[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629994":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":138,"collaborators":26,"id":141,"slug":142,"hasResults":143,"nctId":144,"briefTitle":145,"officialTitle":145,"acronym":26,"eligibilityCriteria":146,"healthyVolunteers":143,"sex":147,"minAge":148,"maxAge":149,"enrollmentInfo":150,"targetDuration":26,"studyType":153,"phases":154,"briefSummary":156,"conditions":157,"keywords":165,"overallStatus":169,"whyStopped":26,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":179},{"fullName":5,"class":6},"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"EA group","EXPERIMENTAL","Participants undergo 16 sessions of electroacupuncture twice weekly over 8 weeks.",[13],"Device: electroacupuncture",{"label":15,"type":16,"description":17,"interventionNames":18},"SA group","SHAM_COMPARATOR","Participants undergo 16 sessions of sham electroacupuncture(noninsertive simulated acupuncture and sham electrical stimulation) twice weekly over 8 weeks.",[19],"Device: sham electroacupuncture",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","electroacupuncture","A semi-standardized protocol is used for participants in the EA group, which includes (1) standardized acupoints (Midline: Baihui \\[GV20\\], Shenting \\[GV24\\], Qihai \\[CV6\\], Guanyuan \\[CV4\\]; Bilateral: Fengchi \\[GB20\\], Taiyang \\[EX-HN5\\], Zusanli \\[ST36\\], Hegu \\[LI4\\], Taichong \\[LR3\\]); and (2) additional acupoints (Sishencong \\[EX-HN1\\] and bilateral Benshen \\[GB13\\] for anxiety\u002Fdepression\u002Fsubjective cognitive decline; 1-2 Ashi points for pain; no additional points for insomnia\u002Ffatigue). Meanwhile, electrical stimulation is conducted on three pairs of acupoints with electrode cord connection as follows: Baihui \\[GV20\\] and Shenting \\[GV24\\], left Fengchi \\[GB20\\] and left Taiyang \\[EX-HN5\\], right Fengchi \\[GB20\\] and right Taiyang \\[EX-HN5\\]. Electrical stimulation is delivered in continuous wave mode at 2 Hz with current intensity adjusted according to participant's tolerance. Electrical stimulation last 30 min. The needles on body acupoints are also retain for 30 min.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"sham electroacupuncture","In the SA group, noninsertive simulated acupuncture and sham electrical stimulation(30-second transient device activation instead of 30-minute continuous stimulation) are used, while maintaining the same treatment duration and course as the EA group. Blunt needles are placed on 12 acupoints (Bilateral: Fengchi \\[GB20\\], Taiyang \\[EX-HN5\\], Zusanli \\[ST36\\], Hegu \\[LI4\\], Taichong \\[LR3\\]; Midline: Qihai \\[CV6\\], Guanyuan \\[CV4\\]) without skin penetration. Electrical stimulation is conducted on two pairs of acupoints with electrode cord connection as follows: left Fengchi \\[GB20\\] and left Taiyang \\[EX-HN5\\], right Fengchi \\[GB20\\] and right Taiyang \\[EX-HN5\\]. A 2 Hz continuous wave is delivered for 30 seconds, after which the EA device is immediately turned off. The blunt needles are maintained in position for 30 minutes to match the retention time in the EA group.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Shiyan Yan","CONTACT","+86 22 27986078","yanshiyan0927@sina.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Ruihan Guo","+86 135 2033 6216","grh1882025@163.com",[42,63,76,93,110,126],{"facility":43,"status":26,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Senior Department of Oncology，Chinese PLA General Hospital","Beijing","Beijing Municipality","100039","China","CN",{"type":50,"coordinates":51},"Point",[52,53],116.39723,39.9075,{"lat":53,"lon":52},[56,60],{"name":57,"role":34,"phone":58,"phoneExt":26,"email":59},"Hua Song, PhD","+86 10-66947798","dzliyujun@163.com",{"name":61,"role":62,"phone":26,"phoneExt":26,"email":26},"Shaohua Zhang, PhD","PRINCIPAL_INVESTIGATOR",{"facility":64,"status":26,"city":44,"state":45,"zip":65,"country":47,"countryCode":48,"cosmosGeoPoint":66,"geoPoint":68,"contacts":69},"Xiyuan Hospital of CACMS","100091",{"type":50,"coordinates":67},[52,53],{"lat":53,"lon":52},[70,74],{"name":71,"role":34,"phone":72,"phoneExt":26,"email":73},"JuLing Jiang","+86 10 62835438","1192296624@qq.com",{"name":75,"role":62,"phone":26,"phoneExt":26,"email":26},"ZhongNing Guo, PhD",{"facility":77,"status":26,"city":78,"state":79,"zip":80,"country":47,"countryCode":48,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)","Nanjing","Jiangsu","210029",{"type":50,"coordinates":82},[83,84],118.77778,32.06167,{"lat":84,"lon":83},[87,91],{"name":88,"role":34,"phone":89,"phoneExt":26,"email":90},"Jing Lu","+86 25 68306522","lujing0728@163.com",{"name":92,"role":62,"phone":26,"phoneExt":26,"email":26},"Jing Lu, PhD",{"facility":94,"status":26,"city":95,"state":96,"zip":97,"country":47,"countryCode":48,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Qingdao Traditional Chinese Medicine Hospital, Qingdao Hiser Hospital Affiliated of Qingdao University","Qingdao","Shandong","266000",{"type":50,"coordinates":99},[100,101],120.38042,36.06488,{"lat":101,"lon":100},[104,108],{"name":105,"role":34,"phone":106,"phoneExt":26,"email":107},"YiBo He","+86 532 