[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634386":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":36,"responsibleParty":106,"collaborators":11,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":110,"sex":115,"minAge":116,"maxAge":11,"enrollmentInfo":117,"targetDuration":11,"studyType":120,"phases":121,"briefSummary":123,"conditions":124,"keywords":126,"overallStatus":39,"whyStopped":11,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":133,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Saint Etienne","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Group","EXPERIMENTAL",null,[13],"Procedure: Fuchs Polishing",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"PROCEDURE","Fuchs Polishing","he study will be offered to all patients for whom corneal transplantation for FECD is indicated at participating centers. After verification of the eligibility criteria, the study will be explained and informed consent will be obtained during the inclusion visit. Only one follow-up visit is planned, on the day of surgery. During the procedure, polishing of one half of the pathological endothelium will be performed prior to its removal and replacement with healthy donor endothelium (Fuchs polishing). The excised pathological endothelium will be sent to the laboratory for analysis.",[9],[21],{"name":22,"affiliation":23,"role":24},"Gilles THURET, MD-PhD","Centre Hospitalo-Universitaire de Saint-Etienne","PRINCIPAL_INVESTIGATOR",[26,32],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Gilles THURET, MD PhD","CONTACT","(0)4 77 12 77 96","+33","gilles.thuret@univ-st-etienne.fr",{"name":33,"role":28,"phone":34,"phoneExt":30,"email":35},"Clara Pfenninger, PhD","(0)4 77 12 02 87","clara.pfenninger@chu-st-etienne.fr",[37,52,67,81,92],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":41,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"CHU de Saint-Etienne","RECRUITING","Saint-Etienne","France","42055","FR",{"type":45,"coordinates":46},"Point",[47,48],4.39,45.43389,{"lat":48,"lon":47},[51],{"name":22,"role":28,"phone":29,"phoneExt":30,"email":31},{"facility":53,"status":54,"city":55,"state":55,"zip":56,"country":41,"countryCode":43,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"Hopital de Mercy","NOT_YET_RECRUITING","Metz","57085",{"type":45,"coordinates":58},[59,60],6.17269,49.11911,{"lat":60,"lon":59},[63],{"name":64,"role":28,"phone":65,"phoneExt":30,"email":66},"Jean-Marc Perone, MD","(0)387553426","jean-marc.perone@chr-metz-thionville.fr",{"facility":68,"status":54,"city":69,"state":69,"zip":70,"country":41,"countryCode":43,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Cochin Hospital","Paris","75014",{"type":45,"coordinates":72},[73,74],2.3488,48.85341,{"lat":74,"lon":73},[77],{"name":78,"role":28,"phone":79,"phoneExt":30,"email":80},"Jean-Louis Bourges, MD-PhD","(0)1 58 41 22 20","jean-louis.bourges@aphp.fr",{"facility":82,"status":54,"city":69,"state":69,"zip":83,"country":41,"countryCode":43,"cosmosGeoPoint":84,"geoPoint":86,"contacts":87},"Hôpital Fondation Rothschild","75019",{"type":45,"coordinates":85},[73,74],{"lat":74,"lon":73},[88],{"name":89,"role":28,"phone":90,"phoneExt":30,"email":91},"Damien Guindolet, MD PhD","(0)6 77 84 77","dguindolet@for.paris",{"facility":93,"status":54,"city":94,"state":94,"zip":95,"country":41,"countryCode":43,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Centre Hospitalier Universitaire de Rouen","Rouen","76000",{"type":45,"coordinates":97},[98,99],1.09932,49.44313,{"lat":99,"lon":98},[102],{"name":103,"role":28,"phone":104,"phoneExt":30,"email":105},"Marc Muraine, MD-PhD","(0)2 32 88 80 57","muraine@free.fr",{"type":107,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100634386","effect-of-descemet-membrane-polishing-in-fuchs-endothelial-corneal-dystrophy-100634386",false,"NCT07539012","Effect of Descemet Membrane Polishing in Fuchs Endothelial Corneal Dystrophy","Fuchs Polishin","Inclusion Criteria:\n\n* Patient affiliated with or entitled to a social security scheme\n* Patient scheduled for endothelial keratoplasty for Fuchs endothelial corneal dystrophy\n* Patient having received full information and having provided written informed consent\n\nExclusion Criteria:\n\n* Pregnant women\n* Adults under legal protection (guardianship\u002Fcuratorship) or unable to provide informed consent","ALL","18 Years",{"count":118,"type":119},20,"ESTIMATED","INTERVENTIONAL",[122],"NA","Fuchs endothelial corneal dystrophy (FECD) is the leading indication for corneal transplantation worldwide. It is characterized by the accumulation of guttae and progressive loss of corneal endothelial cells, leading to corneal edema and visual impairment. Endothelial keratoplasty remains the standard treatment; however, graft shortages have driven the development of cell-based therapies involving the injection of cultured endothelial cells. A key unresolved issue is whether removal of the pathological endothelium prior to injection improves cell adhesion. Clinical data are limited and sometimes contradictory, particularly regarding endothelial polishing. The actual effectiveness of this procedure in removing guttae and enhancing the survival of injected cells remains uncertain. Therefore, an in vivo clinical evaluation is required to assess its impact on guttae removal.",[125],"Fuchs Endothelial Corneal Dystrophy",[125,127,128],"Corneal endothelial polishing","Ophtalmic therapeutics","2026-05-21",{"date":131,"type":132},"2026-05-26","ACTUAL",{"date":129,"type":132},{"date":135,"type":119},"2027-03-01",{"name":5,"class":6},5]