[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633450":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":35,"centralContacts":35,"locations":35,"responsibleParty":48,"collaborators":35,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":35,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":77,"whyStopped":35,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":35},{"fullName":5,"class":6},"European University of Lefke","OTHER",[8,15,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"TruNatomy + AH Plus","EXPERIMENTAL","Name: TruNatomy + AH Plus Type: Experimental\n\nIntervention:\n\nDevice: TruNatomy file system Other: AH Plus sealer",[13,14],"Device: TruNatomy","Other: AH Plus",{"label":16,"type":10,"description":17,"interventionNames":18},"TruNatomy + TotalFill BC","Name: TruNatomy + TotalFill BC Type: Experimental\n\nIntervention:\n\nDevice: TruNatomy Other: TotalFill BC",[13,19],"Other: TotalFill BC",{"label":21,"type":10,"description":22,"interventionNames":23},"ProTaper Gold + AH Plus","Name: ProTaper Gold + AH Plus Type: Experimental\n\nIntervention:\n\nDevice: ProTaper Gold Other: AH Plus",[24,14],"Device: ProTaper Gold",{"label":26,"type":10,"description":27,"interventionNames":28},"ProTaper Gold + TotalFill BC","Name: ProTaper Gold + TotalFill BC Type: Experimental\n\nIntervention:\n\nDevice: ProTaper Gold Other: TotalFill BC",[24,19],[30,36,40,44],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"DEVICE","TruNatomy","Rotary nickel-titanium (NiTi) endodontic file system used for root canal shaping with minimally invasive design. Instrumentation performed according to manufacturer instructions.",[9,16],null,{"type":31,"name":37,"description":38,"armGroupLabels":39,"otherNames":35},"ProTaper Gold","Heat-treated rotary nickel-titanium (NiTi) endodontic file system used for root canal shaping following manufacturer-recommended protocol.",[21,26],{"type":6,"name":41,"description":42,"armGroupLabels":43,"otherNames":35},"AH Plus","Epoxy resin-based root canal sealer used for obturation with gutta-percha using a single-cone technique.",[21,9],{"type":6,"name":45,"description":46,"armGroupLabels":47,"otherNames":35},"TotalFill BC","Calcium silicate-based bioceramic root canal sealer used for obturation with gutta-percha using a single-cone technique.",[26,16],{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"PRINCIPAL_INVESTIGATOR","Mohamad Abduljalil","Asst. Prof. Dr. Mohamad Abduljalil","100633450","effect-of-instrumentation-systems-and-sealers-on-postoperative-pain-100633450",false,"NCT07526844","Effect of Instrumentation Systems and Sealers on Postoperative Pain","Impact of TruNatomy and ProTaper Gold Ni-Ti Systems Using Resin-based or Bioceramic Sealers on Postoperative Pain After Root Canal Treatment: a Randomized Clinical Trial","POP","Inclusion Criteria\n\n* Asymptomatic teeth with delayed positive response to thermal and electric pulp testing\n* Vital teeth with signs of irreversible pulpitis\n* Mature mandibular first or second premolars\n* Periodontally healthy teeth Exclusion Criteria\n* Patients with systemic conditions (e.g., diabetes, immunocompromised status, pregnancy)\n* Antibiotic use within the past month\n* Use of analgesics within 7 days prior to treatment\n* Known allergy to materials used\n* Teeth with periapical lesions\n* Non-vital or symptomatic teeth\n* Teeth requiring post-core restorations\n* Calcified canals, root resorption, or immature teeth","ALL","18 Years","60 Years",{"count":64,"type":65},144,"ESTIMATED","INTERVENTIONAL",[68],"NA","The goal of this randomized clinical trial is to evaluate whether different root canal preparation systems and sealer types affect postoperative pain after root canal treatment in adult patients (18-60 years) with asymptomatic irreversible pulpitis in mandibular premolars.\n\nThe main questions it aims to answer are:\n\nDo different instrumentation systems (TruNatomy vs ProTaper Gold) influence postoperative pain levels? Do different sealer types (AH Plus vs TotalFill BC) affect postoperative pain and analgesic consumption? Researchers will compare TruNatomy and ProTaper Gold systems combined with AH Plus or TotalFill BC sealers to determine their effect on postoperative pain.\n\nParticipants will:\n\nUndergo single-visit root canal treatment using one of the assigned file system and sealer combinations Record their pain levels using a Numerical Rating Scale (NRS) at specific time intervals (6, 12, 24, 48, 72 hours, and 7 days) Take ibuprofen only if needed and record analgesic intake Attend a follow-up visit on the 7th day",[71],"Irriversible Pulpitis",[73,74,75,76],"Post Operative Pain","Irreversible Pulpitis","NiTi File","Canal Sealer","NOT_YET_RECRUITING","2026-04-15",{"date":80,"type":81},"2026-04-21","ACTUAL",{"date":83,"type":65},"2026-07-01",{"date":85,"type":65},"2027-10-30",{"name":5,"class":6}]