[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620133":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":11,"responsibleParty":35,"collaborators":11,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":11,"eligibilityCriteria":43,"healthyVolunteers":39,"sex":44,"minAge":45,"maxAge":11,"enrollmentInfo":46,"targetDuration":11,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":58,"whyStopped":11,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":11},{"fullName":5,"class":6},"Xijing Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intermittent Enteral Nutrition Group","EXPERIMENTAL",null,[13],"Behavioral: Intermittent Enteral Feeding",{"label":15,"type":16,"description":11,"interventionNames":17},"Continuous Enteral Nutrition Group","ACTIVE_COMPARATOR",[18],"Behavioral: Continuous Enteral Feeding",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"BEHAVIORAL","Intermittent Enteral Feeding","Participants randomized to this group will receive enteral nutrition via a nasogastric or nasojejunal tube using an intermittent, daytime-only feeding schedule designed to align with the physiological circadian rhythm.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Continuous Enteral Feeding","Participants randomized to this group will receive enteral nutrition via a nasogastric or nasojejunal tube using the standard, continuous 24-hour feeding method commonly employed in critical care settings.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Jingjing Zhao","CONTACT","18192829590","zhaojing@126.com",{"type":36,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100620133","effect-of-intermittent-enteral-feeding-in-severe-stroke-100620133",false,"NCT07353658","Effect of Intermittent Enteral Feeding in Severe Stroke","The Effect of Intermittent Versus Continuous Enteral Feeding on Outcomes in Severe Stroke: An Exploratory Study","Inclusion Criteria:\n\n1. Age ≥18 years old\n2. It was definitely diagnosed as acute stroke by clinical imaging.\n3. Enteral nutrition program can be started within 72 hours of onset.\n4. Baseline GCS≤12 or NIHSS≥11\n5. There is nutritional risk (NRS 2002≥3), Wadian drinking water test≥ 3 or there is consciousnessdisorder,it is estimated that you need to receive nutritional support treatment for ≥7 days\n6. Obtain informed consent\n\nExclusion Criteria:\n\n1. Before joining the group, he had received total parenteral nutrition treatment.\n2. There are contraindications to enteral nutrition.\n3. Unstable vital signs\n4. Dementia or severe disability before onset (mRS≥3)\n5. There are concomitant diseases that will interfere with outcome evaluation and\u002For follow-up.\n6. Participating in other interventional clinical trials.\n7. Other circumstances in which the study cannot be completed.","ALL","18 Years",{"count":47,"type":48},60,"ESTIMATED","INTERVENTIONAL",[51],"NA","This is a single-center, randomized, exploratory clinical trial investigating whether intermittent enteral feeding improves outcomes compared to continuous feeding in patients with severe stroke. The study will enroll 60 patients to evaluate the impact on 90-day all-cause mortality, neurological function, nutritional status, and safety. It will also explore underlying mechanisms through analysis of metabolic profiles, circadian gene expression, and gut microbiota.",[54,55],"Severe Stroke","Enteral Nutrition",[57,55],"Stroke","NOT_YET_RECRUITING","2026-01-11",{"date":61,"type":62},"2026-01-20","ACTUAL",{"date":64,"type":48},"2026-01-05",{"date":66,"type":48},"2026-12-31",{"name":5,"class":6}]