[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641639":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":37,"responsibleParty":50,"collaborators":25,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":25,"enrollmentInfo":62,"targetDuration":25,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":25,"overallStatus":71,"whyStopped":25,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"CHU de Reims","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Muscle Strengthening Before Endurance Training (MS-ET)","EXPERIMENTAL","Participants assigned to this arm will follow a standardized pulmonary rehabilitation program in which muscle strengthening exercises are systematically performed before cardiorespiratory endurance training within each rehabilitation session. The overall content, frequency, duration, and intensity of the rehabilitation program are identical to those of the comparison arm; only the intra session order of the exercise components differs. Sessions are conducted three times per week over an eight week period under professional supervision.",[13],"Other: Pulmonary Rehabilitation - Strength First",{"label":15,"type":16,"description":17,"interventionNames":18},"Endurance Training Before Muscle Strengthening (ET-MS)","ACTIVE_COMPARATOR","Participants assigned to this arm will follow a pulmonary rehabilitation program in which muscle strengthening exercises within each rehabilitation session is systematically performed before cardiorespiratory endurance training . The rehabilitation program is identical to that of the standardized arm in terms of content, frequency, duration, and intensity. The only difference between the two arms is the intra session order of endurance and strength exercises. Sessions are conducted three times per week over an eight week period under professional supervision.",[19],"Other: Pulmonary Rehabilitation - Endurance First",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Pulmonary Rehabilitation - Strength First","All participants receive the same standardized pulmonary rehabilitation program, differing only in the intra-session exercise order. Sessions are supervised, performed 3 times\u002Fweek for 8 weeks and combine cardiorespiratory endurance and peripheral muscle strengthening. Endurance training consists of 30-45min continuous exercise on a cycle ergometer, treadmill or rowing ergometer, with intensity individually prescribed from baseline exercise testing and adjusted according to tolerance and dyspnea. Strength training lasts 45-60min and targets upper- and lower-limb muscles using dumbbells, elastic bands, body-weight exercises and leg press. Initial training loads are determined from indirect 1-RM estimation. After a familiarization phase, patients perform 6 alternating upper\u002Flower-limb exercises in 3 sets of 8-12 repetitions near maximal effort, with standardized rest periods and movement tempo. Loads are progressively increased according to repetition performance and patient tolerance.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Pulmonary Rehabilitation - Endurance First","All participants receive the same standardized pulmonary rehabilitation program, differing only in the intra-session exercise order. Sessions are supervised, performed 3 times\u002Fweek for 8 weeks and combine cardiorespiratory endurance and peripheral muscle strengthening. Endurance training consists of 30-45min continuous exercise on a cycle ergometer, treadmill or rowing ergometer, with intensity individually prescribed from baseline exercise testing and adjusted according to tolerance and dyspnea. Strength training lasts 45-60min and targets upper- and lower-limb muscles using dumbbells, elastic bands, body-weight exercises and leg press. Initial training loads are determined from indirect 1-RM estimation. After a familiarization phase, patients perform 6 alternating upper\u002Flower-limb exercises in 3 sets of 8-12 repetitions near maximal effort, with standardized rest periods and movement tempo. Loads are progressively increased according to repetition performance and patient tolerance",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Amandine RAPIN","CONTACT","03 26 78 42 60","0033","arapin@chu-reims.fr",[38],{"facility":39,"status":25,"city":40,"state":25,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":25},"Chu Reims","Reims","51092","France","FR",{"type":45,"coordinates":46},"Point",[47,48],4.02853,49.26526,{"lat":48,"lon":47},{"type":51,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100641639","effect-of-exercise-order-during-pulmonary-rehabilitation-on-muscle-strength-in-patients-with-copd-100641639",false,"NCT07655011","Effect of Exercise Order During Pulmonary Rehabilitation on Muscle Strength in Patients With COPD","Effect of Intra-Session Training Order of Cardiorespiratory Endurance Work and Muscle Strengthening in COPD Patients","ISTOR-COPD","Inclusion Criteria:\n\n* Age ≥ 18 years\n* COPD GOLD stages 2 to 4\n* Admitted for pulmonary rehabilitation in a participating center\n* Ability to read and speak French\n* Written informed consent\n* Affiliation with a social security system\n\nExclusion Criteria:\n\n* Legal protection (guardianship or trusteeship)\n* Pregnancy beyond the second trimester\n* Musculoskeletal disorders affecting lower limb strength or walking performance\n* Vascular disease limiting walking distance\n* Cardiac contraindication to pulmonary rehabilitation","ALL","18 Years",{"count":63,"type":64},138,"ESTIMATED","INTERVENTIONAL",[67],"NA","Chronic Obstructive Pulmonary Disease (COPD) is a chronic multisystem disease frequently associated with peripheral muscle dysfunction, which is strongly linked to prognosis and survival. Pulmonary rehabilitation is a cornerstone of COPD management and includes both cardiorespiratory endurance training and muscle strengthening exercises. Although these components are routinely combined within rehabilitation programs, the optimal order in which they should be performed during the same training session remains unclear.\n\nIn healthy individuals, performing endurance and strength exercises in different sequences within a single session may influence muscular adaptations, a phenomenon referred to as the intra session interference effect. This effect has never been studied in patients with COPD undergoing pulmonary rehabilitation. Given the high prevalence and clinical importance of muscle weakness in COPD, optimizing exercise prescription may improve functional outcomes and long term benefits.\n\nThis multicenter randomized controlled trial aims to compare two pulmonary rehabilitation strategies that differ only in the order of exercise administration. Participants with moderate to severe COPD will be randomly assigned to perform either muscle strengthening before endurance training or endurance training before muscle strengthening during each rehabilitation session.\n\nThe primary objective is to evaluate the impact of exercise order on lower limb muscle strength, assessed by the Five Times Sit to Stand test at the end of the rehabilitation program. Secondary objectives include assessment of exercise capacity, dyspnea, muscle and inflammatory biomarkers, tolerance, and adherence to the rehabilitation program, as well as follow up evaluations up to 12 months after completion.\n\nThe results of this study are expected to provide evidence to optimize pulmonary rehabilitation programs for patients with COPD and to inform clinical practice regarding exercise sequencing.",[70],"Chronic Obstructive Pulmonary Disease (COPD)","NOT_YET_RECRUITING","2026-06-12",{"date":74,"type":75},"2026-06-17","ACTUAL",{"date":77,"type":64},"2026-08",{"date":79,"type":64},"2030-01",{"name":5,"class":6},1]