[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100403438":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":39,"centralContacts":43,"locations":49,"responsibleParty":67,"collaborators":31,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":31,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":31,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":31,"overallStatus":52,"whyStopped":31,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Huazhong University of Science and Technology","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Acupuncture group","EXPERIMENTAL","Acupuncture + IVF.",[13],"Device: acupuncture and IVF",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham acupuncture group","SHAM_COMPARATOR","Sham acupuncture +IVF. We formulate and follow standardised step-by-step instructions and operations to use the same rituals in the acupuncture and sham acupuncture groups as far as possible.",[19],"Device: sham acupuncture and IVF",{"label":21,"type":6,"description":22,"interventionNames":23},"control group","only IVF",[24],"Other: control group",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","acupuncture and IVF","Acupuncture was performed three times a week for 30 minutes each time, starting from the 5th day of menstruation before the cycle of the transfer and ending within 24 hours after embryo transfer.",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"sham acupuncture and IVF","Sham acupuncture was performed three times a week for 30 minutes each time, starting from the 5th day of menstruation before the cycle of the transfer and ending within 24 hours after embryo transfer.",[15],{"type":6,"name":21,"description":37,"armGroupLabels":38,"otherNames":31},"no acupuncture, only IVF",[21],[40],{"name":41,"affiliation":5,"role":42},"Minming Zhang, professor","PRINCIPAL_INVESTIGATOR",[44],{"name":45,"role":46,"phone":47,"phoneExt":31,"email":48},"Cuihong Zheng, professor","CONTACT","86-27-83663275","chzheng@tjh.tjmu.edu.cn",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Tongji Hospital,Tongji medical college,HUST","RECRUITING","Wuhan","Hubei","430030","China","CN",{"type":59,"coordinates":60},"Point",[61,62],114.26667,30.58333,{"lat":62,"lon":61},[65,66],{"name":45,"role":46,"phone":31,"phoneExt":31,"email":31},{"name":41,"role":42,"phone":31,"phoneExt":31,"email":31},{"type":42,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Cui Hong Zheng","associate professor","100403438","effect-of-acupuncture-on-ivf-pregnancy-outcomes-for-women-with-rif-100403438",false,"NCT04533295","Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF","Effect of Acupuncture on IVF Pregnancy Outcomes for Women With Recurrent Implantation Failure: a Multi-center Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Married women aged 25-40;\n2. Repeated implantation failure for unknown reasons (experienced 2 or more embryo transfers of good-quality embryos without achieving clinical pregnancy);\n3. Transplantable Day 3 high-quality frozen embryos or frozen blastocysts (≥3BB);\n4. Estrogen and progesterone replacement therapy (HRT), endometrial thickness ≥7mm on the day of endometrial transformation.\n\nExclusion Criteria:\n\nPatients who met any of the following conditions were not included.\n\n1. Those who prepare for PGD;\n2. Recipients of egg donors;\n3. Chromosomal abnormalities in both or one of the couples (excluding chromosome polymorphism);\n4. patients with implantation failure due to known embryonic factors;\n5. Uterine lesions that may affect implantation (including uterine malformation, \\>4cm intramural fibroids，submucosal fibroids, adenomyosis, uterine tuberculosis, intrauterine adhesions, etc.\n6. Repeated spontaneous abortion (2 or more fetal loss before 28 weeks of gestation);\n7. Patients with other endocrine diseases, such as thyroid disease, hyperprolactinemia, insulin resistance, diabetes, adrenal disease, etc., and poor control of hormone levels in the last 3 months;\n8. Clearly diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, etc.;\n9. Hydrosalpinx untreated;\n10. BMI less than 18 or higher than 25kg\u002Fm2;\n11. People with previous history of needle sickness;\n12. Those who have previously participated in this study or received acupuncture treatment in the past 3 months.\n13. Any situation that researchers consider inappropriate for participating in this study.","FEMALE","25 Years","40 Years",{"count":81,"type":82},771,"ESTIMATED","INTERVENTIONAL",[85],"NA","The randomized, placebo-controlled multicenter trial is conducted in five centers in China. After screening and obtaining the signed informed consent , the participants are randomly divided into three groups: acupuncture group (Acu.+IVF），sham acupuncture group（Sham Acu. +IVF），and the control group (only IVF).",[88],"Repeated Implantation Failure","2026-03-08",{"date":91,"type":92},"2026-03-10","ACTUAL",{"date":94,"type":92},"2020-11-02",{"date":96,"type":82},"2027-09-01",{"name":5,"class":6},1]