[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598264":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":24,"locations":12,"responsibleParty":30,"collaborators":12,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":38,"acronym":12,"eligibilityCriteria":39,"healthyVolunteers":40,"sex":41,"minAge":12,"maxAge":12,"enrollmentInfo":42,"targetDuration":12,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":12,"overallStatus":51,"whyStopped":12,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":12},{"fullName":5,"class":6},"Universita degli Studi di Genova","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Machined Abutment - control","NO_INTERVENTION","The control group received MUA without plasma treatment.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Plasma abutment - test","EXPERIMENTAL",".The MUA allocated to the test group will be placed in a plasma reactor (Plasmapp, South Korea) for decontamination and activation of the surface. In order to restrict any post-treatment contamination; abutments will be inserted immediately after the end of the plasma process.",[18],"Device: the test group were placed in an Argon plasma reactor",[20],{"type":21,"name":22,"description":22,"armGroupLabels":23,"otherNames":12},"DEVICE","the test group were placed in an Argon plasma reactor",[14],[25],{"name":26,"role":27,"phone":28,"phoneExt":12,"email":29},"Luigi Canullo","CONTACT","+39393476201976‬","luigicanullo@yahoo.com",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","Paolo Pesce","Prof.","100598264","effect-of-bio-activation-on-epithelial-and-connective-cell-adhesion-to-titanium-abutments-split-mouth-clinical-trial-100598264",false,"NCT07069231","Effect of Bio-activation on Epithelial and Connective Cell Adhesion to Titanium Abutments: Split Mouth Clinical Trial","Inclusion Criteria:\n\n* presence of at least 4 mm of keratinized mucosa around the implants,\n* patients aged 18 years or older\n* medically healthy patients (ASA I), or patients with mild systemic disease (ASA II)\n* Total or partial edentulous state with space for at least 2 implants\n\nExclusion Criteria:\n\n* ASA physical status 3\n* severe smokers (\\> 10 cig\u002Fday)\n* patients undergoing bisphosphonate therapy\n* pregnant or lactating women\n* estrogen-related hormonal disorders or hormonal substitution therapy patients with a history of head and neck cancers and radiotherapy in this region",true,"ALL",{"count":43,"type":44},20,"ESTIMATED","INTERVENTIONAL",[47],"NA","The aim of this \"in vivo\" controlled trial is to assess soft tissue cell adhesion to titanium abutments subjected to different cleaning procedures - no treatment (as they come from the industry), and cleaning by plasma- at an early healing time.\n\nIn fact, the primary aim is Quantity and Quality of soft tissue adhesion at the microscopic level (e.g Fibronectin, Integrin-actin).\n\nThe secondary Aim - Clinical parameters and outcomes - BOP, PPD, MBL (Marginal Bone Level to check influence of plasmapp-treated abutments).\n\nThe null hypothesis of the study was that the cleaning procedure applied to implant abutments has no effect on soft tissue cell adhesion and MBL at an early healing time.",[50],"Missing Tooth\u002FTeeth","NOT_YET_RECRUITING","2025-07-05",{"date":54,"type":55},"2025-07-16","ACTUAL",{"date":57,"type":44},"2025-07-15",{"date":59,"type":44},"2025-10-30",{"name":5,"class":6}]