[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601810":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":11,"locations":29,"responsibleParty":49,"collaborators":11,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":11,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":11,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":32,"whyStopped":11,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Tanta University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group","EXPERIMENTAL",null,[13],"Drug: Standard Allergic Rhinitis Treatment",{"label":15,"type":10,"description":11,"interventionNames":16},"Combination Group",[17],"Dietary Supplement: Combined Vitamin D and Probiotics Supplementation",[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"DRUG","Standard Allergic Rhinitis Treatment","Participants will receive standard-of-care treatment for allergic rhinitis, including oral antihistamines and\u002For intranasal corticosteroids, according to current clinical guidelines. No additional supplementation will be provided in the control group. This arm serves as the comparator for evaluating the effects of probiotic and vitamin D supplementation",[9],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"DIETARY_SUPPLEMENT","Combined Vitamin D and Probiotics Supplementation","Participants in this group will receive a combination therapy of Vitamin D3 plus a daily oral probiotic capsule containing a standardized blend of Lactobacillus and Bifidobacterium species. Both supplements will be administered once daily for 12 weeks. This intervention aims to assess the synergistic effect of vitamin D and probiotics on immune response and symptom relief in allergic rhinitis.",[15],[30],{"facility":31,"status":32,"city":33,"state":34,"zip":11,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Tanta University Hospital, ENT Department","RECRUITING","Tanta","Gharbia Governorate","Egypt","EG",{"type":38,"coordinates":39},"Point",[40,41],31.00192,30.78847,{"lat":41,"lon":40},[44],{"name":45,"role":46,"phone":47,"phoneExt":11,"email":48},"Prof. Medhat Mohammed Heshmat Mansour Professor of Otolaryngology, Tanta University","CONTACT","0020-40 3351 398","medhatmansour@hotmail.com",{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Alaa Ashraf Ahmed Abdel Hadi","Demonstrator, Clinical Pharmacy Department, Badr University in Cairo","100601810","effect-of-combined-probiotics-and-vitamin-d-on-symptoms-of-allergic-rhinitis-100601810",false,"NCT07115342","Effect of Combined Probiotics and Vitamin D on Symptoms of Allergic Rhinitis","Investigating Efficacy of Combined Probiotics and Vitamin D Supplementation in Reducing Symptoms and Improving Quality of Life in Patients With Allergic Rhinitis","Inclusion Criteria:\n\nConfirmed diagnosis of AR based on clinical history and specific IgE testing or will be screened for eligibility by the modified Mini Rhino-conjunctivitis Quality of Life Questionnaire (Mini RQLQ).\n\nPersistent rhinitis symptoms for at least two consecutive years.\n\nPresence of two or more AR symptom domains, including sneezing, watery rhinorrhea, nasal itching, and nasal congestion, with symptoms persisting or accumulating for more than 1 hour daily with \\> 2 scores without taking medication.\n\nSymptoms may be accompanied by ocular manifestations such as eye itching, tearing, and redness\n\nVoluntarily and in writing, sign an informed consent form agreeing to participate in this study and able to complete the study as required by the trial protocol.\n\nVitamin D insufficiency or deficiency. Deficiency: \\\u003C 20 ng\u002FmL (\\\u003C 50 nmol\u002FL), Insufficiency: 20-29 ng\u002FmL (50-75 nmol\u002FL)\n\nExclusion Criteria:\n\nUse of systemic corticosteroids, immunosuppressive therapy, or medications affecting the gut microbiota (antimicrobials, probiotics, prebiotics, intestinal mucosal protective agents, etc.) within 4 weeks prior to screening.\n\nRegular use of probiotics, prebiotics, or vitamin D supplements within 6 months prior to screening.\n\nHistory of or concurrent use of medications or supplements that alter serum 25(OH)D levels, such as barbiturates, bisphosphonates, sulfasalazine, anticonvulsants, antiretrovirals, omega-3 supplements, or ketoconazole.\n\nDiagnosed with pulmonary tuberculosis, allergic asthma, chronic obstructive pulmonary disease (COPD), mast cell activation syndrome, or other respiratory diseases requiring treatment.\n\nCoexisting conditions such as nasal polyps, severe nasal septum deviation, severe gastrointestinal diseases (e.g., severe diarrhea or inflammatory bowel diseases), metabolic syndrome (e.g., obesity, dyslipidemia, hypertension, diabetes), or chronic systemic diseases or malignancies.\n\nHistory of autoimmune diseases or chronic inflammatory conditions.\n\nSinusitis, otitis media, or respiratory tract infections or upper respiratory infections within 14 days of the study start.\n\nKnown hypersensitivity or allergy to any component of the probiotics or other study interventions.\n\nPhysical signs or symptoms suggestive of renal, hepatic, or cardiovascular disease.\n\nPregnant or lactating women.","ALL","18 Years","65 Years",{"count":64,"type":65},120,"ESTIMATED","INTERVENTIONAL",[68],"NA","The goal of this clinical trial is to learn if taking probiotics, vitamin D, or both together can help lower symptoms of allergic rhinitis (AR) and improve quality of life in adults. Allergic rhinitis is a condition that causes sneezing, nasal congestion, and itchy or watery eyes.\n\nThe main questions this study aims to answer are:\n\n• Do these supplements improve the quality of life for people with AR?\n\nResearchers will compare four groups:\n\n* People taking probiotics and vitamin D\n* People receiving standard treatment only (control group)\n\nParticipants will:\n\n* Take a probiotic capsule daily and\u002For a vitamin D tablet (based on blood levels) for 12 weeks\n* Continue standard allergic rhinitis treatment (like antihistamines or nasal sprays)\n* Visit the clinic for checkups and lab tests\n* Complete surveys about their symptoms and quality of life\n\nThis study will help researchers understand if adding probiotics and\u002For vitamin D to standard care can help people with allergic rhinitis feel better.",[71,72],"Allergic Rhinitis","Allergic Rhinitis (AR)",[74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,71],"Nutritional Supplementation","Integrative Medicine","Vitamin D Deficiency","T Regulatory Cells","Th2 Inflammation","Immune Response","Anti-inflammatory","Lactobacillus","Bifidobacterium","Gut Microbiota","Complementary Therapy","Combined Supplementation","Clinical Trial","Quality of Life","Nasal Symptoms","Immunomodulation","Vitamin D","Probiotics","2025-08-10",{"date":94,"type":95},"2025-08-14","ACTUAL",{"date":97,"type":95},"2025-08-01",{"date":99,"type":65},"2025-11-30",{"name":5,"class":6},1]