[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623196":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":26,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":26,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":26,"enrollmentInfo":62,"targetDuration":26,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Osijek University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Apneic Oxygenation","EXPERIMENTAL","Patients receive apneic oxygenation of non-ventilated lung during lung cancer surgery.",[13],"Procedure: Apnoeic Oxygenation",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","ACTIVE_COMPARATOR","Patients receive standard ventilation during lung cancer surgery.",[19],"Procedure: Standard Ventilation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Apnoeic Oxygenation","Apneic oxygenation of the non-ventilated lung is applied during lung cancer surgery to maintain oxygenation and decrease inflammatory response while the lung is not mechanically ventilated.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Standard Ventilation","Standard ventilation is applied during lung cancer surgery according to routine clinical practice.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Hrvoje Vinković, MD, PhD candidate","CONTACT","+385 98 810 375","hrvoje.vinkovic@kbco.hr",[38],{"facility":39,"status":40,"city":41,"state":26,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":26},"University Hospital Center Osijek","RECRUITING","Osijek","31000","Croatia","HR",{"type":46,"coordinates":47},"Point",[48,49],18.6942,45.55066,{"lat":49,"lon":48},{"type":52,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100623196","effect-of-apneic-oxygenation-of-the-non-ventilated-lung-during-lung-cancer-surgery-100623196",false,"NCT07393490","Effect of Apneic Oxygenation of the Non-ventilated Lung During Lung Cancer Surgery.","The Effect of Apneic Oxygenation of the Non-ventilated Lung on the Expression of Hypoxia-inducible Factor-1 Alpha (HIF-1α) and Interleukin-6 (IL-6) in Lung Tissue During Lung Cancer Surgery.","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Patients scheduled to undergo surgical resection of a single lung segment for lung cancer\n* Written informed consent provided\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Chronic corticosteroid therapy and\u002For other immunomodulatory treatments\n* Severe pulmonary diseases, including:\n\nChronic obstructive pulmonary disease classified as GOLD stage 3-4 (Global Initiative for Chronic Obstructive Lung Disease).\n\nSevere asthma according to GINA classification (Global Initiative for Asthma), step 4.\n\nSevere interstitial lung disease defined by: Forced vital capacity (FVC) \\\u003C 50% predicted, diffusing capacity of the lung for carbon monoxide (DLCO) \\\u003C 40% predicted, presence of extensive pulmonary fibrosis on computed tomography (CT)\n\n* Surgical procedure expected to last less than 2 hours\n* Intraoperative hemodynamic instability, defined as: Mean arterial pressure \\\u003C 60 mmHg for more than 30 minutes despite adequate volume resuscitation, requirement for high-dose vasopressor support (norepinephrine \\> 0.2 µg\u002Fkg\u002Fmin)\n* New-onset intraoperative cardiac arrhythmias\n* Significant intraoperative blood loss, defined as the need for transfusion of more than two units of packed red blood cells\n* Intraoperative ventilatory instability, defined as: Severe hypoxemia (PaO₂ \\\u003C 60 mmHg or SpO₂ \\\u003C 85% with FiO₂ 1.0), hypercapnia (PaCO₂ \\> 70 mmHg with pH \\\u003C 7.2), inability to achieve adequate ventilation.","ALL","18 Years",{"count":63,"type":64},56,"ESTIMATED","INTERVENTIONAL",[67],"NA","This study investigates the effect of apneic oxygenation of the non-ventilated lung on local and systemic inflammatory response during lung cancer surgery.\n\nPatients undergoing surgical resection of lung cancer often require one-lung ventilation during anaesthesia. This results in alveolar hypoxia accompanied by upregulated expression of inflammatory markers. Apneic oxygenation of the non-ventiladed lung may influence inflammatory processes and oxygenation during surgery. The aim of this study is to evaluate whether apneic oxygenation affects inflammatory markers in lung tissue and postoperative recovery in patients undergoing lung cancer surgery. The study is conducted at a single center and includes adult patients scheduled for elective lung cancer surgery. Data will be collected durig the perioperative period. The results of this study may contribute to improved anaesthetic management and patient outcomes during thoracic surgery.",[70],"Lung Cancer (Diagnosis)",[72,73,74,75,76,77],"One-lung ventilation","Apneic oxygenation","Inflammatory response","Hif 1 alpha","Interleukin 6","Thoracic anaesthesia","2026-06-24",{"date":80,"type":81},"2026-06-26","ACTUAL",{"date":83,"type":81},"2025-01-02",{"date":85,"type":64},"2026-09",{"name":5,"class":6},1]