[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622052":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":52,"collaborators":26,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":26,"overallStatus":75,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Salbutamol Group","EXPERIMENTAL","Participants in this arm will receive intraoperative salbutamol administration in addition to standard general anesthesia and mechanical ventilation during laparoscopic bariatric surgery.",[13],"Drug: Salbutamol (Ventolin®)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","PLACEBO_COMPARATOR","Participants in this arm will receive intraoperative administration of normal saline (0.9% sodium chloride) via the respiratory circuit, in addition to standard general anesthesia and mechanical ventilation during laparoscopic bariatric surgery.",[19],"Drug: Normal Saline (0.9% Sodium Chloride)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Salbutamol (Ventolin®)","Salbutamol will be administered intraoperatively via the respiratory circuit during mechanical ventilation to assess its effect on mechanical power and respiratory mechanics.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Normal Saline (0.9% Sodium Chloride)","Normal saline will be administered intraoperatively via the respiratory circuit in the same volume and manner as salbutamol to serve as a placebo",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"hülya tosun söner","CONTACT","+905352792102","hulyatosunsoner@hotmail.com",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":26,"country":42,"countryCode":26,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Health Sciences University Gazi Yaşargil Training and Research Hospital","Kayapınar","Diyarbakır","Turkey (Türkiye)",{"type":44,"coordinates":45},"Point",[46,47],40.17756,37.93733,{"lat":47,"lon":46},[50],{"name":33,"role":34,"phone":51,"phoneExt":26,"email":36},"05352792102",{"type":53,"investigatorFullName":54,"investigatorTitle":5,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Hülya Tosun Söner","100622052","effect-of-intraoperative-salbutamol-administration-on-mechanical-power-and-respiratory-mechanics-in-obese-patients-undergoing-laparoscopic-bariatric-surgery-100622052",false,"NCT07378605","Effect of Intraoperative Salbutamol Administration on Mechanical Power and Respiratory Mechanics in Obese Patients Undergoing Laparoscopic Bariatric Surgery","Bariatric","Inclusion Criteria:\n\n* Age: 18-65 years\n\nBMI ≥35 kg\u002Fm² (candidates for obesity surgery)\n\nScheduled for elective laparoscopic bariatric surgery\n\nASA physical status I-III\n\nSigned informed consent\n\nExclusion Criteria:\n\nKnown allergy or contraindication to salbutamol\n\nSevere cardiovascular disease (e.g., recent MI, uncontrolled arrhythmia)\n\nPre-existing severe pulmonary disease (e.g., severe COPD, asthma exacerbation)\n\nPregnancy or lactation\n\nEmergency surgery\n\nUse of β-agonists or bronchodilators within 24 hours prior to surgery\n\nPatients with inability to provide informed consent\n\n\\-",true,"ALL","18 Years","65 Years",{"count":67,"type":68},66,"ESTIMATED","INTERVENTIONAL",[71],"NA","The primary objective of this study is to evaluate the effect of intraoperative salbutamol administration on mechanical power in obese patients undergoing laparoscopic bariatric surgery under general anesthesia. Mechanical power will be measured at predefined intraoperative time points (T0, T1, and T2), and changes over time will be compared to determine the impact of salbutamol on the overall energy delivered to the respiratory system during mechanical ventilation.\n\nSecondary objectives include the assessment of intraoperative respiratory mechanics, including peak airway pressure (Ppeak), plateau pressure (Pplat), driving pressure (Pdrive), airway resistance (Raw), and lung compliance, as well as gas exchange parameters (SpO₂, EtCO₂) and hemodynamic variables (mean arterial pressure). Postoperative pulmonary outcomes will be evaluated using the Melbourne Group Scale (MGS), with a score greater than 4 indicating the presence of postoperative pulmonary complications. The study aims to investigate whether improvement in intraoperative mechanical power and respiratory mechanics is associated with a reduction in postoperative pulmonary complications in this high-risk population.",[74],"Bariatric Surgery","NOT_YET_RECRUITING","2026-01-22",{"date":78,"type":79},"2026-01-30","ACTUAL",{"date":81,"type":68},"2026-01-01",{"date":83,"type":68},"2026-03-15",{"name":5,"class":6},1]