[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626126":3},{"organization":4,"armGroups":7,"interventions":33,"overallOfficials":42,"centralContacts":46,"locations":57,"responsibleParty":80,"collaborators":51,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":85,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":51,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":105,"overallStatus":60,"whyStopped":51,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"University of Zurich","OTHER",[8,13,17,21,25,29],{"label":9,"type":6,"description":10,"interventionNames":11},"Arm ABC (normobaric normoxia - normobaric hypoxia 2500m - normobaric hypoxia 4000m)","The participant receives first normobaric normoxia (A), then normobaric hypoxia equal to 2500 m.a.s.l. (B) then normobaric hypoxia representing 4000 m.a.s.l. (C). Condition A represents the control.",[12],"Other: Normobaric Hypoxia",{"label":14,"type":6,"description":15,"interventionNames":16},"Arm ACB (normobaric normoxia - normobaric hypoxia 4000m - normobaric hypoxia 2500m)","The participant receives first normobaric normoxia (A), then normobaric hypoxia representing 4000 m.a.s.l. (C), then normobaric hypoxia equal to 2500 m.a.s.l. (B). Condition A represents the control.",[12],{"label":18,"type":6,"description":19,"interventionNames":20},"Arm BAC (normobaric hypoxia 2500m - normobaric normoxia - normobaric hypoxia 4000m)","The participant receives first normobaric hypoxia equal to 2500 m.a.s.l. (B), then normobaric normoxia (A), then normobaric hypoxia representing 4000 m.a.s.l. (C). Condition A represents the control.",[12],{"label":22,"type":6,"description":23,"interventionNames":24},"Arm BCA (normobaric hypoxia 2500m - normobaric hypoxia 4000m - normobaric normoxia)","The participant receives first normobaric hypoxia equal to 2500 m.a.s.l. (B), then normobaric hypoxia representing 4000 m.a.s.l. (C), then normobaric normoxia (A). Condition A represents the control.",[12],{"label":26,"type":6,"description":27,"interventionNames":28},"Arm CAB (normobaric hypoxia 4000m - normobaric normoxia - normobaric hypoxia 2500m)","The participant receives first normobaric hypoxia representing 4000 m.a.s.l. (C), then normobaric normoxia (A), then normobaric hypoxia equal to 2500 m.a.s.l. (B). Condition A represents the control.",[12],{"label":30,"type":6,"description":31,"interventionNames":32},"Arm CBA (normobaric hypoxia 4000m - normobaric hypoxia 2500m - normobaric normoxia)","The participant receives first normobaric hypoxia representing 4000 m.a.s.l. (C), then normobaric hypoxia equal to 2500 m.a.s.l. (B), then normobaric normoxia (A). Condition A represents the control.",[12],[34],{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"Normobaric Hypoxia","Normobaric hypoxia according to 408m (control\u002Fnormobaric normoxia), 2500 m and 4000 m above sea-level at rest for 1 hour and at low intensity cycling for 10 minutes (5 min 30 W, 5 min 60 W).",[9,14,18,22,26,30],[39,40,41],"rest","low intensity cycling","normobaric normoxia",[43],{"name":44,"affiliation":5,"role":45},"Mona Lichtblau","PRINCIPAL_INVESTIGATOR",[47,53],{"name":48,"role":49,"phone":50,"phoneExt":51,"email":52},"Mona Lichtblau, PD Dr. med.","CONTACT","+41 442552220",null,"mona.lichtblau@usz.ch",{"name":54,"role":49,"phone":55,"phoneExt":51,"email":56},"Carmen Wick, Cand. PhD","+41 43 253 44 05","carmen.wick@usz.ch",[58],{"facility":59,"status":60,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"Consultant Clinic of Pulmonology, University Hospital of Zurich","RECRUITING","Zurich","Canton of Zurich","8091","Switzerland","CH",{"type":67,"coordinates":68},"Point",[69,70],8.55,47.36667,{"lat":70,"lon":69},[73,74,75,76,78],{"name":48,"role":49,"phone":51,"phoneExt":51,"email":52},{"name":54,"role":49,"phone":55,"phoneExt":51,"email":56},{"name":48,"role":45,"phone":51,"phoneExt":51,"email":51},{"name":54,"role":77,"phone":51,"phoneExt":51,"email":51},"SUB_INVESTIGATOR",{"name":79,"role":77,"phone":51,"phoneExt":51,"email":51},"Alessandro Vella, Cand. PhD",{"type":81,"investigatorFullName":44,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":51,"oldOrganization":51},"SPONSOR_INVESTIGATOR","PD Dr. med.","100626126","effect-of-acute-hypoxia-on-right-ventricular-function-in-asthma-100626126",false,"NCT07431580","Effect of Acute Hypoxia on RIght VEntRicular Function in Asthma.","Effect of Acute Hypoxia on RIght VEntRicular Function. A Single-Center, Double-Blind, Randomized Controlled Cross-Over Trial.","RIVER-Asthma","Inclusion Criteria:\n\n* Signed informed consent\n* Diagnosed and well controlled asthma bronchiale\n* 18-80 years (age group young: 18-39.99 years \u002F age group older: 40-80 years)\n* All sex and genders\n* Living \\\u003C800m and without altitude exposure \\> 2500 m and \\> 24h within the last three weeks\n\nExclusion Criteria:\n\n* \\\u003C18, \\>80 years old\n* Any other diagnosed cardiopulmonary condition including past HAPE\n* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)\n* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders\n* Participants permanently living \\>800m and altitude exposure \\> 2500 m and \\>24h within the last three weeks\n* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy\n* Lactating women\n* Participation in other study with active treatment","ALL","18 Years","80 Years",{"count":95,"type":96},18,"ESTIMATED","INTERVENTIONAL",[99],"NA","More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with asthma responds to this stress is still not well understood.\n\nTherefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity in patients with asthma. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability.\n\nIn addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The \"altitude\" is simulated using a special gas mixture that participants inhale. Participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random.\n\nThe aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.",[102,103,35,104],"Hypoxia, Altitude","Hypoxia","Right Ventricular Function",[106,107,108,109,110,111,112],"right ventricular free wall strain","RVFWS","right ventricular function","tissue oxygenation","breathing difficulty","blood gas","heart rate","2026-05-26",{"date":115,"type":116},"2026-05-29","ACTUAL",{"date":113,"type":116},{"date":119,"type":96},"2030-01",{"name":44,"class":6},1]