[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625547":3},{"organization":4,"armGroups":7,"interventions":37,"overallOfficials":42,"centralContacts":61,"locations":42,"responsibleParty":67,"collaborators":42,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":42,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":42,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":99,"whyStopped":42,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":42},{"fullName":5,"class":6},"Al-Azhar University","OTHER",[8,14,19,24,28,32],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1: will receive Graphene Oxide using vital pulpotomy technique","EXPERIMENTAL","Group 1: Vital Teeth will receive Graphene Oxide using vital pulpotomy technique (study group, n=21)",[13],"Other: Graphene Oxide using vital pulpotomy technique",{"label":15,"type":10,"description":16,"interventionNames":17},"Group 2: MTA using vital pulpotomy technique","Group 2: will receive MTA using vital pulpotomy technique (study group, n=21)",[18],"Other: MTA using vital pulpotomy technique",{"label":20,"type":21,"description":20,"interventionNames":22},"Group 3: will receive Zinc Oxide and Eugenol using vital pulpotomy technique (control group, n=21)","ACTIVE_COMPARATOR",[23],"Other: Zinc Oxide and Eugenol using vital pulpotomy technique",{"label":25,"type":10,"description":25,"interventionNames":26},"Group a: will receive Graphene Oxide using non-vital pulpotomy technique (study group, n=21).",[27],"Other: Graphene Oxide using non-vital pulpotomy technique",{"label":29,"type":10,"description":29,"interventionNames":30},"Group b: will receive LSTR using non-vital pulpotomy technique (study group, n=21).",[31],"Other: LSTR using non-vital pulpotomy technique",{"label":33,"type":21,"description":34,"interventionNames":35},"Group c: will receive Zinc Oxide and Eugenol using non-vital pulpotomy (Control group, n=21)","Group c: will receive Zinc Oxide and Eugenol using non-vital pulpotomy (Control group, n=21).",[36],"Other: Zinc Oxide and Eugenol using non-vital pulpotomy",[38,43,47,51,55,58],{"type":6,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Graphene Oxide using vital pulpotomy technique","After administering local anesthesia, the tooth will be isolated with a rubber dam. All caries will be removed, and coronal access will be gained using a sterile No. 330 bur mounted on a water-cooled high-speed turbine to expose the pulp chamber. A spoon excavator will be used for coronal pulp amputation. The pulp chamber will then be irrigated with saline solution to remove all debris. Hemostasis will be obtained with a moistened cotton pellet gently pressed against the amputated pulp stumps in both groups. Hemorrhage should stop within 5 min of applying the cotton pellet. Graphene Oxide will be applied to cover the pulp chamber. will be prepared as per the manufacturer's instructions to obtain a putty-like consistency. The mixture will be delivered to the pulp stumps and condensed lightly with a moistened sterile cotton pellet. A thick mix of the material will be applied Teeth of all tested groups will be restored after the pulp therapy using high-viscosity glass ionomer",[9],null,{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":42},"MTA using vital pulpotomy technique","After administering local anesthesia, the tooth will be isolated with a rubber dam. All caries will be removed, and coronal access will be gained using a sterile No. 330 bur mounted on a water-cooled high-speed turbine to expose the pulp chamber. A spoon excavator will be used for coronal pulp amputation. The pulp chamber will then be irrigated with saline solution to remove all debris. Hemostasis will be obtained with a moistened cotton pellet gently pressed against the amputated pulp stumps in both groups. Hemorrhage should stop within 5 min of applying the cotton pellet. MTA will be applied to cover the pulp chamber. will be prepared as per the manufacturer's instructions to obtain a putty-like consistency. The mixture will be delivered to the pulp stumps and condensed lightly with a moistened sterile cotton pellet. A thick mix of the material will be applied Teeth of all tested groups will be restored after the pulp therapy using high-viscosity glass ionomer",[15],{"type":6,"name":48,"description":49,"armGroupLabels":50,"otherNames":42},"Zinc Oxide and Eugenol using vital pulpotomy technique","After administering local anesthesia, the tooth will be isolated with a rubber dam. All caries will be removed, and coronal access will be gained using a sterile No. 330 bur will be mounted on a water-cooled high-speed turbine to expose the pulp chamber. A spoon excavator will be used for coronal pulp amputation. The chamber will then be irrigated with saline solution to remove all debris. Hemostasis will be obtained with a moistened cotton pellet gently pressed against the amputated pulp stumps in both groups. Hemorrhage should stop within 5 min of applying the cotton pellet. Zinc oxide Eugenol will be applied to cover the pulp chamber. will be prepared as per the manufacturer's instructions to obtain a putty-like consistency. The mixture will be delivered to the pulp stumps and condensed lightly with a moistened sterile cotton pellet. A thick mix of the material will be applied Teeth of all tested groups will be restored after the pulp therapy using high-viscosity glass ionomer",[20],{"type":6,"name":52,"description":53,"armGroupLabels":54,"otherNames":42},"Graphene Oxide using non-vital pulpotomy technique","Absolute isolation with a rubber dam. Decayed dentin will be removed using spoon-shaped dentin excavators. The pulp chamber roof will be removed with a high-speed sterile carbide bur number 330, followed by irrigating the pulp chamber with two percent chlorhexidine solution and drying it with cotton balls.