[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617413":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":60,"collaborators":26,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":26,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Jordan University of Science and Technology","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"placebo extraction side","PLACEBO_COMPARATOR","Surgical extraction of wisdom tooth with placebo administration inside the extraction site using collagen sponge",[13,14],"Procedure: Surgical extraction of wisdom teeth","Procedure: bone biobsy",{"label":16,"type":17,"description":18,"interventionNames":19},"experimental extraction side","EXPERIMENTAL","Surgical extraction of wisdom tooth with placebo administration inside the extraction site using hyaluronic acid gel",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Surgical extraction of wisdom teeth","A standardized surgical procedure was performed by a single experienced surgeon (ZA). Under strict aseptic conditions, an inferior alveolar nerve block with buccal infiltration, was given using lidocaine HCl 2% with epinephrine 1:100,000 (Cook-Waite, Rochester, NY). A mucoperiosteal envelope flap was utilized for all surgeries. Bone removal and tooth sectioning were performed as deemed necessary using a low-speed handpiece under copious saline irrigation. After tooth removal, HA gel (Hyadent) was placed inside the extraction socket and covered with collagen sponge in the test sockets, while only coverage with collagen sponge was placed in the control sockets. Subsequently, flap closure was achieved using 3-0 silk sutures",[16,9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"bone biobsy","After 6 weeks, core biopsies are taken from both sides. Under local anesthesia, the core biopsies sre taken without reflection of a flap, using a graded trephine bur (MCT, Korea) of 3 mm diameter (which is not invasive or having any complication) for later histological evaluation. Specimens harvested from each patient are fixed in 10% formalin, then decalcified using 10% hydrochloric acid. After processing, 5 micrometer sections are prepared and stained with hematoxylin and eosin stain (H\\&E).\n\nDigital images are acquired from each section at a magnification of × 40. ImageJ 1.52a software (National Institute of Health, Bethesda, Maryland, USA) is used to calculate the percentage of woven bone area within selected regions of interest (ROI) in each image, utilizing the color thresholding feature. To ensure that measurements are valid, 3 measurements are made for each of the hard tissue and soft tissue components, and for the total area of the ROI in pixels.",[16,9],[32],{"name":33,"affiliation":5,"role":34},"Rola Habashneh, Professor","STUDY_CHAIR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Tamimi","CONTACT","00962795036670","zztamimi@just.edu.jo",[42],{"facility":43,"status":44,"city":45,"state":26,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Higher specialty training center","RECRUITING","Irbid","11196","Jordan","JO",{"type":50,"coordinates":51},"Point",[52,53],35.85,32.55556,{"lat":53,"lon":52},[56],{"name":57,"role":38,"phone":58,"phoneExt":26,"email":59},"rola Habashneh, Professor","0096227201000","raalhabashneh@just.edu.jo",{"type":61,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100617413","effect-of-injectable-hyaluronic-acid-hyadent-bg-ha-on-bone-healing-in-extraction-sockets-100617413",false,"NCT07318298","Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets","Inclusion Criteria:\n\nMale and female participants aged 18 to 35 years\n\nPresence of bilateral impacted mandibular third molars classified as Pell and Gregory Class II, Position B\n\nClassified as American Society of Anesthesiologists (ASA) Physical Status I\n\nAbsence of active local infection at the surgical site (e.g., no swelling, trismus, hyperthermia)\n\nAbility to maintain adequate oral hygiene\n\nAbility to understand and provide written informed consent\n\nAbility to read and understand Arabic or English\n\nWillingness to comply with study procedures and follow-up visits\n\nExclusion Criteria:\n\nHistory of systemic diseases such as diabetes mellitus, hypertension, gastric ulcer, or other significant medical conditions\n\nPresence of severe or chronic illness requiring frequent hospitalization\n\nPregnant or breastfeeding individuals\n\nHistory of cognitive or motor impairment that may interfere with study participation\n\nUse of anti-inflammatory or analgesic medications within two weeks before surgery\n\nKnown allergy or hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs)\n\nCurrent smoker\n\nUse of anticoagulant therapy\n\nAny condition that, in the investigator's judgment, may interfere with healing or study outcomes",true,"ALL","18 Years","35 Years",{"count":73,"type":74},20,"ESTIMATED","INTERVENTIONAL",[77],"NA","Complications such as postoperative pain and delayed socket healing are relatively common following surgical extraction of mandibular third molars. Various biomaterials have been investigated to enhance wound healing and reduce postoperative morbidity. Hyaluronic acid (HA) has demonstrated anti-inflammatory and regenerative properties that may improve both soft and hard tissue healing.\n\nThe aim of this study is to evaluate the effect of topical hyaluronic acid on postoperative pain and alveolar socket bone healing following surgical extraction of mandibular third molars. A prospective, randomized, controlled clinical trial with a split-mouth design will be conducted. Twenty patients requiring bilateral mandibular third molar surgical extraction will be enrolled. In each patient, one extraction socket will receive hyaluronic acid combined with a collagen sponge, while the contralateral socket will receive a collagen sponge alone, according to random allocation. Postoperative pain will be assessed using a visual analogue scale, and socket healing will be evaluated radiographically and histologically.",[80],"The Application of Hyaluronic Acid on Teeth Bone Healing. Hyaluronic Acid Which is Widely Used in Medicine for Joint, Eye Care, Wound Healing",[82],"hyauronic acid, wisdom teeth extraction, bone healing","2026-01-27",{"date":85,"type":86},"2026-01-28","ACTUAL",{"date":88,"type":86},"2024-08-01",{"date":90,"type":74},"2026-04-30",{"name":5,"class":6},1]