[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624341":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":33,"centralContacts":34,"locations":40,"responsibleParty":161,"collaborators":33,"id":163,"slug":164,"hasResults":165,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":165,"sex":171,"minAge":172,"maxAge":33,"enrollmentInfo":173,"targetDuration":33,"studyType":176,"phases":177,"briefSummary":179,"conditions":180,"keywords":182,"overallStatus":80,"whyStopped":33,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":197},{"fullName":5,"class":6},"Nantes University Hospital","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Driving pressure with a fixed setting of 1.4 bars","ACTIVE_COMPARATOR","On the day of the interventional radiology surgery (Day 0), the driving pressure setting will be of 1.4 bars.",[13],"Procedure: High-Frequency Jet Ventilation (HFJV)",{"label":15,"type":10,"description":16,"interventionNames":17},"Driving pressure with a fixed setting of 1.9 bars","On the day of the interventional radiology surgery (Day 0), the driving pressure setting will be of 1.9 bars.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Driving pressure with a fixed setting of 2.4 bars","On the day of the interventional radiology surgery (Day 0), the driving pressure setting will be of 2.4 bars.",[13],{"label":23,"type":24,"description":25,"interventionNames":26},"Driving pressure with a personalized setting","EXPERIMENTAL","On the day of the interventional radiology surgery (Day 0), the driving pressure setting will be personalized according to the patient's height : 1.4 bars if patient's height \\\u003C 150 cm, 1.6 bars if patient's height is between 150 cm and 160 cm, 1.8 bars if patient's height is between 161 cm and 170 cm, 2.0 bars if patient's height is between 171 cm and 180 cm, 2.2 bars if patient's height is between 181 cm and 190 cm and 2.4 bars if patient's height \\> 190 cm",[13],[28],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"PROCEDURE","High-Frequency Jet Ventilation (HFJV)","High-Frequency Jet Ventilation (HFJV) involves ventilating with a small tidal volume of gas at a high frequency, ensuring diaphragmatic stability. This stability allows for the precise superimposition of localization and puncture images.\n\nHFJV is defined as a ventilation mode with very high insufflation rates (120 to 200 cycles per minute) delivering a low tidal volume through a catheter with a gauge of 13G to 16G.",[9,15,19,23],null,[35],{"name":36,"role":37,"phone":38,"phoneExt":33,"email":39},"Nathalie DESFRICHES-DORIA","CONTACT","0244768434","nathalie.desfrichesdoria@chu-nantes.fr",[41,64,78,93,110,127,144],{"facility":42,"status":43,"city":44,"state":33,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"CHU de Lyon","NOT_YET_RECRUITING","Lyon","69002","France","FR",{"type":49,"coordinates":50},"Point",[51,52],4.84789,45.74906,{"lat":52,"lon":51},[55,59,61],{"name":56,"role":37,"phone":57,"phoneExt":33,"email":58},"Stéphanie CLERC","0472118088","stephanie.clerc@chu-lyon.fr",{"name":56,"role":60,"phone":33,"phoneExt":33,"email":33},"PRINCIPAL_INVESTIGATOR",{"name":62,"role":63,"phone":33,"phoneExt":33,"email":33},"Emma AKA","SUB_INVESTIGATOR",{"facility":65,"status":43,"city":44,"state":33,"zip":66,"country":46,"countryCode":47,"cosmosGeoPoint":67,"geoPoint":69,"contacts":70},"Centre Léon Bérard","69008",{"type":49,"coordinates":68},[51,52],{"lat":52,"lon":51},[71,75,76],{"name":72,"role":37,"phone":73,"phoneExt":33,"email":74},"Alexandre MEYER","0478782828","alexandre.meyer@lyon.unicancer.fr",{"name":72,"role":60,"phone":33,"phoneExt":33,"email":33},{"name":77,"role":63,"phone":33,"phoneExt":33,"email":33},"Gaëlle BOUROCHE",{"facility":79,"status":80,"city":81,"state":33,"zip":82,"country":46,"countryCode":47,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"CHU de Nantes","RECRUITING","Nantes","44093",{"type":49,"coordinates":84},[85,86],-1.55336,47.21725,{"lat":86,"lon":85},[89,90,91],{"name":36,"role":37,"phone":38,"phoneExt":33,"email":39},{"name":36,"role":60,"phone":33,"phoneExt":33,"email":33},{"name":92,"role":63,"phone":33,"phoneExt":33,"email":33},"Nicolas GRILLOT",{"facility":94,"status":43,"city":95,"state":33,"zip":96,"country":46,"countryCode":47,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"CHU de Nîmes","Nîmes","30900",{"type":49,"coordinates":98},[99,100],4.35788,43.83665,{"lat":100,"lon":99},[103,107,108],{"name":104,"role":37,"phone":105,"phoneExt":33,"email":106},"Natacha SIMON-MONNIER","0466686868","natacha.simon@chu-nimes.fr",{"name":104,"role":60,"phone":33,"phoneExt":33,"email":33},{"name":109,"role":63,"phone":33,"phoneExt":33,"email":33},"Danielle