\n\nAfter these steps, a non-vital pulpotomy will be performed The coronal parts will be restored by preformed stainless steel crowns.",[25],{"type":6,"name":56,"description":53,"armGroupLabels":57,"otherNames":42},"LSTR using non-vital pulpotomy technique",[29],{"type":6,"name":59,"description":53,"armGroupLabels":60,"otherNames":42},"Zinc Oxide and Eugenol using non-vital pulpotomy",[33],[62],{"name":63,"role":64,"phone":65,"phoneExt":42,"email":66},"Mennah Helal, Master of science","CONTACT","00201009230087","mennah.helal2020@outlook.com",{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"PRINCIPAL_INVESTIGATOR","MENNA HELAL","PHD Candidate, Pediatric Dentistry Department, Azhar University","100625547","effect-of-graphene-oxide-on-vital-and-non-vital-primary-teeth-compared-to-the-conventional-techniques-100625547",false,"NCT07424053","Effect of Graphene Oxide on Vital and Non-Vital Primary Teeth Compared to the Conventional Techniques","Effect of Graphene Oxide on Vital and Non-Vital Primary Teeth Compared to the Conventional Techniques: Randomized Multi-Arm Clinical Trial","\\*Inclusion Criteria\\* (First Arm)\n\n* Cooperative child\n* Presence of symptom-free deep carious lesions\n* Presence of at least two-thirds of the root length radiographically; restorable tooth\n\n(Second Arm)\n\n* Primary teeth diagnosed with pulp necrosis, root resorption equal to or less than one-third (with sufficient dental structure for absolute isolation with rubber dam)\n* History of spontaneous pain and mobility incompatible with chronological age, possibly with the presence of a sinus tract or swelling\n* Presence or absence of a radiolucent area in the periapical or furcation region\n\n\\*Exclusion Criteria\\* (First Arm)\n\n* History of systemic diseases\n* Teeth showing clinical and radiographical evidence of pulp degeneration, such as history of spontaneous or nocturnal pain, tenderness to percussion or palpation, pathologic mobility, swelling or fistulous tract, periodontal ligament (PDL) space widening, internal root resorption, external root resorption, furcal radiolucency\u002Finter-radicular bone destruction, and\u002For periapical bone destruction\n* Teeth without a permanent successor\n* Teeth requiring more than 5 minutes to achieve hemostasis during the clinical procedure\n\n(Second Arm)\n\n* Children with a history of allergic reaction to the components of the tested materials\n* Children had used antibiotics in the last three months.\n* Teeth with pulp canal obliteration or internal or external pathological root resorption visible in periapical radiographs\n* Coronal destruction that would prevent absolute isolation with a rubber dam and\u002For restoration","ALL","5 Years","10 Years",{"count":82,"type":83},126,"ESTIMATED","INTERVENTIONAL",[86],"NA","The null hypothesis of the current study suggested that there will be no significant difference regarding the effect of Graphene Oxide (GO), Lesion sterilization and tissue repair (LSTR) and Zinc Oxide and Eugenol on the clinical and radiographic success rate of non-vital pulpotomy of primary teeth and that there will be no significant difference regarding the effect of Graphene Oxide (GO), MTA and Zinc Oxide and Eugenol on the clinical and radiographic success rate of vital pulpotomy of primary teeth.\n\nThe children (n=126) will be divided randomly into 2 arms; each arm has 3 groups, according to the type of pulp therapy dressing, medicament,t and technique of its application as follows:\n\nFirst Arm (Vital Teeth) Group 1: will receive Graphene Oxide using the vital pulpotomy technique (study group, n=21) Group 2: will receive MTA using vital pulpotomy technique (study group, n=21) Group 3: will receive Zinc Oxide and Eugenol using the vital pulpotomy technique (control group, n=21) Second Arm (Non-Vital Teeth) Group A: will receive Graphene Oxide using the non-vital pulpotomy technique (study group, n=21).\n\nGroup B: will receive LSTR using the non-vital pulpotomy technique (study group, n=21).\n\nGroup C: will receive Zinc Oxide and Eugenol using non-vital pulpotomy (Control group, n=21).\n\nClinical and radiographic success will be assessed as primary outcomes, while pain, patient satisfaction,n and time of procedure will be assessed as secondary outcomes.",[89],"Primary Teeth Indicated for Pulp Therapy",[91,92,93,94,95,96,97,98],"LSTR","MTA","Zinc Oxide and Eugenol","Graphene Oxide","Vital pulpotomy","Non Vital Pulpotomy","Primary teeth","Conventional Pulp therapy techniques","NOT_YET_RECRUITING","2026-02-19",{"date":102,"type":103},"2026-02-20","ACTUAL",{"date":105,"type":83},"2026-04",{"date":107,"type":83},"2026-12-01",{"name":5,"class":6}]