[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644552":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":41,"locations":26,"responsibleParty":47,"collaborators":26,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":26,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":26,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":78,"whyStopped":26,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":26},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Study group","EXPERIMENTAL","10 patients with mandibular fracture will be treated by application of adipose tissue derived MSCs concentrate on fracture line before and following fixation with titanium plates and screws.",[13],"Procedure: Adipose tissue derived mesenchymal stem cells concentrate application in addition to the open reduction and internal fixation.",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","ACTIVE_COMPARATOR","10 patients with mandibular fracture will be treated by open reduction and internal fixation with titanium plates and screws.",[19],"Procedure: Open reduction and internal fixation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Adipose tissue derived mesenchymal stem cells concentrate application in addition to the open reduction and internal fixation.","Abdominal fat liposuction will be carried out, microfragmentation of adipose tissue will be performed. Then the filtrate containing mesenchymal stem cells concentrate will be applied to the fracture line before and following fixation with titanium plates and screws .",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Open reduction and internal fixation","Open reduction and internal fixation of fracture line with titanium plates and screws",[15],[32,36,39],{"name":33,"affiliation":34,"role":35},"Mostafa Mohamed El-Gangehi, Professor","Faulty of Dentistry, Cairo University","STUDY_CHAIR",{"name":37,"affiliation":34,"role":38},"Walaa Kadry, Associate Professor","STUDY_DIRECTOR",{"name":40,"affiliation":34,"role":35},"Sameh Mekhemer, Professor",[42],{"name":43,"role":44,"phone":45,"phoneExt":26,"email":46},"Mona Mahmoud Abdulhameed","CONTACT","00201001249384","monamabdulhameed@gmail.com",{"type":48,"investigatorFullName":43,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Principal Investigator","100644552","effect-of-adipose-tissue-derived-autologous-mesenchymal-stem-cell-concentrate-on-bone-quality-in-mandibular-fracture-healing-100644552",false,"NCT07671183","Effect of Adipose Tissue Derived Autologous Mesenchymal Stem Cell Concentrate on Bone Quality in Mandibular Fracture Healing.","Bone Quality Assessment Following Application of Adipose Tissue Derived Autologous Mesenchymal Stem Cell Concentrate in the Management of Mandibular Fractures. A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients with mandibular fracture.\n* Patients who are willing to participate in the study\n\nExclusion Criteria:\n\n* Patients with systemic diseases influence bone healing\n* Patients with pathological fractures.\n* Infection located at the zone to be treated","ALL","18 Years","40 Years",{"count":61,"type":62},20,"ESTIMATED","INTERVENTIONAL",[65],"NA","* The goal of study is to evaluate the effectiveness of adipose tissue derived-MSCs concentrate application in mandibular fractures. The main question it aims to answer is: Does intervention enhance bone quality, reduce complications and reduce bone regeneration time.\n* Researchers will compare the effectiveness of adipose tissue derived-MSCs concentrate application with ORIF to ORIF alone to see if MSCs improve healing in mandibular fractures.\n* Participants will:\n\n  * Be managed either by adipose tissue derived-MSCs concentrate application with ORIF or ORIF alone.\n  * Undergo CBCT immediately (T1) and 3 months (T4) postoperatively for bone density radiographic evaluation\n  * Visit the clinic postoperatively at one week (T2), one month (T3), three months (T4) for clinical examination",[68],"Mandible Fracture",[70,71,72,73,74,75,76,77],"bone quality","bone healing","mandibular fractures","mesenchymal stem cells","randomized clinical trial","fracture repair","bone regeneration","regenerative medicine","NOT_YET_RECRUITING","2026-06-25",{"date":81,"type":82},"2026-06-29","ACTUAL",{"date":84,"type":62},"2026-07",{"date":86,"type":62},"2027-02",{"name":5,"class":6}]