[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100054131":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":26,"locations":26,"responsibleParty":27,"collaborators":26,"id":29,"slug":30,"hasResults":31,"nctId":32,"briefTitle":33,"officialTitle":34,"acronym":26,"eligibilityCriteria":35,"healthyVolunteers":31,"sex":36,"minAge":37,"maxAge":38,"enrollmentInfo":39,"targetDuration":26,"studyType":42,"phases":43,"briefSummary":45,"conditions":46,"keywords":49,"overallStatus":51,"whyStopped":26,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":26},{"fullName":5,"class":6},"The Hong Kong Polytechnic University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Inspiratory Muscle Training","EXPERIMENTAL","5 sessions\u002Fweek for 8 weeks. Load starts at 50% MIP for 40 reps, increases to 80% MIP for 60 reps from week 5, then adjusted weekly to 80% of updated MIP. Device: threshold inspiratory muscle trainer.",[13],"Other: Inspiratory muscle training",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Inspiratory Muscle Training","SHAM_COMPARATOR","Participants perform sham inspiratory muscle training with the same frequency and duration as the experimental group, but the inspiratory load is fixed at 10% of maximal inspiratory pressure (MIP) and does not progress. All other procedures (weekly MIP measurement for sham load adjustment) are identical to maintain blinding.",[13],[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Inspiratory muscle training","Participants will perform home-based inspiratory muscle training using a threshold-loading device (POWERbreathe Medic Plus). Training is conducted 5 times per week for 8 weeks. The initial inspiratory load is set at 50% of the individual's maximum inspiratory pressure (MIP), measured weekly at the study site. The load is progressively increased to 80% MIP over the first 4 weeks and maintained at 80% MIP for the remaining 4 weeks. Each session consists of 40-60 breaths. Adherence is monitored via an electronic training log and weekly on-site visits. This protocol is individualized, progressive, and home-based, distinguishing it from fixed-load or supervised-only breathing interventions.",[9,15],[25],"Respiratory muscle training",null,{"type":28,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100054131","effect-of-inspiratory-muscle-training-on-knee-osteoarthritis-pain-100054131",false,"NCT07698418","Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain","Effect of Inspiratory Muscle Training on Pain in Patients With Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 55 years or older.\n* Knee osteoarthritis (Kellgren-Lawrence grade ≥ 2).\n* Knee pain (Visual Analogue Scale, VAS ≥ 3) on the most days in the past month.\n* Able to walk independently without assitive devices.\n\nExclusion Criteria:\n\n* History of knee replacement surgery, meniscus surgery, or ligament surgery.\n* Received corticosteroid injection within the previous three weeks.\n* Diagnosed with rheumatoid arthritis.\n* Unstable angina, recent myocardial infarction, uncontrolled cardiac arrhythmia, or severe heart failure.\n* History of stroke.\n* Currently receiving steroid therapy, hormonal therapy, or cancer chemotherapy.\n* Pneumothorax, pulmonary bullae, lung surgery within the past 12 months, unstable asthma, or severe dyspnea at rest.\n* Unable to understand the study procedures and potential risks.","ALL","55 Years","80 Years",{"count":40,"type":41},80,"ESTIMATED","INTERVENTIONAL",[44],"NA","Knee osteoarthritis (KOA) is a common joint disease that causes chronic pain and limits daily activities. Current treatments, such as painkillers or surgery, have limitations like side effects or high costs. This study will test whether a safe, non-drug intervention-inspiratory muscle training (breathing exercises against resistance)-can reduce knee pain in people with KOA. The training may work by lowering inflammation and improving the body's nervous system control of pain.\n\nWe plan to enroll 80 patients aged ≥55 years with confirmed KOA and frequent knee pain. Participants will be randomly assigned to either an 8-week inspiratory muscle training program (5 sessions per week, with gradually increasing resistance) or a sham (very low resistance) training program. Neither the patients nor the researchers assessing the outcomes will know who is in which group.\n\nThe main outcome is change in knee pain measured by a visual analog scale (VAS). Secondary outcomes include blood markers of inflammation (TNF-α, IL-6, IL1β), physical function, WOMAC score (a KOA-specific questionnaire), activity level, sleep quality, and quality of life. To explore underlying mechanisms, we will also measure heart rate variability (HRV) as an indicator of autonomic nervous system function, and brain functional connectivity in the prefrontal cortex using functional near-infrared spectroscopy (fNIRS). These mechanistic assessments will be performed at baseline and at the end of 8-week intervention. Additional follow-up assessments for clinical outcomes will be done at 3 and 6 months after the training ends. We will also record any side effects or adverse events.\n\nThis study will provide high-quality evidence on whether inspiratory muscle training is an effective and safe complementary treatment for knee pain in people with knee OA, and will offer new insights into the mechanisms underlying its analgesic effects.",[47,48],"Knee Osteoarthritis","Knee Osteoarthritis (Knee OA)",[47,9,50],"Chronic Pain","NOT_YET_RECRUITING","2026-07-07",{"date":54,"type":55},"2026-07-13","ACTUAL",{"date":57,"type":41},"2026-07-01",{"date":59,"type":41},"2030-07-01",{"name":5,"class":6}]