83777906","heyibozyy@126.com",{"name":109,"role":62,"phone":26,"phoneExt":26,"email":26},"Bo Liu, PhD",{"facility":111,"status":26,"city":112,"state":113,"zip":114,"country":47,"countryCode":48,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"Tianjin Medical University Cancer Institute & Hospital (TMUCIH)","Tianjin","Tianjin Municipality","300060",{"type":50,"coordinates":116},[117,118],117.17667,39.14222,{"lat":118,"lon":117},[121,125],{"name":122,"role":34,"phone":123,"phoneExt":26,"email":124},"Bin Wang, PhD","+86 22 23340123-6417","wbin8888@163.com",{"name":122,"role":62,"phone":26,"phoneExt":26,"email":26},{"facility":5,"status":26,"city":112,"state":113,"zip":127,"country":47,"countryCode":48,"cosmosGeoPoint":128,"geoPoint":130,"contacts":131},"300381",{"type":50,"coordinates":129},[117,118],{"lat":118,"lon":117},[132,136],{"name":133,"role":34,"phone":134,"phoneExt":26,"email":135},"ZiYu Kuang, PhD","+86 22 27986525","kzy1303088356@163.com",{"name":137,"role":62,"phone":26,"phoneExt":26,"email":26},"FanMing Kong, PhD",{"type":62,"investigatorFullName":139,"investigatorTitle":140,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Yan Shiyan","Principal Investigator","100629994","effect-of-acupuncture-on-psychoneurological-symptom-cluster-in-breast-cancer-survivors-100629994",false,"NCT07481903","Effect of Acupuncture on Psychoneurological Symptom Cluster in Breast Cancer Survivors","Inclusion Criteria：\n\n1. Female, aged 18-75 years;\n2. Histologically confirmed Stage 0, I, II, or III breast cancer (according to the AJCC 8th edition)；\n3. Completed active treatment (surgery, chemotherapy, and\u002For radiotherapy) at least 1 month prior to study initiation , and are currently receiving endocrine therapy；\n4. Meet at least 2 of the following 6 criteria:\n\n(1)Visual Analogue Scale (VAS) score for pain ≥ 4 (2)Pittsburgh Sleep Quality Index (PSQI) score ≥ 8 (3)Brief Fatigue Inventory-Chinese version (BFI-C) score ≥ 4 (4)Hospital Anxiety and Depression Scale-Anxiety subscale (HADS-A) score ≥ 8 (5)Hospital Anxiety and Depression Scale-Depression subscale (HADS-D) score ≥ 8 (6)Functional Assessment of Cancer Therapy-Cognitive Function-Perceived Cognitive Impairments (FACT-Cog-PCI) score \\\u003C 60 ; 5.Has signed the informed consent form and voluntarily participates in this study.\n\nExclusion Criteria:\n\n1. History of psychiatric disorders (e.g., bipolar disorder, schizophrenia, substance addiction)\n2. Presence of diseases that may impair cognitive function or interfere with study assessments (e.g., Alzheimer's disease, Parkinson's disease, brain tumors).\n3. Fatigue attributable to a treatable condition (e.g., hypothyroidism).\n4. Severe debilitation or significant organic disease (e.g., heart failure, severe hepatic\u002Frenal insufficiency, severe anemia, uncontrolled infection).\n5. Use of anxiolytics, antidepressants, psychostimulants, or sedative-hypnotics within the past 4 weeks.\n6. Chronic use of corticosteroids.\n7. Prior acupuncture treatment within 3 months, or participation in an acupuncture or drug clinical trial within 6 months.\n8. History of hemorrhagic disease, severe coagulation dysfunction, or current use of anticoagulants (e.g., warfarin).\n9. Implanted cardiac pacemaker.\n10. Pregnancy or breastfeeding.\n11. Concurrent participation in another clinical study.","FEMALE","18 Years","75 Years",{"count":151,"type":152},228,"ESTIMATED","INTERVENTIONAL",[155],"NA","This clinical trial aims to assess whether electroacupuncture (EA) can alleviate the psychoneurological symptom cluster (including pain, fatigue, insomnia, anxiety, depression and subjective cognitive decline) in breast cancer survivors, and to evaluate the safety of this therapy.\n\nResearchers will conduct a randomized controlled trial of electroacupuncture (EA) as compared to sham electroacupuncture (SA) in breast cancer survivors with the psychoneurological symptom cluster who are currently being treated with endocrine therapy.\n\nParticipants will receive 16 treatments over 8 weeks. The EA group will receive true acupuncture with continuous wave stimulation (2Hz, intensity as tolerated) administered for 30 minutes per session. The SA group will receive sham acupuncture using blunt (non-penetrating) needles that contact the skin without penetration, along with a 30-second transient device activation instead of the 30-minute continuous stimulation.\n\nTreatment outcomes for pain, fatigue, insomnia, anxiety, depression and subjective cognitive function will be assessed. The primary outcome is response rate of the psychoneurological symptom cluster after 8 weeks of treatment. Secondary outcomes include changes from baseline in the scores of each of the six psychoneurological symptoms.",[158,159,160,161,162,163,164],"Psychoneurological Symptom Cluster(Pain, Insomnia, Anxiety, Fatigue, Depression, Subjective Cognitive Decline)","Pain","Insomnia","Anxiety","Fatigue","Depression","Subjective Cognitive Decline (SCD)",[166,167,168],"Psychoneurological Symptom Cluster","Breast Cancer","Acupuncture","NOT_YET_RECRUITING","2026-03-15",{"date":172,"type":173},"2026-03-19","ACTUAL",{"date":175,"type":152},"2026-04",{"date":177,"type":152},"2028-07",{"name":5,"class":6},6]