[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100486546":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":12,"locations":12,"responsibleParty":24,"collaborators":12,"id":26,"slug":27,"hasResults":28,"nctId":29,"briefTitle":30,"officialTitle":31,"acronym":12,"eligibilityCriteria":32,"healthyVolunteers":28,"sex":33,"minAge":34,"maxAge":35,"enrollmentInfo":36,"targetDuration":12,"studyType":39,"phases":40,"briefSummary":42,"conditions":43,"keywords":46,"overallStatus":48,"whyStopped":12,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":12},{"fullName":5,"class":6},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","NO_INTERVENTION","The control group maintain the target blood pressure only according to the controlled hypotension guideline.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Experimental group","EXPERIMENTAL","The experimental group adjust the controlled hypotension level under the guidance of cerebral oxygen saturation monitoring.",[18],"Other: Controlled hypotension guided by cerebral oxygen saturation monitoring",[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":12},"Controlled hypotension guided by cerebral oxygen saturation monitoring","In this group, intraoperative monitoring of cerebral oxygen saturation will be used. When the cerebral oxygen saturation decreased by 20% \\~ 25% compared with the baseline for 300 seconds without improvement, or the cerebral oxygen saturation decreased by 25% \\~ 30% compared with the baseline for 180 seconds without improvement, intervention would be carried out. When the cerebral oxygen saturation decreased by 30% compared with the baseline, immediate intervention would be carried out. The intervention measures were intravenous administration of deoxyepinephrine 50 \\~ 100 μg or ephedrine 5 \\~ 10mg, which can be administered multiple times until the cerebral oxygen saturation reaches more than 80% of the baseline.",[14],{"type":25,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100486546","effect-of-cerebral-oxygen-saturation-monitoring-on-pocd-of-elderly-patients-undergoing-shoulder-arthroscopy-100486546",false,"NCT05615480","Effect of Cerebral Oxygen Saturation Monitoring on POCD of Elderly Patients Undergoing Shoulder Arthroscopy","Effect of Controlled Hypotension Guided by Cerebral Oxygen Saturation Monitoring on Postoperative Cognitive Function of Elderly Patients Undergoing Shoulder Arthroscopy","Inclusion Criteria:\n\n* Patients undergoing elective shoulder arthroscopic surgery under general anesthesia combined with brachial plexus block;\n* ASA grade ≤ grade III;\n* Patients Can communicate normally, can cooperate and complete cognitive function test;\n* Patients volunteered and signed informed consent.\n\nExclusion Criteria:\n\n* BMI \\\u003C 18 or \\> 27 kg \u002F m2;\n* Previous history of dementia, psychosis or other central nervous system diseases or mental diseases, such as cerebral infarction, stroke, Parkinson's disease, etc;\n* Patients taking sedatives or antidepressants;\n* Alcoholics or drug addicts;\n* Illiteracy, severe hearing or visual impairment;\n* Patients with cognitive impairment before operation (MMSE score \\\u003C 23);\n* Patients with peripheral vascular diseases and contraindication of arterial puncture and catheterization;\n* Patients unable to carry out long-term follow-up or poor compliance.","ALL","60 Years","79 Years",{"count":37,"type":38},400,"ESTIMATED","INTERVENTIONAL",[41],"NA","To observe whether adjusting the level of intraoperative controlled hypotension through cerebral oxygen saturation monitoring can improve postoperative cognitive function(POCD) and reduce postoperative neurological complications, a prospective randomized controlled study method will be used in this study. 400 elderly patients undergoing shoulder arthroscopic surgery under general anesthesia combined with brachial plexus block will be selected. They will be randomly divided into control group and experimental group according to whether cerebral oxygen saturation monitoring was used during the operation. The control group maintain the target blood pressure only according to the controlled hypotension guideline, and the experimental group adjust the controlled hypotension level under the guidance of cerebral oxygen saturation monitoring. The general condition, operation, anesthesia and hospitalization related data of the patients will be recorded.",[44,45],"Cerebral Oxygen Saturation","Postoperative Cognitive Function",[47],"controlled hypotension","NOT_YET_RECRUITING","2023-04-11",{"date":51,"type":52},"2023-04-13","ACTUAL",{"date":54,"type":38},"2023-05-15",{"date":56,"type":38},"2026-06-30",{"name":5,"class":6}]