[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100470978":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":37,"centralContacts":51,"locations":58,"responsibleParty":75,"collaborators":37,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":37,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":37,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":104,"whyStopped":37,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"Medical University of Gdansk","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Supplemented population 300mg","PLACEBO_COMPARATOR","Supplemented population 300mg\u002F24h CoQ10 - 25 participants",[13],"Dietary Supplement: CoQ10 supplementation",{"label":15,"type":16,"description":17,"interventionNames":18},"Training and IPC preconditioning","EXPERIMENTAL","Group subjected to training and preconditioning by ischemia (IPC training) - 25 participants,",[19],"Procedure: Ischemic preconditioning training",{"label":21,"type":10,"description":22,"interventionNames":23},"Control group (placebo)","Control group to CoQ10 supplementation (placebo)- 25 participants",[24],"Dietary Supplement: Sham IPC combined with placebo",{"label":26,"type":27,"description":28,"interventionNames":29},"IPC control group","SHAM_COMPARATOR","IPC control group - 25 participants",[30],"Dietary Supplement: IPC training combined with CoQ10 supplementation",[32,38,43,47],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"DIETARY_SUPPLEMENT","CoQ10 supplementation","Young men training endurance running will be supplemented with CoQ10",[9],null,{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":37},"PROCEDURE","Ischemic preconditioning training","Young men training endurance running will undergo IPC training",[15],{"type":33,"name":44,"description":45,"armGroupLabels":46,"otherNames":37},"IPC training combined with CoQ10 supplementation","Young men training endurance running will undergo IPC training combined with CoQ10 supplementation",[26],{"type":33,"name":48,"description":49,"armGroupLabels":50,"otherNames":37},"Sham IPC combined with placebo","Young men training endurance running will undergo sham IPC training combined with placebo supplementation",[21],[52,57],{"name":53,"role":54,"phone":55,"phoneExt":37,"email":56},"Jedrzej Antosiewicz","CONTACT","0048 513046412","jant@gumed.edu.pl",{"name":53,"role":54,"phone":37,"phoneExt":37,"email":56},[59],{"facility":53,"status":37,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Gdansk","Pomeranian Voivodeship","80-210","Poland","PL",{"type":66,"coordinates":67},"Point",[68,69],18.64912,54.35227,{"lat":69,"lon":68},[72,74],{"name":73,"role":54,"phone":55,"phoneExt":37,"email":56},"Jedrzej Antosiewicz, Ph.D.",{"name":53,"role":54,"phone":37,"phoneExt":37,"email":56},{"type":76,"investigatorFullName":37,"investigatorTitle":37,"investigatorAffiliation":37,"oldNameTitle":37,"oldOrganization":37},"SPONSOR","100470978","effect-of-coq10-on-the-endocrine-function-of-skeletal-muscle-100470978",false,"NCT05412888","Effect of CoQ10 on the Endocrine Function of Skeletal Muscle","The Effect of Ischemic Preconditioning and Physical Exercise on the Endocrine Function of Skeletal Muscle - the Effect of CoQ10 Supplementation. In Vivo and in Vitro Studies.","Inclusion Criteria: - gender (males only),\n\n* not taking medication during the study,\n* good health (no concomitant injuries),\n* negative history of cardiovascular disorders, autonomic nervous system, mental disorders, cerebrospinal injuries and other diseases that may directly affect the results obtained.\n\nExclusion Criteria:\n\nLack of consent to participate in the research project or negative result of medical examinations.",true,"MALE","21 Years","29 Years",{"count":89,"type":90},100,"ESTIMATED","INTERVENTIONAL",[93],"NA","Recent studies have also shown that repeated episodes of ischemia, followed by reperfusion (IPC), can contribute to the development of adaptive changes not only in the area of the heart muscle, but also in the structure of the skeletal muscles.\n\nIn the project, several research questions will be evaluated e.g. what is the relationship between oxidative stress parameters, uric acid concentration and nitric oxide degradation products in groups of people undergoing two-week training in ischemic training, or what is the relationship between the expression of genes associated with muscle cell growth (e.g. myostatin gene) and the effect of ischemia preconditioning training etc.",[96,97,98],"Ischemic Preconditioning","Coenzyme Q Deficiency","Exercise Training",[100,101,102,103],"skeletal muscle","myokines","ischemia","inflammation","NOT_YET_RECRUITING","2023-01-02",{"date":107,"type":108},"2023-01-04","ACTUAL",{"date":110,"type":90},"2023-03-01",{"date":112,"type":90},"2026-09-30",{"name":5,"class":6},1]