[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100500011":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":39,"responsibleParty":134,"collaborators":26,"id":136,"slug":137,"hasResults":138,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":26,"eligibilityCriteria":142,"healthyVolunteers":138,"sex":143,"minAge":144,"maxAge":145,"enrollmentInfo":146,"targetDuration":26,"studyType":149,"phases":150,"briefSummary":152,"conditions":153,"keywords":26,"overallStatus":42,"whyStopped":26,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":165},{"fullName":5,"class":6},"Poitiers University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Atrial fibrillation + antiarrhythmic drugs","EXPERIMENTAL","The ablation can be done with different sources of energy (radiofrequency, cryoballoon or pulsed field ablation). Different sets of lesions can be performed but the cornerstone is pulmonary vein isolation which will be mandatory.\n\nAntiarrhythmic drugs management will be at the operator discretion. Some operators may stop antiarrhythmic drugs after atrial fibrillation ablation.",[13],"Procedure: Atrial fibrillation ablation + antiarrhythmic drugs",{"label":15,"type":16,"description":17,"interventionNames":18},"Antiarrhythmic drugs alone","ACTIVE_COMPARATOR","Antiarrhythmic drugs available available are amiodarone, flecainide, propafenone, sotalol.\n\nIf not previously started, patients randomized to antiarrhythmic drugs arm should start antiarrhythmic drugs therapy within 1 week of randomization.\n\nApart from these recommendations, antiarrhythmic drugs management will be at the operator discretion.",[19],"Drug: Antiarrhythmic drug",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Atrial fibrillation ablation + antiarrhythmic drugs","Atrial fibrillation ablation will be performed with endovascular catheters and will be done either with radiofrequency, cryoballoon or pulsed field ablation.\n\nAmiodarone, flecainide, sotalol, propafenone are the anti arrhythmic drugs allowed.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DRUG","Antiarrhythmic drug","Amiodarone, flecainide, sotalol, propafenone are the anti arrhythmic drugs allowed.",[15],[33],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Rodrigue Garcia","CONTACT","549443729","+33","rodrigue.garcia@chu-poitiers.fr",[40,57,68,78,88,100,113,122],{"facility":41,"status":42,"city":43,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"CHU Angers","RECRUITING","Angers","France","FR",{"type":47,"coordinates":48},"Point",[49,50],-0.55202,47.47156,{"lat":50,"lon":49},[53],{"name":54,"role":35,"phone":55,"phoneExt":26,"email":56},"Sophie Le Page","+332 41 35 36 37","sophie.lepage@chu-angers.fr",{"facility":58,"status":42,"city":59,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"University Hospital","Brest",{"type":47,"coordinates":61},[62,63],-4.48628,48.39029,{"lat":63,"lon":62},[66],{"name":67,"role":35,"phone":26,"phoneExt":26,"email":26},"Jacques Mansourati",{"facility":58,"status":42,"city":69,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Caen",{"type":47,"coordinates":71},[72,73],-0.35912,49.18585,{"lat":73,"lon":72},[76],{"name":77,"role":35,"phone":26,"phoneExt":26,"email":26},"Pierre Ollitrault",{"facility":58,"status":42,"city":79,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Dijon",{"type":47,"coordinates":81},[82,83],5.01391,47.31344,{"lat":83,"lon":82},[86],{"name":87,"role":35,"phone":26,"phoneExt":26,"email":26},"Charles Guenancia",{"facility":89,"status":42,"city":90,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"CHU Grenoble","Grenoble",{"type":47,"coordinates":92},[93,94],5.71479,45.17869,{"lat":94,"lon":93},[97],{"name":98,"role":35,"phone":99,"phoneExt":26,"email":26},"Peggy Jacon","+334 76 76 75 75",{"facility":101,"status":42,"city":102,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"La Timone","Marseille",{"type":47,"coordinates":104},[105,106],5.38107,43.29695,{"lat":106,"lon":105},[109],{"name":110,"role":35,"phone":111,"phoneExt":26,"email":112},"Baptiste Maille","+33491 38 00 00","baptiste.maille@aphm.fr",{"facility":58,"status":42,"city":114,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"Poitiers",{"type":47,"coordinates":116},[117,118],0.34348,46.58261,{"lat":118,"lon":117},[121],{"name":34,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":123,"status":124,"city":125,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":126,"geoPoint":130,"contacts":131},"Centre Cardiologique du Nord","NOT_YET_RECRUITING","Saint-Denis",{"type":47,"coordinates":127},[128,129],2.35387,48.93564,{"lat":129,"lon":128},[132],{"name":133,"role":35,"phone":26,"phoneExt":26,"email":26},"Olivier Piot",{"type":135,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100500011","effect-of-ablation-of-persistent-atrial-fibrillation-on-cognitive-function-in-individuals-with-mild-cognitive-impairment-100500011",false,"NCT05790707","EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment","EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment : - The FALCON Study-","Inclusion Criteria:\n\n* Patients aged 60 to 80 years\n* Persistent atrial fibrillation\n* Patients with an indication for cardiac rhythm control.\n* Montreal Cognitive Assessment score between 18 and 25 points corresponding to mild cognitive impairment\n* Free subject, not under temporary or permanent guardianship and not subject to subordination\n* Subject understanding and accepting the constraints of the study\n* Patient covered by French national health insurance or benefiting from it through a third party\n* Subject has given written consent to the study after having received clear and complete information\n\nExclusion Criteria:\n\n* Impossibility to perform the neuropsychological evaluation (communication problems such as hearing loss or aphasia, language barrier)\n* History of clinical stroke\n* Presence of a bruit at carotid auscultation or history of severe carotid stenosis\n* History or suspicion of neurodegenerative disease (Parkinson's disease, Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis...), bipolar disorder, schizophrenia, severe depression or amyloidosis\n* Patient with history of previous atrial fibrillation ablation\n* Patient undergoing flutter ablation or atrial tachycardia ablation (not atrial fibrillation ablation)\n* Contraindication to atrial fibrillation ablation (intracardiac thrombus, severe pulmonary hypertension, mechanical mitral valve prosthesis or contraindication to anticoagulation,…)\n* Contraindication to antiarrhythmic drugs, or to implantable cardiac monitor\n* Patient with very advanced persistent atrial fibrillation, i.e., for more than 3 years or with a left atrial diameter \\>60 mm in parasternal long axis section or a left atrial volume \\> 48ml\u002Fm2 in echocardiography\n* Subject with a life expectancy of less than 24 months at study enrolment\n* Inability to consent\n* Persons benefiting from a reinforced protection, namely minors, persons deprived of liberty by a judicial or administrative decision, adults under legal protection, and finally patients in emergency situations\n* Pregnant or breastfeeding women, women at age to procreate and not using effective contraception (hormonal\u002Fbarrier: oral, parenteral, percutaneous implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total ovariectomy)","ALL","60 Years","80 Years",{"count":147,"type":148},120,"ESTIMATED","INTERVENTIONAL",[151],"NA","The goal of this clinical trial is to evaluate the effect of catheter ablation of persistent atrial fibrillation on cognitive function in patients with mild cognitive impairment. Participants will be randomized into antiarrhythmic drugs alone or atrial fibrillation ablation + antiarrhythmic drugs.",[154,155],"Mild Cognitive Impairment","Persistent Atrial Fibrillation","2026-01-21",{"date":158,"type":159},"2026-01-23","ACTUAL",{"date":161,"type":159},"2023-04-21",{"date":163,"type":148},"2027-07",{"name":5,"class":6},8]