[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604993":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":20,"responsibleParty":27,"collaborators":20,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":37,"eligibilityCriteria":38,"healthyVolunteers":33,"sex":39,"minAge":40,"maxAge":41,"enrollmentInfo":42,"targetDuration":20,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":20,"overallStatus":51,"whyStopped":20,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":20},{"fullName":5,"class":6},"Schulthess Klinik","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Contralateral NMES","EXPERIMENTAL","Participants receive neuromuscular electrical stimulation (NMES) applied to the quadriceps muscle of the contralateral leg while performing voluntary quadriceps contractions on the injured side. Each participant completes two sessions: one after ACL injury and one after ACL reconstruction surgery.",[13],"Device: Neuromuscular Electrical Stimulation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Neuromuscular Electrical Stimulation","Studies in healthy individuals have demonstrated that NMES applied to the quadriceps of one limb induces short-term increases in strength and neural drive in the contralateral homologous muscle. Since these effects have only been observed in healthy individuals, it is essential to investigate whether similar responses occur in ACL patients.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Nicola Angelo Maffiuletti, PhD","CONTACT","+41 44 385 75 79","nicola.maffiuletti@kws.ch",{"type":28,"investigatorFullName":29,"investigatorTitle":30,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Nicola Maffiuletti","Head Research Group Human Performance Lab","100604993","effect-of-contralateral-nmes-on-quadriceps-activation-after-acl-injury-or-surgery-100604993",false,"NCT07156734","Effect of Contralateral NMES on Quadriceps Activation After ACL Injury or Surgery","Does NMES Applied to the Contralateral Uninjured Side Facilitate Voluntary Quadriceps Activation Before and After ACL Surgery?","ACLQuadAct","Inclusion Criteria:\n\n* Patients undergoing ACL surgery with semitendinosus tendon autograft in the Schulthess Clinic\n* Unilateral and primary ACL injury (with\u002Fwithout diagnoses of additional meniscus injury)\n\nExclusion Criteria:\n\n* Previous surgery\u002Fligament rupture in injured or uninjured knee or hip\n* Severe pain in the uninjured-side quadriceps or knee joint\n* Ongoing pregnancy\n* BMI \\>30 kg\u002Fm²\n* Neuromuscular disease\n* Open wounds or tissue injuries on the anterior aspect of the thigh\n* Additional rupture of other knee ligaments (posterior cruciate ligament, medial collateral ligament, lateral collateral ligament)\n* Implanted metallic\u002Felectronic devices (cardiac pacemakers, defibrillators)\n* Patients getting a femoralis block (peripheral nerve block) after surgery will be excluded for the post-surgical appointment\n* Insufficient language comprehension","ALL","18 Years","50 Years",{"count":43,"type":44},25,"ESTIMATED","INTERVENTIONAL",[47],"NA","A major complication after cruciate ligament injury and surgery is arthrogenic muscle inhibition of the quadriceps, which is characterised by a deficit in voluntary muscle activation in the affected leg. This can hinder rehabilitation processes, lead to impaired knee function, and negatively impact the patients' quality of life. The primary objective of this study is to assess whether voluntary quadriceps activation on the injured side is facilitated by the concomitant application of neuromuscular electrical stimulation (NMES) on the contralateral quadriceps.",[50],"ACL Injury","NOT_YET_RECRUITING","2025-08-27",{"date":54,"type":55},"2025-09-05","ACTUAL",{"date":57,"type":44},"2025-09",{"date":59,"type":44},"2026-09",{"name":5,"class":6}]