[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599331":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":12,"centralContacts":29,"locations":39,"responsibleParty":60,"collaborators":12,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":62,"acronym":12,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":12,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":12,"overallStatus":83,"whyStopped":12,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Pakistan Institute of Medical Sciences","OTHER_GOV",[8,13,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: Control group","NO_INTERVENTION","Same tooth on the contra lateral side",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Group B: Full-coverage PFM crowns","EXPERIMENTAL","Microbial analysis will be carried out around the PFM crowns",[18],"Other: Experimental",{"label":20,"type":15,"description":21,"interventionNames":22},"Group C: Full-coverage Zirconia crowns","Microbial analysis will be carried out around the Full-coverage Zirconia crowns",[18],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":12},"OTHER","Experimental","* Eligible participants will be randomly assigned to one of the following groups using a computer-generated sequence with allocation concealment via sealed opaque envelopes:\n\n  * Group A: Control group\n  * Group B: Full-coverage PFM crowns\n  * Group C: Full-coverage Zirconia crowns\n* Baseline gingival samples will be collected with the help of sterile swab from the target tooth region prior to prosthesis placement and at the follow-up visits i.e. 1, and 3 months; both for experimental groups and control group.\n* Microbial analysis will be conducted through culture techniques to quantify CFUs and identify species.\n* Alongside, the same sample from sterile swabs will be smeared by fixating it on a microscopic slide and then Candida albicans will be stained by Periodic Acid Schiff technique, and the bacterial species using Gram staining.",[14,20],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":12,"email":34},"Fatima Nasir Cheema, BDS, Post graduate Resident","CONTACT","+923227965188","fatimanasir969@gmail.com",{"name":36,"role":32,"phone":37,"phoneExt":12,"email":38},"Maria Shakoor Abbasi, BDS, FCPS","+923333615061","maria_shakoor@hotmail.com",[40],{"facility":41,"status":12,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"School of Dentistry, SZAMBU","Islamabad","Federal","44000","Pakistan","PK",{"type":48,"coordinates":49},"Point",[50,51],73.04329,33.72148,{"lat":51,"lon":50},[54,57,58],{"name":55,"role":32,"phone":56,"phoneExt":12,"email":34},"Fatima Nasir Cheema, BDS, Post graduate resident","03227965188",{"name":36,"role":32,"phone":37,"phoneExt":12,"email":38},{"name":55,"role":59,"phone":12,"phoneExt":12,"email":12},"PRINCIPAL_INVESTIGATOR",{"type":59,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Fatima Nasir Cheema","Effect of Crown Material on Gingival Microbial Colonization: A Randomized Clinical Trial","100599331","effect-of-crown-material-on-gingival-microbial-colonization-100599331",false,"NCT07083102","Effect of Crown Material on Gingival Microbial Colonization","Inclusion Criteria:\n\n* Age between 20 to 50 years.\n* Both male and female patients will be selected.\n* Good oral hygiene (Defined as a plaque index score ≤ 1 across all assessed surfaces and no visible calculus deposits)\n* Dentate patients require fixed prostheses for the first time on mandibular pre-molars and molars.\n* Patient with no history of any dental and bony pathosis (cysts, cancerous lesion).\n\nExclusion Criteria:\n\n* Untreated periodontal diseases\n* Xerostomia\n* Pregnancy, lactation\n* Smokers\n* Individuals with systemic conditions like diabetes and immunosuppressive diseases",true,"ALL","20 Years","50 Years",{"count":74,"type":75},30,"ESTIMATED","INTERVENTIONAL",[78],"NA","* Prior approval from SOD ethical committee has been received.\n* All patients presenting to the General OPD of School of Dentistry, Islamabad will be screened. Those patients who fulfill the criteria will be referred to the Prosthodontics department.\n* The patients will undergo detailed history and oral examination after informed consent (Annexure-A). Patients will undergo radiographic investigation and based on this information they will be selected for the study according to the exclusion and inclusion criteria.\n* Eligible participants will be randomly assigned to one of the following groups using a computer-generated sequence with allocation concealment via sealed opaque envelopes:\n\n  * Group A: Control group\n  * Group B: Full-coverage PFM crowns\n  * Group C: Full-coverage Zirconia crowns\n* Baseline gingival samples will be collected with the help of sterile swab from the target tooth region prior to prosthesis placement and at the follow-up visits i.e. 1, and 3 months; both for experimental groups and control group.\n* Microbial analysis will be conducted through culture techniques to quantify CFUs and identify species.\n* A summary of the micro-organisms, their incubation media, temperature and time is presented in the following table:\n\nTable 1: Summary of the micro-organisms, their incubation media, temperature and time Micro-organism Growth Media Temperature Incubation time Candida albicans Saboraud Agar 370C 24-48 hours Streptococcus mutans BHI broth 370C 24-48 hours Staphylococcus aureus BHI broth 370C 24-48 hours Porphyromonas gingivalis BHI broth 370C 18-24 hours\n\n* Alongside, the same sample from sterile swabs will be smeared by fixating it on a microscopic slide and then Candida albicans will be stained by Periodic Acid Schiff technique, and the bacterial species using Gram staining.\n* All participants will receive standardized verbal and written instructions oral hygiene instructions to control for hygiene-related variation",[81,82],"Microbial Colonization","Missing Teeth","NOT_YET_RECRUITING","2025-07-16",{"date":86,"type":87},"2025-07-24","ACTUAL",{"date":89,"type":75},"2025-08-15",{"date":91,"type":75},"2025-12-15",{"name":5,"class":6},1]