[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521433":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":58,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":29,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":29,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":39,"whyStopped":29,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Chung Shan Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Lactobacillus johnsonii,","PLACEBO_COMPARATOR","heat-killed Lactobacillus johnsonii TCI250",[13],"Dietary Supplement: Lactobacillus johnsonii, Placebo Comparator: White pomegranate extract",{"label":15,"type":16,"description":17,"interventionNames":18},"White pomegranate extract","EXPERIMENTAL","White pomegranate extract, dosage of 500mg",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Lactobacillus johnsonii, Placebo Comparator: White pomegranate extract","Group A: Placebo; Group B: heat-killed Lactobacillus johnsonii TCI250; Group C: White pomegranate extract, dosage of 500mg for 8 weeks.",[9,15],[26,27,28],"Group A: Placebo","Group B: heat-killed Lactobacillus johnsonii TCI250","Group C: White pomegranate extract",null,[31],{"name":32,"role":33,"phone":34,"phoneExt":29,"email":35},"Shih-Chien Huang","CONTACT","+886424730022","schuang@csmu.edu.tw",[37],{"facility":38,"status":39,"city":40,"state":29,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Chung Shan Medical University Hospital","RECRUITING","Taichung","40201","Taiwan","TW",{"type":45,"coordinates":46},"Point",[47,48],120.6839,24.1469,{"lat":48,"lon":47},[51],{"name":52,"role":33,"phone":34,"phoneExt":53,"email":35},"Shih-Chien Huang, assistant professor","12009",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Shih Chien Huang","assistant professor",[59],{"name":60,"class":61},"TCI Co., Ltd.","INDUSTRY","100521433","effect-of-lactobacillus-johnsonii-or-white-pomegranate-extract-on-the-vaginal-health-100521433",false,"NCT06069531","Effect of Lactobacillus Johnsonii or White Pomegranate Extract on the Vaginal Health","Effect of Oral Probiotic Heat-killed Lactobacillus Johnsonii TCI250 or White Pomegranate Extract on the Vaginal Flora","Inclusion Criteria:\n\n1. Females aged 20-45\n2. Nugent score ≥ 4\n3. Menstrual cycle of 28-60 days\n\nExclusion Criteria:\n\n1. Pregnant or lactating women\n2. Antibiotic usage\n3. Other reproductive-related inflammatory diseases (e.g., candidiasis, gonorrhea, chlamydia infection)\n4. Allergy to probiotics or White Pomegranate-related components","FEMALE","20 Years","45 Years",{"count":73,"type":74},150,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this clinical trial is to explore the effect of Lactobacillus johnsonii and white pomegranate extract on female bacterial status, it aims to answer are:\n\n* Evaluate Lactobacillus johnsonii TCI250 probiotics or white pomegranate extract in regulating female vaginal bacteria and improving vaginal health.\n* Evaluate Lactobacillus johnsonii TCI250 probiotics or white pomegranate extract in regulating inflammation.\n\nParticipants will be randomly assigned to placebo (n = 50), probiotic heat-killed Lactobacillus johnsonii TCI250 group (n = 50) and white pomegranate extract group (n = 50) for 8 weeks. Researchers will compare the vaginal flora and inflammation.",[80,81],"Vaginitis Bacterial","Inflammation, Ear",[83,84,85,86,87],"Bacterial Vaginitis","Probiotics","white pomegranate extract","Inflammation","Vaginal flora","2025-05-12",{"date":90,"type":91},"2025-05-14","ACTUAL",{"date":93,"type":91},"2022-04-04",{"date":95,"type":74},"2025-12-31",{"name":5,"class":6},1]