[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642756":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":10,"responsibleParty":30,"collaborators":10,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":38,"acronym":39,"eligibilityCriteria":40,"healthyVolunteers":36,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":10,"studyType":47,"phases":10,"briefSummary":48,"conditions":49,"keywords":10,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":10},{"fullName":5,"class":6},"Kanuni Sultan Suleyman Training and Research Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Alexithymia-Positive Cohort",null,"Participants with knee osteoarthritis who have a Toronto Alexithymia Scale-20 (TAS-20) score of 61 or higher at baseline. All participants will receive the same standardized physical therapy program and will be followed prospectively to evaluate treatment response.",[13],"Procedure: Standard Physical Therapy Program",{"label":15,"type":10,"description":16,"interventionNames":17},"Alexithymia-Negative Cohort","Participants with knee osteoarthritis who have a Toronto Alexithymia Scale-20 (TAS-20) score of less than 61 at baseline. All participants will receive the same standardized physical therapy program and will be followed prospectively to evaluate treatment response.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"PROCEDURE","Standard Physical Therapy Program","All participants will receive the same standardized physical therapy program consisting of:\n\nTranscutaneous Electrical Nerve Stimulation (TENS) for 20 minutes, Superficial heat therapy (hot pack) for 20 minutes, Therapeutic ultrasound (1 MHz, 1.5 W\u002Fcm²) for 5 minutes, A home exercise program targeting the muscles around the knee.\n\nThe treatment will be administered 5 days per week for 3 weeks, for a total of 15 sessions.",[15,9],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Zeynep Karakuzu Güngör, M.D","CONTACT","+90 212 404 15 00","zeynepkarakuzu@hotmail.com.tr",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Zeynep Karakuzu Güngör","Specialist in Physical Medicine and Rehabilitation","100642756","effect-of-alexithymia-on-response-to-physical-therapy-in-patients-with-knee-osteoarthritis-100642756",false,"NCT07651410","Effect of Alexithymia on Response to Physical Therapy in Patients With Knee Osteoarthritis","ALEX-KOA","Inclusion Criteria:\n\nAge between 40 and 75 years. Diagnosis of knee osteoarthritis according to the American College of Rheumatology (ACR) criteria.\n\nKellgren-Lawrence grade II or III on radiographic evaluation. Presence of symptomatic knee pain requiring physical therapy. Willingness and ability to participate in the standardized physical therapy program.\n\nAbility to complete study questionnaires and clinical assessments. Provision of written informed consent prior to participation.\n\nExclusion Criteria:\n\nAge younger than 40 years or older than 75 years. Kellgren-Lawrence grade I or grade IV knee osteoarthritis. Previous knee arthroplasty or major knee surgery on the affected side. Lower extremity surgery within the previous 6 months. Intra-articular corticosteroid, hyaluronic acid, platelet-rich plasma, prolotherapy, or stem cell injection into the knee within the previous 3 months.\n\nPhysical therapy for knee osteoarthritis within the previous 3 months. Acute knee trauma or fracture. Inflammatory rheumatic diseases (e.g., rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis).\n\nFibromyalgia or chronic widespread pain syndrome. Active infection or malignancy. Neurological disorders significantly affecting lower extremity function or balance (e.g., stroke, Parkinson's disease, multiple sclerosis).\n\nSevere cognitive impairment or major psychiatric illness that may interfere with study participation or questionnaire completion.\n\nContraindications to physical therapy modalities (TENS, therapeutic ultrasound, or superficial heat therapy).\n\nRegular opioid analgesic use or other medications that may substantially influence pain perception.\n\nPregnancy or breastfeeding. Inability to comply with the treatment protocol or follow-up assessments. Participation in another interventional clinical study during the study period. Refusal or inability to provide written informed consent.\n\n\\-","ALL","40 Years","75 Years",{"count":45,"type":46},60,"ESTIMATED","OBSERVATIONAL","Knee osteoarthritis is one of the most common degenerative joint diseases and is associated with chronic pain, functional impairment, and reduced quality of life. Psychological factors may influence both symptom severity and response to treatment. Alexithymia, characterized by difficulty in identifying and expressing emotions, has been associated with poorer outcomes in chronic pain conditions.\n\nThe aim of this prospective observational study is to investigate whether the presence of alexithymia affects the clinical response to a standardized physical therapy program in patients with knee osteoarthritis. Participants will undergo a standard physical therapy regimen and will be evaluated before treatment, immediately after treatment, and 6 weeks after treatment completion. Pain, functional status, alexithymia, anxiety, and depression will be assessed using validated clinical scales. The study seeks to determine whether alexithymia is an independent predictor of treatment response in patients with knee osteoarthritis.",[50],"Knee Osteoarthritis","NOT_YET_RECRUITING","2026-06-11",{"date":54,"type":55},"2026-06-16","ACTUAL",{"date":57,"type":46},"2026-06-25",{"date":59,"type":46},"2026-11-01",{"name":5,"class":6}]