[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100173181":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":33,"locations":43,"responsibleParty":108,"collaborators":24,"id":111,"slug":112,"hasResults":113,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":24,"eligibilityCriteria":117,"healthyVolunteers":113,"sex":118,"minAge":119,"maxAge":24,"enrollmentInfo":120,"targetDuration":24,"studyType":123,"phases":124,"briefSummary":126,"conditions":127,"keywords":129,"overallStatus":46,"whyStopped":24,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":140},{"fullName":5,"class":6},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard glucose management","PLACEBO_COMPARATOR","Arterial-blood glucose levels will be checked at induction of anesthesia and every 30 - 60 min thereafter with an StatStrip Xpress® (Nova Biomedical, MA, USA) ( A blood glucose level above 10 mmol\u002Fl will be treated with a 2U bolus of IV insulin (Humulin® R regular insulin, Eli Lilly and Company, Indianapolis, IN) followed by a 1 U\u002Fhour drip infusion adjusted according to a standard sliding scale",[13],"Other: Standard glucose management",{"label":15,"type":16,"description":17,"interventionNames":18},"Hyperinsulinemic normoglycemic clamp","ACTIVE_COMPARATOR","The blood glucose level will be checked prior to intubation. A 2U bolus of IV insulin will be given if blood glucose level is higher than 6 mmol\u002Fl, followed by an IV infusion of 2 U\u002Fkg\u002Fmin (0.12 U\u002Fkg\u002Fhour). Dextrose 20% (D20W®) will be titrated to maintain blood glucose between 4 and 6 mmol\u002Fl. Blood glucose levels will be measured at 5-30 min intervals with a to ensure normoglycemia. At the end of surgery, the insulin infusion will be stopped, and the dextrose infusion weaned off in the post anesthesia care unit.",[19],"Other: Hyperinsulinemic normoglycemic clamp",[21,25],{"type":6,"name":15,"description":22,"armGroupLabels":23,"otherNames":24},"Patients will receive an IV infusion of 2 mU\u002Fkg\u002Fmin (0.12 U\u002Fkg\u002Fhour) starting in the operating room. Dextrose 20% will be titrated to maintain blood glucose between 4 and 6 mmol\u002Fl. At the end of surgery, the insulin infusion will be stopped and the dextrose infusion weaned off in the postanesthesia care unit.",[15],null,{"type":6,"name":9,"description":26,"armGroupLabels":27,"otherNames":24},"Blood glucose levels will be treated by a standard insulin sliding scale.",[9],[29],{"name":30,"affiliation":31,"role":32},"Ralph Lattermann, MD PhD","Department of Anaesthesia, McGill University Health Center","PRINCIPAL_INVESTIGATOR",[34,39],{"name":30,"role":35,"phone":36,"phoneExt":37,"email":38},"CONTACT","514-934-1934","37023","ralph.lattermann@gmail.com",{"name":40,"role":35,"phone":36,"phoneExt":41,"email":42},"Thomas Schricker, MD PhD","36057","thomas.schricker@mcgill.ca",[44,74,91],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Royal Victoria Hospital, McGill University Health Centre","RECRUITING","Montreal","Quebec","H3A 1A1","Canada","CA",{"type":53,"coordinates":54},"Point",[55,56],-73.58781,45.50884,{"lat":56,"lon":55},[59,62,63,64,66,68,70,72],{"name":30,"role":35,"phone":36,"phoneExt":60,"email":61},"35802","ralph.lattermann@muhc.mcgill.ca",{"name":40,"role":35,"phone":36,"phoneExt":41,"email":42},{"name":30,"role":32,"phone":24,"phoneExt":24,"email":24},{"name":40,"role":65,"phone":24,"phoneExt":24,"email":24},"SUB_INVESTIGATOR",{"name":67,"role":65,"phone":24,"phoneExt":24,"email":24},"George Carvalho, MD MSc",{"name":69,"role":65,"phone":24,"phoneExt":24,"email":24},"Peter Metrakos, MD",{"name":71,"role":65,"phone":24,"phoneExt":24,"email":24},"Linda Wykes, PhD",{"name":73,"role":65,"phone":24,"phoneExt":24,"email":24},"Mazen Hassanain, MD",{"facility":75,"status":76,"city":47,"state":48,"zip":77,"country":50,"countryCode":51,"cosmosGeoPoint":78,"geoPoint":80,"contacts":81},"Royal Victoria Hospital","NOT_YET_RECRUITING","H3A1A1",{"type":53,"coordinates":79},[55,56],{"lat":56,"lon":55},[82,83,84,86,87,89],{"name":30,"role":35,"phone":36,"phoneExt":37,"email":38},{"name":40,"role":35,"phone":36,"phoneExt":41,"email":42},{"name":85,"role":65,"phone":24,"phoneExt":24,"email":24},"Roupen Hatzakorzian, MD",{"name":69,"role":65,"phone":24,"phoneExt":24,"email":24},{"name":88,"role":65,"phone":24,"phoneExt":24,"email":24},"Prosanto Chaudhury, MD MSc",{"name":90,"role":65,"phone":24,"phoneExt":24,"email":24},"Charles Frenette, MD",{"facility":92,"status":76,"city":93,"state":94,"zip":95,"country":96,"countryCode":97,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Hospital Clinico Universidad de Chile","Independencia","Santiago Metropolitan","8380456","Chile","CL",{"type":53,"coordinates":99},[100,101],-70.66647,-33.41167,{"lat":101,"lon":100},[104],{"name":105,"role":35,"phone":106,"phoneExt":24,"email":107},"Daniela B Advis, M.D.","+5629788211","dbravoadvis@uchile.cl",{"type":32,"investigatorFullName":109,"investigatorTitle":110,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Ralph Lattermann","Assistant Professor, Department of Anesthesia","100173181","effect-of-high-dose-insulin-on-infectious-complications-following-major-surgery-100173181",false,"NCT01528189","Effect of High Dose Insulin on Infectious Complications Following Major Surgery","Effect of Hyperinsulinemic Normoglycemic Clamp (HINC) on Infectious Complications Following Major Abdominal Surgery. A Randomized Controlled Trial.","Inclusion Criteria:\n\n* \\> 18 years old\n* elective liver, pancreatic or colorectal surgery\n* ability to give informed consent\n\nExclusion Criteria:","ALL","18 Years",{"count":121,"type":122},460,"ESTIMATED","INTERVENTIONAL",[125],"NA","Despite improvements in surgical techniques and perioperative care, the high incidence of postoperative surgical site infections remains a major problem in patients undergoing major abdominal surgery (liver, pancreatic and colorectal surgery).\n\nUsing the hyperinsulinemic-normoglycemic clamp technique, i.e. continuous infusion of insulin combined with dextrose titrated to \"clamp\" blood glucose between 4 and 6 mmol\u002FL, we successfully established and preserved normoglycemia during the perioperative period. Our objective of this study is to determine if the maintenance of perioperative normoglycemia by a hyperinsulinemic normoglycemic clamp reduces the rates of incisional and space\u002F surgical site infections following abdominal surgery (liver, pancreatic and colorectal surgery).",[128],"Surgical Site Infection After Major Surgery",[130],"Insulin, surgery, infection","2025-05-05",{"date":133,"type":134},"2025-05-08","ACTUAL",{"date":136,"type":134},"2018-10-05",{"date":138,"type":122},"2025-12",{"name":5,"class":6},3]