[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632045":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":30,"responsibleParty":49,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":10,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Sakarya University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Elective On-Pump CABG Patients Undergoing CPB",null,"Adult patients undergoing elective on-pump coronary artery bypass grafting with cardiopulmonary bypass will be included. All participants will receive standard general anesthesia and intraoperative management according to institutional protocols. Bispectral Index (BIS) and Patient State Index (PSI) will be monitored simultaneously throughout surgery. Data will be collected at predefined time points across normothermic, hypothermic, and rewarming phases of cardiopulmonary bypass to evaluate the relationship between these indices under varying temperature conditions.",[13],"Other: Simultaneous BIS and PSI Monitoring",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Simultaneous BIS and PSI Monitoring","This observational study does not involve any experimental intervention. All participants will receive standard anesthesia and surgical care according to institutional protocols. The study focuses on simultaneous intraoperative monitoring using Bispectral Index (BIS) and Patient State Index (PSI) devices. Sensors for both monitors will be applied prior to induction of anesthesia, and values will be recorded at predefined time points during normothermic, hypothermic, and rewarming phases of cardiopulmonary bypass. No changes will be made to routine clinical management, and all treatments will be determined by the attending anesthesiologist.",[9],[20],{"name":21,"affiliation":22,"role":23},"AYÇA TAŞ TUNA, Professor, M.D.","Sakarya University Faculty of Medicine","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"AHMET R DOĞAN, M.D","CONTACT","+905427988070","a.ridvandogan@gmail.com",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":10,"country":36,"countryCode":10,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Sakarya University Training and Research Hospital, Department of Anesthesiology and Reanimation","RECRUITING","Sakarya","Serdivan","Turkey (Türkiye)",{"type":38,"coordinates":39},"Point",[40,41],32.07583,39.50333,{"lat":41,"lon":40},[44,46],{"name":45,"role":27,"phone":28,"phoneExt":10,"email":29},"AHMET R DOĞAN",{"name":47,"role":48,"phone":10,"phoneExt":10,"email":10},"Ahmet R Dogan","SUB_INVESTIGATOR",{"type":23,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Ayça Taş Tuna","Prof.Dr.","100632045","effect-of-hypothermia-on-bis-and-psi-correlation-during-cardiopulmonary-bypass-100632045",false,"NCT07508579","Effect of Hypothermia on BIS and PSI Correlation During Cardiopulmonary Bypass","Effect of Hypothermia on the Correlation Between Bispectral Index (BIS) and Patient State Index (PSI) During Cardiopulmonary Bypass","Inclusion Criteria:\n\n* Age ≥18 years\n* Elective on-pump Coronary Artery Bypass Grafting (CABG) surgery\n* Planned use of general anesthesia\n* Written informed consent\n\nExclusion Criteria:\n\n* Preexisting neurological disease\n* Use of medications affecting Electroencephalography (e.g., antiepileptics)\n* Severe hepatic dysfunction\n* Emergency surgery\n* Inadequate signal quality for anesthesia depth monitoring","ALL","18 Years","80 Years",{"count":63,"type":64},60,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to evaluate whether hypothermia affects the relationship between electroencephalography-derived indices during cardiac surgery in adult patients undergoing cardiopulmonary bypass.\n\nThe main questions it aims to answer are:\n\nDoes the correlation between Bispectral Index (BIS) and Patient State Index (PSI) change between normothermic and hypothermic phases during cardiopulmonary bypass? How do BIS and PSI values change in response to decreasing body temperature?\n\nParticipants will:\n\nUndergo standard general anesthesia for elective on-pump coronary artery bypass surgery Be monitored simultaneously with BIS and PSI devices during surgery Have data recorded at predefined temperature-based time points during cardiopulmonary bypass",[68,69,70],"Cardiopulmonary Bypass","Hypothermia; Anesthesia","Depth of Anesthesia Monitoring",[72,73,74,75,76,77,78],"Bispectral Index","Patient State Index","Processed EEG","Cardiac Surgery","Hypothermic CPB","Depth of Anesthesia","Intraoperative Monitoring","2026-05-05",{"date":81,"type":82},"2026-05-11","ACTUAL",{"date":84,"type":82},"2026-05-01",{"date":86,"type":64},"2026-12-31",{"name":5,"class":6},1]