[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632100":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":35,"centralContacts":40,"locations":49,"responsibleParty":65,"collaborators":24,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":24,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":96,"whyStopped":24,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"University of Zagreb","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Electroacupuncture Group","EXPERIMENTAL","Participants receive electroacupuncture for 15 minutes prior to administration of local anesthesia, according to a standardized protocol involving selected local and distal acupuncture points. Electrical stimulation is applied using a digital electroacupuncture device at an individually adjusted intensity sufficient to produce a clear sensation without pain or discomfort. Following the intervention, participants undergo standard surgical extraction of the impacted lower third molar under local anesthesia.",[13],"Procedure: Electroacupuncture",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Acupuncture Group","SHAM_COMPARATOR","Participants receive a sham acupuncture procedure for 15 minutes prior to administration of local anesthesia. This involves superficial needle insertion at non-acupuncture points without electrical stimulation or needle manipulation, mimicking the procedural aspects of electroacupuncture without therapeutic effect. The duration and conditions are identical to the electroacupuncture group. After the procedure, participants undergo standard surgical extraction under local anesthesia.",[19],"Procedure: Sham Acupuncture",{"label":21,"type":22,"description":23,"interventionNames":24},"Control Group","NO_INTERVENTION","Participants receive standard care consisting of local anesthesia and surgical extraction of the impacted lower third molar without any acupuncture intervention. All other aspects of perioperative management are consistent with routine clinical practice.",null,[26,31],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":24},"PROCEDURE","Electroacupuncture","Electroacupuncture is applied for 15 minutes prior to local anesthesia using a standardized protocol with selected acupuncture points. Electrical stimulation is delivered via a digital electroacupuncture device at an individually adjusted intensity to produce a clear but non-painful sensation.",[9],{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":24},"Sham Acupuncture","Sham acupuncture consists of superficial needle insertion at non-acupuncture points without electrical stimulation or needle manipulation. The procedure mimics the active intervention in duration and setting but is designed to have no therapeutic effect.",[15],[36],{"name":37,"affiliation":38,"role":39},"Jasminka Peršec, Associate Professor, PhD","University Hospital Dubrava","STUDY_CHAIR",[41,46],{"name":42,"role":43,"phone":44,"phoneExt":24,"email":45},"Ivan Salaric, Associate Professor, PhD","CONTACT","003851290 2444","salaric@sfzg.unizg.hr",{"name":47,"role":43,"phone":24,"phoneExt":24,"email":48},"Monika Ilić, MD","monika.seric.ilic@gmail.com",[50],{"facility":38,"status":24,"city":51,"state":24,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Zagreb","10000","Croatia","HR",{"type":56,"coordinates":57},"Point",[58,59],15.97798,45.81444,{"lat":59,"lon":58},[62],{"name":63,"role":43,"phone":64,"phoneExt":24,"email":45},"Ivan Salaric","003851 2902 444",{"type":66,"investigatorFullName":63,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Associate Professor, PhD","100632100","effect-of-electroacupuncture-with-local-anesthesia-on-pain-and-stress-during-impacted-lower-third-molar-surgery-100632100",false,"NCT07509294","Effect Of Electroacupuncture With Local Anesthesia On Pain And Stress During Impacted Lower Third Molar Surgery","Effect Of Electroacupuncture As An Adjunct To Local Anesthesia On Perioperative Pain And Stress During Ambulatory Surgical Extraction Of Impacted Lower Third Molars","EASE","Inclusion Criteria:\n\n* Adults aged 25-35 years\n* ASA physical status I-II\n* Indication for ambulatory surgical extraction of an impacted lower third molar\n* Ability to understand the study procedures and provide written informed consent\n* Willingness to comply with study procedures, including saliva sampling protocol\n* Ability to abstain from food, beverages, and oral hygiene procedures for at least 1 hour prior to saliva sampling\n\nExclusion Criteria:\n\n* Pregnancy\n* Epilepsy\n* Presence of a pacemaker or other active electronic implant\n* Coagulation disorders\n* Active infection at the site of acupuncture\n* Systemic inflammatory diseases\n* Oral inflammatory conditions (e.g., gingivitis or periodontitis)\n* Hyposalivation\n* Chronic opioid use\n* Psychiatric conditions that may affect pain or stress assessment\n* Use of nonsteroidal anti-inflammatory drugs, corticosteroids, or antibiotics within 7 days prior to the procedure\n* Menstruation at the time of saliva sampling\n* Inability or unwillingness to comply with study procedures","ALL","25 Years","35 Years",{"count":80,"type":81},60,"ESTIMATED","INTERVENTIONAL",[84],"NA","This randomized controlled trial investigates the effect of electroacupuncture as an adjunct to local anesthesia on perioperative pain and stress during ambulatory surgical extraction of impacted lower third molars. Participants will be randomized into three groups: electroacupuncture, sham acupuncture, and control. Pain intensity and perceived stress will be assessed using validated scales, while biological stress and nociceptive markers (salivary cortisol, alpha-amylase, and substance P), as well as hemodynamic parameters (blood pressure and heart rate), will be measured. The study aims to provide an integrated evaluation of the effects of electroacupuncture on subjective, biological, and physiological indicators of perioperative response in oral surgery.",[87,88,89],"Postoperative Pain","Stress, Psychological","Impacted Lower Third Molar",[28,91,92,93,94,95],"Dental Anxiety","Third Molar Surgery","Cortisol","Alpha-Amylase","Substance P","NOT_YET_RECRUITING","2026-03-28",{"date":99,"type":100},"2026-04-03","ACTUAL",{"date":102,"type":81},"2026-04-20",{"date":104,"type":81},"2026-12-18",{"name":5,"class":6},1]