[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544530":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":32,"locations":43,"responsibleParty":65,"collaborators":37,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":37,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":37,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":37,"overallStatus":46,"whyStopped":37,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Egymedicalpedia","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Human Albumin Group","EXPERIMENTAL","About 23 patients will be objected for resuscitation with 60 gm (300 ml) human albumin 20% (HA 20%) over 2-3 hours combined usual practice with 30 ml\u002Fkg crystalloid.",[13],"Drug: Albumin Human",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","ACTIVE_COMPARATOR","About 23 patients will be objected for resuscitation with 30 ml\u002Fkg crystalloid.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Albumin Human","To investigate the effect of early administration of albumin in the ICU after onset of septic shock compared to volume replacement therapy without albumin on patient outcome.",[15,9],[26],"crystalloids",[28],{"name":29,"affiliation":30,"role":31},"Mohamed Ahmed Mohamed, Professor","ICU department , Faculty of Medicine, Assuit University","STUDY_CHAIR",[33,39],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Ahmed Abdelhamed Helal, MSC","CONTACT","+201140415513",null,"Ahmedel3oksh@gmail.com",{"name":40,"role":35,"phone":41,"phoneExt":37,"email":42},"Noha Yahia Mohamed, Lecturer","+201001890194","Noha.hgagy@gmail.com",[44],{"facility":45,"status":46,"city":47,"state":37,"zip":37,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Assuit University hospitals","RECRUITING","Asyut","Egypt","EG",{"type":51,"coordinates":52},"Point",[53,54],31.18368,27.18096,{"lat":54,"lon":53},[57,59,63],{"name":58,"role":35,"phone":36,"phoneExt":37,"email":38},"Ahmed Abdelhamed Helal Mohamed, MSc",{"name":60,"role":35,"phone":61,"phoneExt":37,"email":62},"Amany Hassan Abdelwahab, Assist.Prof.","+201004610623","Amanihassan1976@yahoo.com",{"name":40,"role":64,"phone":37,"phoneExt":37,"email":37},"PRINCIPAL_INVESTIGATOR",{"type":66,"investigatorFullName":37,"investigatorTitle":37,"investigatorAffiliation":37,"oldNameTitle":37,"oldOrganization":37},"SPONSOR","100544530","effect-of-early-administration-of-albumin-20-versus-crystalloid-100544530",false,"NCT06370078","Effect of Early Administration of Albumin 20% Versus Crystalloid","Effect of Early Administration of Albumin 20% Versus Crystalloid During Resuscitation of Patient With Septic Shock: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Presence of septic shock that meets all the following Criteria: Clinically possible, probable, or microbiologically confirmed infection according to the definitions of the International-Sepsis- Forums (ISF), Despite adequate volume therapy, vasopressors are required to maintain mean arterial pressure (MAP) ≥ 65 mmHg for at least 1 hour, Serum lactate concentration \\> 2 mmol\u002Fl (18 mg\u002Fdl) despite adequate volume therapy.\n* Onset of septic shock less than 24 h prior to study inclusion.\n* Women of childbearing age: negative pregnancy test\n\nExclusion Criteria:\n\n* Moribund conditions\n* End of life decisions\n* Previous participation to this trial or any other interventional clinical trial\n* Known hypersensitivity to albumin or any component of the trial drug\n* Clinical conditions, where albumin administration may be unfavourable\n* Breast feeding","ALL","18 Years","60 Years",{"count":78,"type":79},46,"ESTIMATED","INTERVENTIONAL",[82],"NA","Sepsis and septic shock are global health problems, leading to a high mortality rate. They are often associated with extremely low blood pressure and multiple organ dysfunctions, which are the main causes of death in critically ill patients. Fluid resuscitation is one of the most critical treatments for patients with sepsis and septic shock.\n\nAn early administration of an appropriate fluid to patients is considered the most effective way to increase blood pressure, improve tissue perfusion, and save their lives. Crystalloid fluids are a subset of intravenous solutions composed of mineral salts and other small, water-soluble molecules, including normal, isotonic or hypertonic saline, and various buffered solutions.",[85],"Septic Shock","2024-06-04",{"date":88,"type":89},"2024-06-06","ACTUAL",{"date":91,"type":89},"2024-06-01",{"date":93,"type":79},"2024-11-30",{"name":5,"class":6},1]