01",{"date":80,"type":64},"2027-11-01",{"name":5,"class":6},1]