[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100543713":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":40,"locations":47,"responsibleParty":64,"collaborators":66,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":25,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":50,"whyStopped":25,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University Hospital, Ghent","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Combined strength + aerobic training","ACTIVE_COMPARATOR","The patients in this group will exercise for 14 weeks. It is a combination of strength and aerobic exercise.",[13],"Other: Combined aerobic + strength training",{"label":15,"type":16,"description":17,"interventionNames":18},"Combined strength + HIIT","EXPERIMENTAL","The patients in this group will exercise for 14 weeks. The first 6 weeks consists of combined aerobic and strength exercise, following the protocol from the active comparator group.\n\nThey will switch to combined strength and HIIT exercise for the remaining 8 weeks.",[19],"Other: Combined strength + HIIT training",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Combined aerobic + strength training","Participants will follow a combination of endurance and strength training for 14 weeks.\n\nThere will be three sessions every week: two at Ghent university department of rehabilitation and one at home. Each session will last approximately one hour.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Combined strength + HIIT training","6 weeks of endurance training and strength training, 8 weeks of strength training and HIIT.\n\nParticipants will follow the same combination of endurance and strength training for the first six weeks, to build up to a baseline level of physical fitness. They will then switch to eight weeks of a combination of strength training and High Intensity Interval Training (HIIT).\n\nThere will be three sessions every week: two at Ghent university department of rehabilitation and one at home. Each session will last approximately one hour.",[15],[31,35,37],{"name":32,"affiliation":33,"role":34},"Patrick Calders, Prof. dr.","University Ghent","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":5,"role":34},"Anja Geerts, Prof. dr.",{"name":38,"affiliation":33,"role":39},"Sander Lefere, dr.","STUDY_CHAIR",[41,45],{"name":32,"role":42,"phone":43,"phoneExt":25,"email":44},"CONTACT","0032498354766","patrick.calders@ugent.be",{"name":38,"role":42,"phone":25,"phoneExt":25,"email":46},"sander.lefere@ugent.be",[48],{"facility":49,"status":50,"city":51,"state":25,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Ghent University Hospital","RECRUITING","Ghent","9000","Belgium","BE",{"type":56,"coordinates":57},"Point",[58,59],3.71667,51.05,{"lat":59,"lon":58},[62],{"name":63,"role":42,"phone":25,"phoneExt":25,"email":25},"Anja Geerts, MD, PhD",{"type":65,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[67],{"name":5,"class":6},"100543713","effect-of-high-intensity-exercise-rehabilitation-on-liver-function-and-insulin-sensitivity-in-patients-with-masld-100543713",false,"NCT06359444","Effect of High Intensity Exercise Rehabilitation on Liver Function and Insulin Sensitivity in Patients With MASLD","Effect of High Intensity Exercise Rehabilitation on Hepatic Fatty Acids (Liver Function), Insulin Sensitivity and Cardiovascular Risk in Patients With MASLD","CENSORIAL","Inclusion Criteria:\n\n* Diagnosed with MASLD by ultrasound, CAP and\u002For biopsy\n* Age between 18 and 75 years old\n* No significant liver fibrosis (Fibroscan \\\u003C 7.5 kPa; if it is between \\>7.5 and \\\u003C10, there must be absence of liver fibrosis in the biopsy)\n\nExclusion Criteria:\n\n* Presence of other liver diseases that may contribute to the clinical presentation in the patient\n* Severe cardiovascular, orthopedic, physical or other illnesses that make it impossible to participate in the study's exercise rehabilitation program or where safety cannot be guaranteed\n* Pregnancy\n* Pharmacological treatment that directly affects MASLD (e.g. GLP-1 analogues)\n* A change in medication in the last three months before the study that affects metabolic disease stability","ALL","18 Years","75 Years",{"count":80,"type":81},92,"ESTIMATED","INTERVENTIONAL",[84],"NA","Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide, and is associated with obesity and the metabolic syndrome. Physical activity and lifestyle interventions are among the most recommended treatments for individuals with MASLD.\n\nIn this RCT, we will evaluate the effect of combined exercise training \"strength and aerobic training\" versus \"strength and high intensity training (HIIT)\". The main outcome parameter is the severity of liver steatosis. Patients will be recruited at the fatty liver clinic of the UZ Gent.",[87,88],"Exercise Therapy","Metabolic Dysfunction-associated Steatotic Liver Disease",[90,91,92],"exercise","MASLD","liver diseases","2024-06-06",{"date":95,"type":96},"2024-06-07","ACTUAL",{"date":98,"type":96},"2024-04-26",{"date":100,"type":81},"2026-03-15",{"name":33,"class":6},1]