[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622407":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":37,"locations":43,"responsibleParty":58,"collaborators":27,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":27,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":27,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":88,"overallStatus":46,"whyStopped":27,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Cairo University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Combined TENS and Isometric Exercise","EXPERIMENTAL","Participants in this arm will receive a combined intervention of Transcutaneous Electrical Nerve Stimulation (TENS) and a structured protocol of isometric exercises specifically designed for patients with resistant hypertension.",[13,14],"Device: Transcutaneous Electrical Nerve Stimulation","Behavioral: Isometric Exercise",{"label":16,"type":17,"description":18,"interventionNames":19},"Conventional Physical Therapy Program","ACTIVE_COMPARATOR","Participants in this arm will receive a standard conventional physical therapy program. This serves as the active control to compare the effectiveness of the combined TENS and exercise protocol against current standard practice.",[20],"Behavioral: Aerobic, Dynamic Resistance, stretch and Breathing Exercises and Lifestyle Modification Advices",[22,28,33],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DEVICE","Transcutaneous Electrical Nerve Stimulation","Application of TENS Electrode placements: bilaterally over the Paraspinal muscles at the T1-T5 levels (upper thoracic region), targeting sympathetic outflow to the cardiovascular system.\n\nFrequency: 2-10 Hz (low frequency stimulation) Pulse duration: 200 microseconds Intensity: strong but comfortable tingling sensations, below motor threshold (typically between 10-20mA) Session duration: 30 minutes per session Session frequency: 3 times per week Total intervention duration: 8 weeks",[9],null,{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":27},"BEHAVIORAL","Isometric Exercise","Device: Hand grip dynamometer. protocol:\n\n* 30% of the participants' maximal voluntary contraction (MVC).\n* Duration per trial: 2 minutes.\n* Number of trials per session: 4 repetitions\n* Rest interval between trials: 1 minute\n* Session frequency: 3 sessions per week\n* Total session duration: 14 minutes\n\nPer session:\n\n* 4 sets × 2 minutes = 8 minutes of active contraction\n* Rest between sets: 1 to 3 minutes (average 2 min × 3 rests = 6 minutes)\n* So total session time: average 14 minutes. • Total intervention duration: 8 weeks",[9],{"type":29,"name":34,"description":35,"armGroupLabels":36,"otherNames":27},"Aerobic, Dynamic Resistance, stretch and Breathing Exercises and Lifestyle Modification Advices","1. Aerobic exercise: moderate (brisk walking): 30 min, 5 times per week.\n2. Engage in dynamic resistance exercise (weight training): 2 or more days non-consecutive.\n3. Minimize sedentary behavior\n4. Maintain healthy weight\n5. Nutritional advice like:\n\n   * Eat at least 5 portions of fruit and vegetables\n   * Eat more lean protein e.g. Fish and nuts\n   * Eat less salt \\\u003C5g or 1tsp\n   * Eat 25-29 g of fiber\n   * Limit alcohol\n   * Drink 2-3 cups of coffee and\u002For tea (unsweetened)\n6. Others:\n\n   * Sleep: 7-9h\u002Fday\n   * Reduce stress: practice meditation or yoga 30 min per day\n   * Listen to music at least 25 min, 3 times per week\n   * Stop smoking\n   * Limit pollutions exposure\n   * Use digital wearables\u002Fapps to track movement\n7. Breathing exercise:\n\n   Slow breathing at a rate of 6 breath\u002Fmin for 10 minutes.