[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637173":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":27,"centralContacts":31,"locations":41,"responsibleParty":59,"collaborators":24,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":24,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":84,"whyStopped":24,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"General Hospital of Ningxia Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"a single-injection adductor canal block","EXPERIMENTAL","An ultrasound-guided adductor canal block is performed via the conventional adductor canal approach. Under ultrasound guidance, 20 milliliters of 1.33% bupivacaine liposome is injected into the adductor canal.",[13],"Procedure: a single-injection adductor canal block",{"label":15,"type":16,"description":17,"interventionNames":18},"continuous femoral nerve block","ACTIVE_COMPARATOR","An ultrasound-guided perineural sheath block of the femoral nerve is performed via the conventional femoral nerve approach. A femoral nerve catheter is then placed and connected to an analgesia pump containing 150 milliliters of 0.20% ropivacaine.",[19],"Procedure: continuous femoral nerve block",[21,25],{"type":22,"name":9,"description":11,"armGroupLabels":23,"otherNames":24},"PROCEDURE",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":26,"otherNames":24},[15],[28],{"name":29,"affiliation":5,"role":30},"Xinli Ni","STUDY_CHAIR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":24,"email":36},"Xin li Ni, MD","CONTACT","13909586966","xinlii6@nyfy.com.cn",{"name":38,"role":34,"phone":39,"phoneExt":24,"email":40},"Qiaojiang Shen","17829917323","2832394521@qq.com",[42],{"facility":43,"status":24,"city":44,"state":45,"zip":24,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"General hospital of Ningxia medical university","Yinchuan","Ningxia","China","CN",{"type":49,"coordinates":50},"Point",[51,52],106.27306,38.46806,{"lat":52,"lon":51},[55],{"name":56,"role":34,"phone":57,"phoneExt":24,"email":58},"Xinli Ni, MD","86-0951-6743252","xinlini6@nyfy.com.cn",{"type":60,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100637173","effect-of-bupivacaine-liposome-injection-on-muscle-strength-after-total-knee-arthroplasty-100637173",false,"NCT07616102","Effect of Bupivacaine Liposome Injection on Muscle Strength After Total Knee Arthroplasty","Effect of Bupivacaine Liposome Adductor Canal Block on Muscle Strength After Total Knee Arthroplasty.","TKA","Inclusion Criteria:\n\n1. Patients aged 60-75 years scheduled for elective TKA;\n2. ASA physical status classification II-III;\n3. BMI 18-30 kg\u002Fm²;\n4. Agreement to participate in this study and provision of signed informed consent.\n\nExclusion Criteria:\n\n1. Individuals with communication barriers such as language or hearing impairments;\n2. Patients with contraindications to nerve blocks;\n3. Severe systemic diseases, such as severe renal disease (estimated glomerular filtration rate below 50 mL\u002Fmin), cardiac disease (congestive heart failure New York Heart Association Class III to IV), or severe hepatic disease defined as a current or past diagnosis of acute\u002Fsubacute hepatic necrosis, acute liver failure, chronic liver disease, liver abscess, hepatic coma, or hepatorenal syndrome;\n4. History of long-term opioid use (defined as daily or nearly daily opioid use within the past 3 months).","ALL","60 Years","75 Years",{"count":73,"type":74},80,"ESTIMATED","INTERVENTIONAL",[77],"NA","This study employs a randomized controlled trial to investigate whether bupivacaine liposome injection for adductor canal block can effectively improve lower limb muscle strength after total knee arthroplasty.",[67,80],"Muscle Strength",[82,83,67,80],"Bupivacaine Liposome","Adductor Canal Block","NOT_YET_RECRUITING","2026-05-26",{"date":87,"type":88},"2026-05-29","ACTUAL",{"date":90,"type":74},"2026-06-10",{"date":92,"type":74},"2026-11-03",{"name":5,"class":6},1]