[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630704":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":34,"centralContacts":35,"locations":45,"responsibleParty":59,"collaborators":61,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":34,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":94,"whyStopped":34,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Institut de Recherches Cliniques de Montreal","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Cold exposure","EXPERIMENTAL","Participants will be exposed to cold temperature (10°C\u002F50°F) in an environmental chamber for 120 minutes while seated. This temperature is designed to induce shivering thermogenesis and increase energy expenditure by approximately 80%. The cold exposure may slow insulin absorption from subcutaneous injection sites due to reduced skin blood flow and vasoconstriction. Participants will wear standard clothing (shorts and t-shirt) with optional socks and gloves if needed for comfort. Continuous monitoring includes core body temperature via rectal probe, skin temperature at four sites, heart rate, blood pressure every 10 minutes, and blood glucose via continuous glucose monitor every 15 minutes. Blood samples will be collected at baseline, 60 minutes, and 120 minutes for plasma glucose, insulin, glucagon, and metabolic markers. The exposure will be terminated if core body temperature drops to ≤35.5°C.",[13],"Other: Environmental Temperature Exposure",{"label":15,"type":16,"description":17,"interventionNames":18},"Neutral Temperature","ACTIVE_COMPARATOR","Participants will be exposed to neutral room temperature (23°C\u002F73°F) in an environmental chamber for 120 minutes while seated. This condition serves as the control\u002Freference temperature representing typical indoor environmental conditions. At this temperature, normal thermoregulatory responses are minimal, allowing assessment of baseline insulin absorption and glucose responses without temperature-induced physiological stress. Participants will wear standard clothing (shorts and t-shirt) and undergo the same monitoring protocol as other arms: continuous core and skin temperature measurement, heart rate monitoring, blood pressure every 10 minutes, blood glucose monitoring every 15 minutes via continuous glucose monitor, and blood sampling at baseline, 60 minutes, and 120 minutes.",[13],{"label":20,"type":10,"description":21,"interventionNames":22},"Hot\u002FHumid Exposure","Participants will be exposed to hot and humid conditions (36°C\u002F97°F with 65% relative humidity) in an environmental chamber for 120 minutes while seated. These conditions simulate a hot summer day in Montreal and are designed to increase skin blood flow through vasodilation, potentially accelerating insulin absorption from subcutaneous depot sites. The combination of heat and humidity will induce thermal stress and sweating responses. Participants will wear standard clothing (shorts and t-shirt) with access to water as needed. The same comprehensive monitoring protocol applies: continuous measurement of core body temperature, skin temperature at four body sites, heart rate, blood pressure every 10 minutes, and blood glucose every 15 minutes. Blood samples will be collected at baseline, 60 minutes, and 120 minutes. The exposure will be terminated if core body temperature reaches ≥39.5°C.",[13],[24],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"Environmental Temperature Exposure","Systematic exposure to controlled temperature and humidity conditions in a specialized environmental chamber. Each exposure lasts 120 minutes with participants remaining seated throughout. All exposures include standardized pre-exposure preparation (60-minute baseline period at room temperature), continuous physiological monitoring, standardized clothing, and identical blood sampling schedules. Safety protocols include continuous staff supervision, predetermined stopping criteria for extreme body temperatures or blood pressure changes, and immediate availability of warming\u002Fcooling interventions and hypoglycemia treatment protocols.",[9,20,15],[29,30,31,32,33],"Temperature Stress Testing","Thermal Exposure Protocol","Environmental Chamber Study","Ambient Temperature Intervention","Temperature-Insulin Absorption Study",null,[36,41],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},"Corinne Suppere, MSc","CONTACT","514-987-5597","corinne.suppere@ircm.qc.ca",{"name":42,"role":38,"phone":43,"phoneExt":34,"email":44},"Jane Yardley, PhD","514-987-5568","jane.yardley@ircm.qc.ca",[46],{"facility":47,"status":34,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":34},"Institut de recherches cliniques de Montréal","Montreal","Quebec","H2W 1R7","Canada","CA",{"type":54,"coordinates":55},"Point",[56,57],-73.58781,45.50884,{"lat":57,"lon":56},{"type":60,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR",[62,65],{"name":63,"class":64},"Cardiometabolic Health, Diabetes and Obesity Research Network","UNKNOWN",{"name":66,"class":64},"Centre EPIC","100630704","effect-of-ambient-temperature-on-blood-glucose-and-insulin-absorption-in-adults-with-type-1-diabetes-100630704",false,"NCT07491133","Effect of Ambient Temperature on Blood Glucose and Insulin Absorption in Adults With Type 1 Diabetes","Effect of Ambient Temperature on Insulin Absorption and Change in Blood Glucose Levels in Individuals With Type 1 Diabetes","T1Temp","Inclusion Criteria:\n\n* Diagnosis of type 1 diabetes for more than 2 years\n* Ability to provide verbal and written informed consent\n* Ability to speak and understand French\n\nExclusion Criteria:\n\n* Recent and\u002For unstable health condition (less than 3 months) prior to enrolment\n* Any viral infection at time of participation\n* Chronic illness other than type 1 diabetes (for example: pulmonary disease, cardiovascular disease, cancer)\n* Health condition not controlled by medication\n* Pregnancy or breastfeeding (for female participants)\n* Any other health condition deemed to pose undue health risks during participation in the study","ALL","18 Years","45 Years",{"count":79,"type":80},30,"ESTIMATED","INTERVENTIONAL",[83],"NA","The goal of this clinical trial is to learn how different temperatures affect blood sugar levels in adults with type 1 diabetes. Climate change is causing more extreme hot and cold weather, and people with type 1 diabetes may be at higher risk during these temperature changes. The main questions it aims to answer are:\n\n* Do different temperatures (cold, normal, or hot) change blood sugar levels in people with type 1 diabetes?\n* How does temperature affect insulin absorption in the body?\n\nResearchers will compare three different temperature conditions to see how each affects blood sugar levels and insulin in the body.\n\nParticipants will:\n\n* Complete a screening visit with body measurements and questionnaires\n* Attend 3 separate study visits, each in a different temperature setting:\n* Cold room (10°C\u002F50°F)\n* Normal room temperature (23°C\u002F73°F)\n* Hot and humid room (36°C\u002F97°F with 65% humidity)\n* Sit for 2 hours in each temperature condition while researchers monitor their blood sugar, heart rate, and body temperature\n* Wear a continuous glucose monitor for 48-72 hours before each visit\n* Keep a diary of food, sleep, and activity for 24 hours before and after each visit\n\nEach temperature visit is separated by at least 3 days. The study helps researchers understand if people with type 1 diabetes need special guidance for managing their blood sugar during extreme weather.",[86],"Type 1 Diabetes Mellitus",[88,89,90,91,92,93],"Type 1 diabetes","Insulin absorption","Temperature exposure","Blood glucose","Continuous glucose monitoring","Hypoglycemia","NOT_YET_RECRUITING","2026-03-18",{"date":97,"type":98},"2026-03-24","ACTUAL",{"date":100,"type":80},"2026-03",{"date":102,"type":80},"2027-07",{"name":5,"class":6},1]