\n8. Stretching exercise:\n\nStatic stretching exercise is mainly for large bulky muscles 30 sec stretch, 30 sec rest for 5 min",[16],[38],{"name":39,"role":40,"phone":41,"phoneExt":27,"email":42},"Mohamed Mohamed Morgan, Bachelor of Physical Therapy","CONTACT","201026099152","m.morgan@cu.edu.eg",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":27},"Out Clinics of Port Said Hospitals","RECRUITING","Port Said","Port Said Governorate","42515","Egypt","EG",{"type":53,"coordinates":54},"Point",[55,56],32.3019,31.26531,{"lat":56,"lon":55},{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"SPONSOR_INVESTIGATOR","Mohamed Mohamed Ali Morgan","Demonstrator of Physical Therapy","100622407","effect-of-electrical-stimulation-and-exercise-on-blood-flow-in-patients-with-resistant-high-blood-pressure-100622407",false,"NCT07383220","Effect of Electrical Stimulation and Exercise on Blood Flow in Patients With Resistant High Blood Pressure","Effect of Combined Transcutaneous Electrical Stimulation and Isometric Exercise on Peripheral Hemodynamic Parameters in Patients With Resistant Hypertension","Inclusion Criteria:\n\n* Age between 50 and 60 years. Both sexes were included Patients had been diagnosed with hypertension for at least 5 years.\n\nPatients had resistant hypertension according to (Whelton et al 2018), defined as:\n\n* Systolic blood pressure (SBP) ≥140 mmHg and\u002For diastolic blood pressure (DBP) ≥90 mmHg despite the use of three or more antihypertensive medications of different classes, including a diuretic,\n* or controlled blood pressure (\\\u003C140\u002F90 mmHg) while on four or more antihypertensive medications.\n\nBody Mass Index (BMI) 25: 34.9 kg\u002Fm²\n\nIncreased waist circumference, defined as:\n\n* Greater than 102 cm for males.\n* Greater than 88 cm for females.\n\nExclusion Criteria:\n\n* Secondary hypertension due to identifiable causes (e.g., renal artery stenosis, primary aldosteronism, pheochromocytoma).\n* History of major cardiovascular events in the last 6 months (e.g., myocardial infarction, stroke, or heart failure exacerbation).\n* Severe musculoskeletal or neurological disorders that impair the ability to perform isometric exercise safely (e.g., recent joint replacement, severe osteoarthritis, stroke with residual motor deficit).\n* Contraindications to the use of Transcutaneous Electrical Nerve Stimulation (TENS):\n\nImplanted electronic devices: pacemakers, cardioverter defibrillators. Uncontrolled arrhythmias. Sever skin condition: open wounds, rashes, burns, eczema. Peripheral neuropathy or sensory loss.\n\n-Known cognitive impairment or psychiatric conditions that would limit the ability to follow instructions or provide informed consent.","ALL","50 Years","60 Years",{"count":73,"type":74},50,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this clinical trial is to learn if the combination between transcutaneous electrical nerve stimulation (TENS) and isometric exercise (IE) can improve blood pressure in men and women between 50 to 60 years old suffered from resistant hypertension which is a type of hypertension where blood pressure remains above your target goal despite the use of three or more different classes of antihypertensive medications at their maximum tolerated doses. The main question to answer is:\n\nIs there a significant effect on the combined use of TENS and IE on peripheral hemodynamic parameters in patients with resistant hypertension? Total sample will be 50 patients from both sexes\n\nI will compare between two groups:\n\nExperimental group (15 men, 10 women) will take: medication plus IE and TENS Control group (15 men, 10 women) will take: medication plus Conventional Physical Therapy Program",[80,81,82,83,84,85,86,87],"Resistant Hypertension","Hemodynamic Instability","Essential (Primary) Hypertension","Abdominal Obesity","Metabolic Syndrome","Hypertension (HTN)","Vascular Resistance","High Blood Pressure",[89,90,91,92,93,94,95,96],"Mean Arterial Pressure","Peripheral Hemodynamics","Physical Therapy","Long Term Hypertension","Resistant HTN","Systolic Blood Pressure (SBP)","Diastolic Blood Pressure (DBP)","Heart Rate Variability (HRV)","2026-01-28",{"date":99,"type":100},"2026-02-03","ACTUAL",{"date":102,"type":74},"2026-01-15",{"date":104,"type":74},"2026-06-10",{"name":60,"class":6},1]