[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552500":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":36,"locations":46,"responsibleParty":64,"collaborators":40,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":40,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":40,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":40,"overallStatus":49,"whyStopped":40,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Assaf-Harofeh Medical Center","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ketalar","ACTIVE_COMPARATOR","All patients will undergo general anesthesia using Fentanyl at a dose of 2 mcg\u002Fkg, Rocuronium at a dose of 0.6 mg\u002Fkg, Isoflurane during surgery and Remifentanil at a dose of 0.2-0.25 mcg\u002Fkg\u002Fmin, 30 Minutes before the end of the operation, Morphine will be given at a dose of 0.1 mg\u002Fkg. Each patient will receive paracetamol during surgery.\n\nIn addition to the general anesthesia, the patients in the Ketalar group will also receive a bolus of Ketalar at a dose of 0.3 mg\u002Fkg in induction + Propofol and Fentanyl and during the operation, continuous Ketalar at a dose of 5 mcg\u002Fkg\u002Fminute.",[13],"Drug: Ketalar",{"label":15,"type":10,"description":16,"interventionNames":17},"Dexmedetomidine","In addition to the general anesthesia, the patients in the Dexmedetomidine group will also receive a bolus of Ketalar at a dose of 0.3 mg\u002Fkg in induction + Propofol and Fentanyl and during the operation, continuous Ketalar at a dose of 5 mcg\u002Fkg\u002Fminute.\n\nIn addition to the general anesthesia, the patients in the Dexmedetomidine group will also receive a bolus of Dexmedetomidine at a dose of 0.5 mg\u002Fkg for fifteen minutes + Propofol and Fentanyl, and during the operation, continuous Dexmedetomidine at a dose of 0.3 mcg\u002Fkg\u002Fhour.",[18],"Drug: Dexmedetomidine",[20,26],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","a dissociative anesthetic used medically for induction and maintenance of anesthesia",[9],[25],"Ketamine",{"type":21,"name":15,"description":27,"armGroupLabels":28,"otherNames":29},"an agonist of α2-adrenergic receptors in certain parts of the brain used for sedation",[15],[30],"Precedex",[32],{"name":33,"affiliation":34,"role":35},"Sara Bar Yehuda, PhD","Shamir (Asaf Harofe) medical center","STUDY_DIRECTOR",[37,42],{"name":33,"role":38,"phone":39,"phoneExt":40,"email":41},"CONTACT","972528981004",null,"sarabar1@shamir.gov.il",{"name":43,"role":38,"phone":44,"phoneExt":40,"email":45},"Zoya Haitov Ben Zikri, MD","972537346186","ZoyaC@shamir.gov.il",[47],{"facility":48,"status":49,"city":50,"state":40,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Shamir (Asaf Harofe) Medical Center","RECRUITING","Be’er Ya‘aqov","70300","Israel","IL",{"type":55,"coordinates":56},"Point",[57,58],34.83749,31.93864,{"lat":58,"lon":57},[61,63],{"name":33,"role":38,"phone":39,"phoneExt":40,"email":62},"sarabar1@shamur.gov.il",{"name":43,"role":38,"phone":44,"phoneExt":40,"email":45},{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":40,"oldOrganization":40},"PRINCIPAL_INVESTIGATOR","Zoya Haitov Ben Zikri","Manager of the anesthesia unit","100552500","effect-of-ketalar-or-dexmedetomidine-on-increased-sensitivity-to-pain-following-treatment-with-remifentanil-100552500",false,"NCT06473896","Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Following Treatment With Remifentanil","Comparison of the Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Induced Following Treatment With Remifentanil in Patients Undergoing a Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n• Patients who are about to undergo alaparoscopic cholecystectomy under general anesthesia\n\nExclusion Criteria:\n\n* Patients with sensitivity to the anesthetic\n* Patients with chronic pain who are in regular treatment\n* Urgent surgery\n* Patients with ischemic heart disease\n* Patients with known bradycardia\n* Patients with a pacemaker\n* Prolonged use of opiates\n* Kidney\u002Fliver function problems","ALL","18 Years","85 Years",{"count":79,"type":80},90,"ESTIMATED","INTERVENTIONAL",[83],"NA","Analgesia is one of the pillars of anesthesia. One of the common opiates for pain relief, with a short half-life, is Remifentanil. However, following Remifentanil treatment an increased sensitivity to pain \\[hyperalgesia\\] appears. The aim of the study is to compare the effects between complementary treatments, like Ketalar and Dexmedetomidine, in preventing increased sensitivity to pain after Remifentanil treatment",[86],"Cholecystectomy","2024-08-05",{"date":89,"type":90},"2024-08-07","ACTUAL",{"date":92,"type":90},"2024-04-18",{"date":94,"type":80},"2026-08-30",{"name":5,"class":6},1]