[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567695":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":58,"collaborators":26,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":26,"eligibilityCriteria":67,"healthyVolunteers":64,"sex":68,"minAge":69,"maxAge":26,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Saint Petersburg State University, Russia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PMMA arm","EXPERIMENTAL","Patients in the experimental group will receive maintenance hemodialysis using polymetilmethacrylate membranes for 2 months.",[13],"Device: Polymethylmethacrylate membrane",{"label":15,"type":16,"description":17,"interventionNames":18},"Polysulfone arm","ACTIVE_COMPARATOR","Patients in the control group will receive maintenance hemodialysis using polysulfone membranes for 2 months.",[19],"Device: polysulfone membranes",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Polymethylmethacrylate membrane","A polymethylmethacrylate hollow fiber membrane (PMMA membrane) has unique properties including the uniform structure and the adsorption property.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"polysulfone membranes","Dialyzers containing polysulfone membranes are widely used for modern dialysis therapies as they allow efficient removal of a broad spectrum of uremic toxins.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Ekaterina Parshina, PhD","CONTACT","+7(921)6577372","pannn@yandex.ru",[38],{"facility":39,"status":40,"city":41,"state":26,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Saint Petersburg State University Hospital","RECRUITING","Saint Petersburg","198103","Russia","RU",{"type":46,"coordinates":47},"Point",[48,49],30.31413,59.93863,{"lat":49,"lon":48},[52,55],{"name":53,"role":34,"phone":54,"phoneExt":26,"email":36},"Ekaterina PARSHINA, PhD","89216577372",{"name":56,"role":34,"phone":26,"phoneExt":26,"email":57},"Alexey Tolkach, MD","ab2769@mail.ru",{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Ekaterina Parshina","Chief of Nephrology and Dialysis department","100567695","effect-of-kidney-replacement-therapy-with-polymethylmethacrylate-membranes-on-pruritus-related-quality-of-life-in-patients-receiving-maintenance-haemodialysis-100567695",false,"NCT06671535","Effect of Kidney Replacement Therapy with Polymethylmethacrylate Membranes on Pruritus-related Quality of Life in Patients Receiving Maintenance Haemodialysis","Inclusion Criteria:\n\n* Diagnosis of CKD stage 5D, maintenance hemodialysis not less than 3 months prior screening;\n* Moderate-to-severe pruritis (WI-NRS score ≥ 4);\n* Adequate dialysis dose (spKt\u002FV≥1,4 and\u002For eKt\u002FV≥1,2);\n* Dialysis treatment regimen: three sessions per week of at least 4 hours duration;\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Presence of active skin disease, cholestasis, severe secondary hyperparathyroidism and other conditions that, in the investigator's opinion, may be responsible for pruritus.\n* Noncompliance of the patient with the protocol (in the investigator's opinion).\n* Use of haemodiafiltration.","ALL","18 Years",{"count":71,"type":72},62,"ESTIMATED","INTERVENTIONAL",[75],"NA","This randomized controlled trial aims to evaluate the effect of polymethylmethacrylate dialysis membranes use on the intensity of pruritus in patients with CKD stage 5D receiving maintenance hemodialysis.\n\nThe main question it aims to answer is: Does the use of polymethylmethacrylate (PMMA) membranes reduce the intensity of pruritus in dialysis patients?\n\nResearchers will compare PMMA membranes to standard polysulfone-based membranes to see if PMMA works to reduce moderate-to-severe pruritis and pruritis-related quality of life.\n\nParticipants will:\n\n* receive maintenance hemodialysis with PMMA or polysulfone membranes for 2 months;\n* fill in questionnaires about intensity of pruritis and its impact on daily life.",[78,79,80],"CKD (Chronic Kidney Disease) Stage 5D","Hemodialysis","Pruritis",[82,83,84],"polymethylmethacrylate membranes","CKD-associated pruritis","PMMA membranes","2025-03-02",{"date":87,"type":88},"2025-03-04","ACTUAL",{"date":90,"type":88},"2025-01-27",{"date":92,"type":72},"2025-10",{"name":5,"class":6},1]