[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634181":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":36,"centralContacts":40,"locations":29,"responsibleParty":50,"collaborators":29,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":29,"enrollmentInfo":63,"targetDuration":29,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":77,"whyStopped":29,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":29},{"fullName":5,"class":6},"Beni-Suef University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"group (A) threshold inspiratory muscle training","ACTIVE_COMPARATOR","threshold inspiratory muscle training: threshold inspiratory muscle training in addition to conventional chest physiotherapy. The TIMT device will be connected to an endotracheal tube and will be verified to be reliable for inspiratory muscle training. With patient in 45 supine position, he will instructed to exhale slowly, empty the air in the lungs and then inhale deeply and vigorously as fast as possible. The MIP will recorded. The inspiratory resistance is set at 50% of MIP. When the heart rate, pulse oxygen, and respiratory rate are relatively stable during inspiratory training, the inspiratory resistance will be increased by 1-2 cm H2O per day. the resistance will be adjusted every day to be 50% of the new maximum inspiratory pressure then 1-2 cm H2O added. Each patient performed 6 breaths × five sets × twice daily × 5 days\u002F week. Until patients are weaned from mechanical ventilation.",[13],"Device: threshold inspiratory muscle training + conventional chest physiotherapy",{"label":15,"type":10,"description":16,"interventionNames":17},"group (B) PNF training + IMT","PNF training: in the form of rhythmic initiation technique (RIT) and initial stretch technique (IST) in addition to TIMT plus Conventional Chest Physiotherapy. The RIT performed to teach coordination of motion and to establish the correct breathing pattern. The IST applied to reinforce the strength of inspiratory muscles. Its main aim is to facilitate the initiation of motion . PNF techniques include two sessions per day, 5 days\u002Fweek until patients are weaned from mechanical ventilation. Including four 90-second manual stimulations each (upper ribs, lower ribs, sternum, and diaphragm). After every stimulation the patient rested for one minute.",[18],"Device: proprioceptive neuromuscular facilitation + threshold inspiratory muscle training + conventional chest physiotherapy",{"label":20,"type":10,"description":21,"interventionNames":22},"group(C) Conventional Chest Physiotherapy only","Conventional Chest Physiotherapy only: two sessions per day, 5 days\u002Fweek which included Vibration, Percussion, hyperinflation, and suctioning if indicated until patients are weaned from mechanical ventilation.",[23],"Other: Conventional Chest Physiotherapy",[25,30,33],{"type":26,"name":27,"description":11,"armGroupLabels":28,"otherNames":29},"DEVICE","threshold inspiratory muscle training + conventional chest physiotherapy",[9],null,{"type":26,"name":31,"description":16,"armGroupLabels":32,"otherNames":29},"proprioceptive neuromuscular facilitation + threshold inspiratory muscle training + conventional chest physiotherapy",[15],{"type":6,"name":34,"description":21,"armGroupLabels":35,"otherNames":29},"Conventional Chest Physiotherapy",[20],[37],{"name":38,"affiliation":5,"role":39},"Sherine H Mehani, professor","PRINCIPAL_INVESTIGATOR",[41,46],{"name":42,"role":43,"phone":44,"phoneExt":29,"email":45},"Mohammed SH Attya, master degree","CONTACT","+201158268850","mohammedbnshaaban2@gmail.com",{"name":47,"role":43,"phone":48,"phoneExt":29,"email":49},"Mahmoud I Mahmoud, lecturer","00201142998414","Mahmoud.ibrahim@pt.bsu.edu.eg",{"type":39,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Mohammed Shaaban Attya Abd-Alhafez","demonstrator","100634181","effect-of-adding-pnf-to-imt-on-weaning-off-mv-100634181",false,"NCT07536347","Effect of Adding PNF to IMT on Weaning Off MV","Effect of Adding Proprioceptive Neuromuscular Facilitation to Inspiratory Muscle Training on Weaning Off Mechanical Ventilation","PNF\u002FIMT\u002FMV","Inclusion Criteria:\n\n* Adults of both sexes\n* patients older than 18 years\n* Conscious and cooperative\n* Hemodynamic stability without significant vasopressor support.\n* No continuous sedation.\n* Mechanically ventilated due to type 1 or type 2 respiratory failure (RF) for at least 24 hours.\n* Mechanically ventilated in assisted ventilation mode\n* Are able to participate in training actively, weanable as regard shallow breathing index.\n* presence of weaning criteria as defined in the European Consensus Conference in 2007, including sedation reduction, spontaneous breathing cycles, Partial pressure of oxygen (PaO2)\u002F fraction of inspired oxygen (FiO2) ≥ 150, absence of inotropes or vasopressors at high doses or increasing doses (\\\u003C 1 mg\u002Fh), oxy-hemoglobin saturation (SaO2) \\> 90% with FiO2≤ 50%, positive end expiratory pressure (PEEP) ≤ 8 cmH2O, temperature between 36 and 39 °C.\n\nExclusion Criteria:\n\n* Hemodynamic or respiratory instability\n* Condition that can compromise weaning, such as heart failure.\n* Condition that can prevent adequate performance of inspiratory muscle training, such as neuropathy or myopathy.\n* Thoracic or abdominal surgery precluding the use of PNF exercises\n* Rib fractures\n* Current pregnancy\n* Cardiac arrest with a guarded neurological prognosis\n* Deep coma","ALL","18 Years",{"count":64,"type":65},93,"ESTIMATED","INTERVENTIONAL",[68],"NA","the goal of this clinical trial is to find out the effect of adding proprioceptive neuromuscular facilitation to inspiratory muscle training on weaning off mechanical ventilation. the main question it aims to answer is is there a significant difference in the effect of inspiratory muscle training combined with PNF on the duration of weaning in the mechanically ventilated ICU patients.\n\nresearchers will compare effect of (Inspiratory muscle training combined with PNF) to (Inspiratory muscle training) and control group.\n\nparticipants will be mechanically ventilated both sexes patients will be recruited in this study from intensive care unit, their ages older than 18 years. The selected patients will be mechanically ventilated due to respiratory failure and will randomly assigned into three equal groups.",[71],"Weaning From Mechanical Ventilation",[73,74,75,76],"proprioceptive neuromuscular facilitation","weaning","Inspiratory muscle training","diaphragmatic excretion","NOT_YET_RECRUITING","2026-04-11",{"date":80,"type":81},"2026-04-17","ACTUAL",{"date":83,"type":65},"2026-04-25",{"date":85,"type":65},"2026-12-01",{"name":5,"class":6}]