[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592211":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":31,"responsibleParty":75,"collaborators":18,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":18,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":18,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":18,"overallStatus":63,"whyStopped":18,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Southeast University, China","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"EIT-guided PEEP group","EXPERIMENTAL","Patients will receive PEEP titrated by EIT with a stepwise decrease PEEP trial",[13],"Device: EIT-guided PEEP",{"label":15,"type":16,"description":17,"interventionNames":18},"low PEEP-FiO2 table group","NO_INTERVENTION","PEEP will be set according to the low FiO2-PEEP table to keep the oxygenation goals: SpO2 between 90% and 96%, and PaO2 between 60mmHg and 90mmHg.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DEVICE","EIT-guided PEEP","PEEP titrated by EIT will be performed with a decremental trial at the enrollment. Right after completing RM, PEEP will be set to 20cmH2O or to 24cmH2O and then reduced in steps of 2cmH2O from 20 to 4 every 30s.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"yuan xue yan, MD, MD","CONTACT","+86 83262550","18826401594@163.com",[32,51,61],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Department of Critical Care Medicine, Zhongshan Hospital of Fudan University","NOT_YET_RECRUITING","Shanghai","China Mainland","200000","China","CN",{"type":41,"coordinates":42},"Point",[43,44],121.45806,31.22222,{"lat":44,"lon":43},[47],{"name":48,"role":28,"phone":49,"phoneExt":18,"email":50},"zhong ming PhD, PhD","021-64373564","2324858754@qq.com",{"facility":52,"status":34,"city":35,"state":36,"zip":53,"country":38,"countryCode":39,"cosmosGeoPoint":54,"geoPoint":56,"contacts":57},"Department of Critical Care Medicine, Renji Hospital","20000",{"type":41,"coordinates":55},[43,44],{"lat":44,"lon":43},[58],{"name":59,"role":28,"phone":60,"phoneExt":18,"email":50},"li zhe Li Zhe, PhD","021-68383354",{"facility":62,"status":63,"city":64,"state":65,"zip":66,"country":38,"countryCode":39,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Zhongda Hospital, School of Medicine, Southeast University","RECRUITING","Nanjing","Jiangsu","210009",{"type":41,"coordinates":68},[69,70],118.77778,32.06167,{"lat":70,"lon":69},[73],{"name":74,"role":28,"phone":29,"phoneExt":18,"email":30},"yuan xueyan, MD",{"type":76,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Ling Liu","pH.D","100592211","effect-of-eit-guided-peep-in-ards-patients-100592211",false,"NCT06990477","Effect of EIT-guided PEEP in ARDS Patients","Effect of EIT-guided PEEP On Clinical Outcomes in ARDS Patients: a Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age≥18 years\n2. Moderate-to-severe ARDS, defined by the ARDS Definition Task Force in the Berlin definition (partial pressure of arterial oxygen \\[PaO2\\]:FiO2 ratio ≤200 mmHg with a PEEP ≥5 cmH2O)\n3. Diagnosis of ARDS less than 72 hours\n\nExclusion Criteria:\n\n1. Expected to be mechanically ventilated for less than 48 hours\n2. Severe chronic respiratory diseases requiring long-term home oxygen therapy or noninvasive MV\n3. Undrained pneumothorax or subcutaneous emphysema\n4. Contraindication to the use of EIT (pacemaker, automatic implantable cardioverter defibrillator, and implantable pumps)\n5. Severe neuromuscular disease\n6. Hemodynamic instability\n7. Contraindications to hypercapnia, such as intracranial hypertension or acute coronary syndrome\n8. Severe other organs dysfunction with a low expected survival (7 days) or palliative care\n9. Solid organ or hematologic tumors with the expected survival time less than 30 days\n10. Participating in other clinical trials within 30 days\n11. Pregnancy\n12. Refusal to sign the informed consent","ALL","19 Years","90 Years",{"count":90,"type":91},2400,"ESTIMATED","INTERVENTIONAL",[94],"NA","Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, the PEEP selection is still a difficult problem for moderate to severe ARDS patients. EIT, an imaging tool evaluating the regional ventilation distribution at the bedside, can achieve the individual PEEP selection for all mechanically ventilated patients. Our previous study found that moderate to severe ARDS patients with higher recruitability could benefit from EIT-guided PEEP. This article compared the effect of PEEP titrated guided by EIT with fraction of inspired oxygen (FiO2)-PEEP table on the clinical outcomes in ARDS patients.",[97],"ARDS (Acute Respiratory Distress Syndrome)","2026-05-19",{"date":100,"type":101},"2026-05-22","ACTUAL",{"date":103,"type":91},"2026-05-13",{"date":105,"type":91},"2029-02-20",{"name":5,"class":6},3]