[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640927":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":64,"collaborators":26,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":26,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":26,"overallStatus":86,"whyStopped":26,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Izmir University of Economics","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Study Group","EXPERIMENTAL","Patients who will perform inspiratory muscle training (IMT) with %60 loading",[13],"Device: Inspiratory Muscle Training (IMT)",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Group","SHAM_COMPARATOR","Patients who will perform Sham IMT",[19],"Device: Sham IMT",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Inspiratory Muscle Training (IMT)","The IMT protocol will consist of home-based high-intensity daily training - two cycles of 30 breaths with a 1-min rest between sets, twice a day for 8 weeks using an IMT Threshold device (Threshold IMT Philips® Respironics, Inc). The intensity of the training will be set to 60% of each patient's maximal inspiratory pressure, measured and adjusted weekly based on the modified Borg scale from 4 to 6 regarding respiratory effort performed during the session.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham IMT","The IMT protocol will consist of home-based daily training - two cycles of 30 breaths with a 1-min rest between sets, twice a day for 8 weeks using an IMT Threshold device (Threshold IMT Philips® Respironics, Inc). The intensity of the training will be set to the lowest intensity of the IMT Threshold device.",[15],[32],{"name":33,"affiliation":34,"role":35},"Rıdvan Aktan, Assoc Prof.","İzmir University of Economics","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","+905453318172","ridvanaktan@gmail.com",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Nilay Danış, Assoc Prof.","+90 2324123704","nilaydanis17@gmail.com",[46],{"facility":5,"status":26,"city":47,"state":48,"zip":49,"country":50,"countryCode":26,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Izmir","Balçova","35330","Turkey (Türkiye)",{"type":52,"coordinates":53},"Point",[54,55],27.13838,38.41273,{"lat":55,"lon":54},[58,60,62],{"name":33,"role":38,"phone":59,"phoneExt":26,"email":40},"+902324888579",{"name":42,"role":61,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"name":63,"role":61,"phone":26,"phoneExt":26,"email":26},"Caner Bektaş, MD",{"type":35,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ridvan Aktan","Assoc. Prof., PhD","100640927","effect-of-inspiratory-muscle-training-on-symptom-severity-and-quality-of-life-in-non-erosive-reflux-disease-100640927",false,"NCT07584096","Effect of Inspiratory Muscle Training on Symptom Severity and Quality of Life in Non-Erosive Reflux Disease","Effect of Inspiratory Muscle Training on Clinical Symptom Severity and Quality of Life in Patients With Non-erosive Reflux Disease: A Randomized Controlled Trial","Inclusion Criteria:\n\n* A clinical diagnosis of NERD,\n* No erosive lesions on endoscopy,\n* Presence of reflux symptoms for at least 3 months.\n\nExclusion Criteria:\n\n* Current use of proton pump inhibitors (PPIs) or failure to complete a minimum 2-week washout period before enrollment.\n* With known gastroduodenal ulcers\n* Diagnosed with erosive esophagitis\n* With hiatal hernia\n* With a history of gastrointestinal malignancy\n* With infectious or inflammatory gastrointestinal diseases\n* With malabsorption syndrome or gastrointestinal obstruction\n* With a history of major gastrointestinal surgery (including anti-reflux, gastric, or duodenal surgery)\n* With systemic sclerosis or other systemic connective tissue diseases\n* With severe cardiovascular, pulmonary, renal, or hepatic disease\n* With chronic respiratory diseases such as asthma or COPD\n* Having had an acute respiratory tract infection within the past 4 weeks\n* With neuromuscular diseases\n* With active tuberculosis\n* Pregnancy","ALL","18 Years","65 Years",{"count":78,"type":79},60,"ESTIMATED","INTERVENTIONAL",[82],"NA","The goal of this clinical trial is to learn if inspiratory muscle training (IMT) works to treat on clinical symptom severity and quality of life in patients with Non-erosive reflux disease (NERD). The main questions it aims to answer are:\n\nDoes drug IMT lower the clinical symptom severity ? Does drug IMT improve quality of life? Researchers will compare high intensity IMT to a sham-IMT (a IMT device with no resistance) to see if IMT lower the clinical symptom severity and improve improve quality of life.\n\nParticipants will perform the following protocol:\n\nThe IMT protocol will consist of home-based high-intensity training using a Threshold IMT device: two sets of 30 breaths with a 1-minute rest, twice daily for 4 weeks. The study group will train at 60% of baseline maximum inspiratory pressure (MIP), with weekly adjustments based on modified Borg scores (4-6), while the control group will perform sham IMT without resistance.",[85],"Non-erosive Reflux Disease (NERD)","NOT_YET_RECRUITING","2026-06-23",{"date":89,"type":90},"2026-06-24","ACTUAL",{"date":92,"type":79},"2026-07-22",{"date":94,"type":79},"2027-05-15",{"name":5,"class":6},1]