[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639931":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":22,"responsibleParty":40,"collaborators":7,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":58,"studyType":59,"phases":7,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":70,"whyStopped":7,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Northern Jiangsu People's Hospital","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Guo-Qing Jiang, MD","Clinical Medical College of Yangzhou University","STUDY_CHAIR",[14,18],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},"CONTACT","+8651487373272","jgqing2003@hotmail.com",{"name":19,"role":15,"phone":20,"phoneExt":7,"email":21},"Dou-Sheng Bai, MD","+8651487373372","bdsno1@hotmail.com",[23],{"facility":11,"status":7,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Yangzhou","Jiangsu","225001","China","CN",{"type":30,"coordinates":31},"Point",[32,33],119.43583,32.39722,{"lat":33,"lon":32},[36,37,38],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},{"name":19,"role":15,"phone":20,"phoneExt":7,"email":21},{"name":10,"role":39,"phone":7,"phoneExt":7,"email":7},"SUB_INVESTIGATOR",{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Guo-Qing Jiang","Clinical Professor","100639931","effect-of-laparoscopic-splenectomy-on-renal-function-in-cirrhotic-patients-with-hypersplenism-2-year-follow-up-100639931",false,"NCT07585773","Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)","A Prospective, Single-Center, Observational Cohort Study to Evaluate the Short-Term and Long-Term (2-Year) Effects of Laparoscopic Splenectomy on Renal Function in Patients With Liver Cirrhosis, Splenomegaly and Hypersplenism","LS-RF","Inclusion Criteria:\n\n1. Confirmed diagnosis of liver cirrhosis (clinical, laboratory, imaging)\n2. Splenomegaly and hypersplenism\n3. No history of portal hypertension bleeding (esophageal and gastric variceal bleeding )\n4. Age 18-80 years, male or female\n5. Child-Pugh Class A or B liver function\n6. No history of primary renal disease or acute kidney injury (AKI)\n7. Signed written informed consent\n8. Ability to complete 24-month follow-up\n\nExclusion Criteria:\n\n1. Child-Pugh Class C liver cirrhosis\n2. Primary renal diseases (glomerulonephritis, polycystic kidney disease, chronic pyelonephritis, etc.)\n3. Previous abdominal surgery precluding safe laparoscopic splenectomy\n4. Severe cardiac, pulmonary, cerebrovascular dysfunction; malignant tumors; primary hematological disorders\n5. Cirrhotic complications (portal hypertension bleeding, hepatic encephalopathy, refractory ascites) within 1 month before surgery\n6. Pregnancy or lactation\n7. Poor compliance, inability to complete follow-up","ALL","18 Years","80 Years",{"count":56,"type":57},30,"ESTIMATED","2 Years","OBSERVATIONAL","Patients with liver cirrhosis often have impaired or at-risk kidney function due to the close link between liver and kidney (hepatorenal syndrome). Laparoscopic splenectomy is commonly used to treat splenomegaly and hypersplenism in these patients, but its impact on kidney function over 2 years is unclear. This study will follow patients undergoing laparoscopic splenectomy to measure changes in kidney function before and after surgery, identify risk factors for kidney damage and whether laparoscopic splenectomy can improve kidney function in the long term, and help improve care to protect kidney function in cirrhotic patients .",[62,63,64,65],"Cirrhosis","Splenectomy; Status","Hypersplenism","Kidney Function Issue",[62,67,68,69,64],"Portal Hypertension","Splenectomy","Laparoscopy","NOT_YET_RECRUITING","2026-05-14",{"date":73,"type":74},"2026-05-18","ACTUAL",{"date":76,"type":57},"2026-05-01",{"date":78,"type":57},"2029-02-28",{"name":5,"class":6},1]