[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633899":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":11,"centralContacts":39,"locations":45,"responsibleParty":59,"collaborators":11,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":11,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":11,"enrollmentInfo":72,"targetDuration":11,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":85,"whyStopped":11,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Erasme University Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"ICNB before incision","EXPERIMENTAL",null,[13,14],"Procedure: Intercostal nerve block before (ropivacaine 0.375%)","Procedure: ICNB after (physiological serum)",{"label":16,"type":17,"description":11,"interventionNames":18},"ICNB at the end of surgery","ACTIVE_COMPARATOR",[19,20],"Procedure: Intercostal Nerve Bloc before (physiological serum)","Procedure: ICNB after (ropivacaine 0.375%)",[22,27,31,35],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":11},"PROCEDURE","Intercostal nerve block before (ropivacaine 0.375%)","All patients will receive two intercostal nerve blocks using the same injection volume and technique. Intercostal nerve blocks will be performed twice: before surgical incision and at the end of the procedure.\n\nIn both study groups, one injection will contain ropivacaine 0.375% and the other will contain normal saline. In the interventional arm, the pre-incision intercostal nerve block will contain the local anesthetic, whereas the end-of-procedure intercostal nerve block will contain normal saline. In the comparator arm, the pre-incision intercostal nerve block will contain normal saline, whereas the end-of-procedure intercostal nerve block will contain the local anesthetic.",[9],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":11},"Intercostal Nerve Bloc before (physiological serum)","All patients will receive intercostal nerve blocks using the same local anesthetic (ropivacaine 0.375%). Intercostal nerve blocks will be performed twice: before surgical incision and at the end of the procedure.\n\nIn the interventional arm, the pre-incision intercostal nerve block will contain the local anesthetic, whereas the end-of-procedure intercostal nerve block will contain normal saline. In the comparator arm, the pre-incision intercostal nerve block will contain normal saline, whereas the end-of-procedure intercostal nerve block will contain the local anesthetic.",[16],{"type":23,"name":32,"description":33,"armGroupLabels":34,"otherNames":11},"ICNB after (ropivacaine 0.375%)","All patients will receive intercostal nerve blocks using the same local anesthetic (ropivacaine 0.375%). Intercostal nerve blocks will be performed twice: before surgical incision and at the end of the procedure. In the interventional arm, the pre-incision intercostal nerve block will contain the local anesthetic, and the end-of-procedure intercostal nerve block will contain normal saline. In the comparator arm, the pre-incision intercostal nerve block will contain normal saline, and the end-of-procedure intercostal nerve block will contain the local anesthetic.",[16],{"type":23,"name":36,"description":37,"armGroupLabels":38,"otherNames":11},"ICNB after (physiological serum)","All patients will receive an intercostal nerve block using the same local anesthetic (ropivacaine 0.375%). ICNB will be performed twice: before surgical incision and at the end of the procedure. In the interventional arm, the ICNB before surgery will contain the local anesthetic, and the ICNB after surgery will contain normal saline. In the comparator arm, the ICNB before surgery will contain normal saline, and the ICNB after surgery will contain the local anesthetic.",[9],[40],{"name":41,"role":42,"phone":43,"phoneExt":11,"email":44},"Celine Boudart","CONTACT","+3225553919","celine.boudart@hubruxelles.be",[46],{"facility":47,"status":11,"city":48,"state":11,"zip":11,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"HUB Erasme","Brussels","Belgium","BE",{"type":52,"coordinates":53},"Point",[54,55],4.34878,50.85045,{"lat":55,"lon":54},[58],{"name":41,"role":42,"phone":43,"phoneExt":11,"email":44},{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Céline Boudart","MD PhD","100633899","effect-of-early-versus-late-surgical-intercostal-block-on-postoperative-pain-relief-following-video-assisted-thoracic-surgery-vats-100633899",false,"NCT07532681","Effect of Early Versus Late Surgical Intercostal Block on Postoperative Pain Relief Following Video-Assisted Thoracic Surgery (VATS)","Effect of Early Versus Late Surgical Intercostal Block on Postoperative Pain Relief Following Video-Assisted Thoracic Surgery (VATS): a Randomised, Double-blind Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Scheduled for single-port or two-port video-assisted thoracoscopic surgery (VATS).\n* ASA classification 1 to 3\n* Able to understand the study, describe their pain and provide valid informed consent\n\nExclusion Criteria:\n\n* Neurological or psychiatric conditions that compromise the reliable assessment of pain(dementia, cognitive impairment, severe communication disorders)\n* Chronic opioid use or regular use (\\> 3 months) of strong analgesics for chronic pain\n* History of allergy or known hypersensitivity to local anaesthetics\n* Coagulopathy or anticoagulant therapy precluding the safe performance of an intercostal block\n* Local infection at the injection site or active systemic infection\n* Bilateral thoracic surgery or intraoperative conversion to thoracotomy\n* Second surgery at the same site.\n* Current pregnancy or breastfeeding\n* Inability to understand postoperative instructions or a language barrier preventing a validated assessment of pain\n* Simultaneous participation in another clinical trial involving analgesia or thoracic surgery\n* Refusal to participate or withdrawal of consent at any time","ALL","18 Years",{"count":73,"type":74},140,"ESTIMATED","INTERVENTIONAL",[77],"NA","Video-assisted thoracoscopic surgery (VATS) is associated with significant postoperative pain despite lower morbidity compared with thoracotomy. Adequate pain management is essential within Enhanced Recovery After Surgery (ERAS) pathways to preserve respiratory function and facilitate postoperative recovery. Surgical intercostal block performed under direct vision is a simple and effective regional analgesic technique commonly used following VATS. However, the optimal timing of intercostal block administration during surgery remains uncertain.\n\nThis prospective randomized double-blind study will compare surgical intercostal block performed at the beginning versus the end of the surgical procedure. The study aims to evaluate the effect of block timing on postoperative pain intensity and postoperative opioid consumption. The results may help optimize multimodal analgesic strategies in patients undergoing thoracic surgery.",[80,81],"Video Assisted Thoracic Surgery (VATS)","Intercostal Nerve Block",[83,81,84],"VATS","Pain","NOT_YET_RECRUITING","2026-04-09",{"date":88,"type":89},"2026-04-16","ACTUAL",{"date":91,"type":74},"2026-04-01",{"date":93,"type":74},"2027-09-30",{"name":5,"class":6},1]