[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636401":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":29,"locations":24,"responsibleParty":35,"collaborators":24,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":24,"eligibilityCriteria":43,"healthyVolunteers":44,"sex":45,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":24,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":60,"whyStopped":24,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":24},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"dlPFC TMS","EXPERIMENTAL","Individualized left dlPFC targets will be identified using task-based fMRI activation during the baseline Sternberg. BOLD activity maps from the retention interval will be masked with a left dlPFC region of interest defined from a group-level analysis of an independent Sternberg dataset. Activity will be contrasted between sort and maintain conditions, and the peak voxel within this mask will be extracted as the individualized target.",[13],"Device: TBS",{"label":15,"type":10,"description":16,"interventionNames":17},"TPJ TMS","Individualized left TPJ targets will be identified using task-based fMRI activation during the baseline Sternberg. BOLD activity maps from the retention interval will be masked with a left TPJ region of interest defined from a group-level analysis of an independent Sternberg dataset. Activity will be contrasted between sort and maintain conditions, and the peak negative voxel within this mask will be extracted as the individualized target.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","TBS","aiTBS stimulation parameters. A MagVenture MagPro 100X stimulator with a B65 figure-8 coil will be used for the aiTBS sessions. A series of 20, 10 s trains will be presented over the course of the \\~3.5 min session. Each train will consist of 2 s of stimulation with an 8 s ITI. During the 2 s of stimulation, 10, 50 Hz bursts will be repeated at intervals of 200 ms (5 Hz).",[15,9],null,[26],{"name":27,"affiliation":5,"role":28},"Nicholas L Balderston, PhD","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Nicholas Balderston","CONTACT","12157463058","nicholas.balderston@pennmedicine.upenn.edu",{"type":36,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100636401","effect-of-aitbs-on-intrinsic-spectral-dynamics-and-task-performance-100636401",false,"NCT07565207","Effect of aiTBS on Intrinsic Spectral Dynamics and Task Performance","The Effect of Within-network aiTBS on Cortical Excitability, Intrinsic Oscillatory Bands, and Behavioral Task Performance","Inclusion Criteria:\n\n* Able to give their consent\n* Right-handed or ambidextrous\n\nExclusion Criteria:\n\n* Non-english speaking\n* Current or past non-anxiety-related psychiatric comorbidity.\n* Active or history of active suicidal ideation\n* Alcohol\u002Fdrug problems in the past year or lifetime alcohol or drug dependence\n* Medications that act on the central nervous system\n* History of seizure\n* History of epilepsy\n* Increased risk of seizure for any reason\n* Pregnancy, or positive pregnancy test\n* Any medical (e.g., stroke, breathing problems, motion disorders) or neurological (e.g., a significant brain injury or brain infection history that increases seizure risk) condition that increases risk for fMRI or TMS (Protocol will follow recommendations from Rossi et al. 2021 doi:10.1016\u002Fj.clinph.2020.10.003)\n* Any metal in their body which would make having an MRI scan unsafe\n* Any sort of medical implants\n* Hearing loss\n* Claustrophobia\n* orthostatic hypotension",true,"ALL","18 Years","50 Years",{"count":49,"type":50},80,"ESTIMATED","INTERVENTIONAL",[53],"NA","Aim 1: Measure local shifts in cortical spectral dynamics following aiTBS. Aim 2: Measure network-specific shifts in task performance following aiTBS. Exploratory aim: Evaluate changes to resting state spectral dynamics in absence of stimulation after aiTBS.",[56],"Brain Plasticity",[58,59],"transcranial magnetic stimulation","electroencephalography","NOT_YET_RECRUITING","2026-04-27",{"date":63,"type":64},"2026-05-04","ACTUAL",{"date":66,"type":50},"2026-06-01",{"date":68,"type":50},"2030-05-30",{"name":5,"class":6}]