GARNIER",{"facility":111,"status":43,"city":112,"state":33,"zip":113,"country":46,"countryCode":47,"cosmosGeoPoint":114,"geoPoint":118,"contacts":119},"CHU de Poitiers","Poitiers","86000",{"type":49,"coordinates":115},[116,117],0.34348,46.58261,{"lat":117,"lon":116},[120,124,125],{"name":121,"role":37,"phone":122,"phoneExt":33,"email":123},"Anne MERCIER","0615052500","anne.mercier@chu-poitiers.fr",{"name":121,"role":60,"phone":33,"phoneExt":33,"email":33},{"name":126,"role":63,"phone":33,"phoneExt":33,"email":33},"Denis FRASCA",{"facility":128,"status":43,"city":129,"state":33,"zip":130,"country":46,"countryCode":47,"cosmosGeoPoint":131,"geoPoint":135,"contacts":136},"ICO Unicancer","Saint-Herblain","44800",{"type":49,"coordinates":132},[133,134],-1.651,47.21154,{"lat":134,"lon":133},[137,141,142],{"name":138,"role":37,"phone":139,"phoneExt":33,"email":140},"Roland MARTIN","0240679900","roland.martin@ico-unicancer.fr",{"name":138,"role":60,"phone":33,"phoneExt":33,"email":33},{"name":143,"role":63,"phone":33,"phoneExt":33,"email":33},"Vincent LE NESTOUR",{"facility":145,"status":80,"city":146,"state":33,"zip":147,"country":46,"countryCode":47,"cosmosGeoPoint":148,"geoPoint":152,"contacts":153},"Institut Gustave Roussy","Villejuif","94800",{"type":49,"coordinates":149},[150,151],2.35992,48.7939,{"lat":151,"lon":150},[154,158,159],{"name":155,"role":37,"phone":156,"phoneExt":33,"email":157},"Sandrine GARDE","0142116724","sandrine.garde@gustaveroussy.fr",{"name":155,"role":60,"phone":33,"phoneExt":33,"email":33},{"name":160,"role":63,"phone":33,"phoneExt":33,"email":33},"Emma EVRARD",{"type":162,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100624341","effect-of-a-driving-pressure-adjustment-procedure-for-high-frequency-jet-ventilation-in-patients-undergoing-tumor-thermal-ablation-in-interventional-radiology-100624341",false,"NCT07408375","Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology","Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology - A Randomized, Controlled, Multicenter Study","Pulmojet 3","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Patient undergoing thermal ablation of a solid tumor under HFJV.\n* Patient who has given their consent.\n* Patient covered by a social security scheme.\n\nExclusion Criteria:\n\n* Patient under guardianship or curatorship.\n* Patient who does not understand French.\n* Pregnant and breastfeeding woman\n* Patient who has had a pneumonectomy\n* Patient requiring an endotracheal tube smaller than 6.5","ALL","18 Years",{"count":174,"type":175},560,"ESTIMATED","INTERVENTIONAL",[178],"NA","Tumor thermal ablation under Jet Ventilation is a procedure performed under general anesthesia that enables tumor ablation under radiological imaging guidance.\n\nThis procedure, being less invasive than conventional surgery, allows for a faster recovery and hospital discharge. This procedure requires significant precision to ensure the most complete destruction of the tumor, while also preserving adjacent organs. During general anesthesia, respiratory movements complicate radiological localization and tumor destruction.\n\nThe principle of High-Frequency Jet Ventilation (HFJV) involves using a device that ventilates a small volume of air and oxygen at a specific pressure, called driving pressure, at a high frequency.\n\nThis ventilation mode reduces respiratory movements while ensuring continuous ventilation and oxygenation. This respiratory stability allows for the precision necessary to superimpose images for tumor localization and destruction.\n\nThere are no guidelines regarding the driving pressure setting for HFJV for tumor thermal ablation. The method tested in this research is based on patient's height to optimize the driving pressure when using HFV.\n\nThe main objective of this research is to evaluate the impact of driving pressure settings, on respiratory function, taking into account patient's height.\n\nOn the day of the procedure, the driving pressure setting for the HFJV will be randomly assigned (1.4 bars, 1.9 bars, 2.4 bars, or customized according to the patient's height) (1 bar = 14 psi).\n\nThe research will be conducted using medical data collected during routine patient care. Patient participation will last for the duration of their hospital stay, approximately two days.",[181],"Solid Tumor (Excluding CNS)",[183,184,185,186,187],"Ventilation","High-Frequency Jet Ventilation","Anesthesia","Interventional Radiology","Tumor ablation","2026-03-26",{"date":190,"type":191},"2026-03-27","ACTUAL",{"date":193,"type":191},"2026-03-13",{"date":195,"type":175},"2028-03-13",{"name":5,"class":6},7]