[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100512959":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":26,"responsibleParty":42,"collaborators":26,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":47,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":26,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":26,"overallStatus":67,"whyStopped":26,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":26},{"fullName":5,"class":6},"The First Hospital of Jilin University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise and Enteral Nutrition Intervention","EXPERIMENTAL","A comprehensive postoperative management combined physical exercise intervention with oral nutritional support",[13,14],"Behavioral: Exercise Intervention","Dietary Supplement: Nutrition Intervention",{"label":16,"type":17,"description":18,"interventionNames":19},"Enteral Nutrition Intervention","ACTIVE_COMPARATOR","The control group will not receive exercise intervention, but will receive postoperative nutritional support treatment with the same standards as the experimental group.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Exercise Intervention","1. Nutrition intervention: From discharge (7-14 days after surgery) until 6 months after surgery, patients are required to take 400 kcal\u002Fday of oral nutrition supplement (ONS) in addition to their normal diet..\n2. Exercise: under the guidance of the rehabilitation therapist, the patient gradually recovers Exercise from discharge (7-14 days after the operation) to 6 months after the operation, and should ensure at least 150 minutes of moderate intensity exercise or a combination of equivalent activities per week;",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DIETARY_SUPPLEMENT","Nutrition Intervention","(1) Nutrition intervention: From discharge (7-14 days after surgery) until 6 months after surgery, patients are required to take 400 kcal\u002Fday of oral nutrition supplement (ONS) in addition to their normal diet..",[16,9],[33],{"name":34,"affiliation":5,"role":35},"Quan Wang, Dr","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Mingjie Xia, Dr","CONTACT","86-431-81875601","xmj1983@jlu.edu.cn",{"type":35,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Quan Wang","Professor","100512959","effect-of-exercise-and-enteral-nutrition-on-survival-100512959",false,"NCT05959226","Effect of Exercise and Enteral Nutrition on Survival","Effect of Exercise and Enteral Nutrition Intervention on Survival in Patients With Locally Advanced Gastric Cancer: a Prospective Multicenter Randomized Controlled Study","ENERGY","Inclusion Criteria:（1) 18 years ≤ age ≤ 70 years (2) Preoperative Karnofsky physical condition score: 0 or 1 or 2 (3) Preoperative pathological biopsy by gastroscope, histologically confirmed as adenocarcinoma (papillary adenocarcinoma, tubular adenocarcinoma, mucinous adenocarcinoma, Signet ring cell carcinoma, poorly differentiated adenocarcinoma, mixed adenocarcinoma) (4) Gastric cancer patients diagnosed with clinical stage Ib IIIc through CT, MRI, gastroscopy, and pathology (based on the 8th edition of UICC\u002FAJCC staging) (5) Abdominal enhanced CT\u002FMRI examination showed a clinical staging of cT2-4aN0-3M0 (based on AJCC-8thTNM tumor staging), and standard D2 radical surgery for gastric cancer was performed; (6) Have not received any radiotherapy, chemotherapy or immunotherapy; (7) Hemoglobin ≥ 80g\u002FL; (8) Absolute neutrophil count (ANC) ≥ 1.5 × 109\u002FL; (9) Platelets ≥ 75 × 109\u002FL; (10) ALT ≤ 2.5 times the normal upper limit value; (11) AST ≤ 2.5 times the normal upper limit value; (12) ALP ≤ 2.5 times the normal upper limit value; (13) Serum total bilirubin\\\u003C1.5 times the upper normal limit value; (14) Serum creatinine\\\u003C1 times the upper normal limit value; (15) Sign written informed consent;\n\nExclusion Criteria:\n\n1. Patients diagnosed with distant metastasis through abdominal lung CT\u002FMRI or PET-CT\n2. Pregnant or lactating women\n3. People with uncontrolled epilepsy, Central nervous system disease or mental disorders\n4. Patients with combined limb disabilities or motor dysfunction;\n5. Patients with other malignant diseases in the past five years, excluding cured skin cancer and cervical Carcinoma in situ\n6. Clinically severe (i.e. active) heart disease, such as symptomatic coronary heart disease, New York Heart Association (NYHA) grade II or more severe congestive heart failure, or severe arrhythmia requiring medication intervention, or a history of myocardial infarction within the past 6 months\n7. Have a history of cerebral infarction or cerebral hemorrhage in the past 6 months\n8. Organ transplantation requires immunosuppressive therapy\n9. Serious uncontrolled recurrent infections or other serious uncontrolled concomitant diseases\n10. The patient has complications of Grade III or above in Clavien Dindo classification or has been hospitalized for more than 14 days after surgery due to various reasons;\n11. Urgent surgery required due to tumor emergencies (bleeding, perforation, obstruction)\n12. Pulmonary function test FEV1\\\u003Cexpected value 50%\n13. Received radiotherapy, chemotherapy, or other neoadjuvant treatment before surgery","ALL","18 Years","70 Years",{"count":57,"type":58},960,"ESTIMATED","INTERVENTIONAL",[61],"NA","The present clinical trial was designed to explore the effect of postoperative physical exercise combined with enteral nutritional supplement on 3-year disease-free survival in patients with advanced gastric cancer.",[64,65,66],"Gastric Cancer","Nutrition Related Cancer","Sarcopenia","NOT_YET_RECRUITING","2023-07-17",{"date":70,"type":71},"2023-07-25","ACTUAL",{"date":73,"type":58},"2023-08-01",{"date":75,"type":58},"2028-08-01",{"name":5,"class":6}]