[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631199":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":31,"responsibleParty":57,"collaborators":26,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":26,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":34,"whyStopped":26,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Baghdad","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"arm 1 Study group A","EXPERIMENTAL","Participants receive local application of 1% metformin gel in the implant osteotomy site immediately prior to implant placement. Implant stability and peri-implant bone density will be assessed during the follow-up period.",[13],"Drug: Metformin gel, 1%",{"label":15,"type":16,"description":17,"interventionNames":18},"arm 2 Control group B","ACTIVE_COMPARATOR","Participants undergo standard implant placement without any local pharmacological application in the osteotomy site. Implant stability and peri-implant bone density will be assessed during the same follow-up period.",[19],"Other: Standard Implant Placement",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Metformin gel, 1%","A 1% metformin gel is locally applied directly into the implant osteotomy site immediately prior to implant placement. The gel is confined to the surgical site and is not systemically administered. This protocol is designed to evaluate the localized effect of metformin on implant stability and peri-implant bone density during the healing period.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Standard Implant Placement","Implant placement performed following the standard surgical protocol without any local pharmacological application in the osteotomy site.",[15],[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"University of Baghdad -Collage of Dentistry","RECRUITING","Baghdad","Baghdad Governorate","10001","Iraq","IQ",{"type":41,"coordinates":42},"Point",[43,44],44.40088,33.34058,{"lat":44,"lon":43},[47,52,54],{"name":48,"role":49,"phone":50,"phoneExt":26,"email":51},"Ghadah Kareem M.S.c. Candidate, B.D.S.","CONTACT","+9647736704817","ghada.Obaid2408m@codental.uobaghdad.edu.iq",{"name":53,"role":49,"phone":50,"phoneExt":26,"email":51},"jubori, B.D.S.",{"name":55,"role":56,"phone":26,"phoneExt":26,"email":26},"Ghada K Jbouri, B.D.S.","PRINCIPAL_INVESTIGATOR",{"type":56,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ghada Kareem","MSc student, Department of Oral and Maxillofacial surgery","100631199","effect-of-local-application-of-1-metformin-gel-on-implant-stability-and-peri-implant-bone-density-a-randomized-controlled-study-100631199",false,"NCT07497568","Effect of Local Application of 1% Metformin Gel on Implant Stability and Peri-implant Bone Density: A Randomized Controlled Study","Effect of Local Application of 1% Metformin Gel on Implant Stability and Peri-implant Bone Density: A Randomized Controlled Clinical Study","Inclusion Criteria:\n\n* 1\\) Patients age at least 18 years old. 2) Patient with partial edentulous teeth bounded areas that need dental implant for teeth replacement.\n\n  3\\) Adequate bone volume for implant placement (at least 5 mm width - 10 mm height).\n\n  4\\) Ability to tolerate conventional surgical and restorative procedures. 5) Patients who are willing to comply the study and give their consent.\n\nExclusion Criteria:\n\n\\- 1) Active infection or inflammation in the implant zone. 2) Presence of any uncontrolled systemic diseases. 3) Patient with history of chemotherapy or radiotherapy. 4) Patient had undergone bone grafting and soft tissue procedures prior to implant surgery.\n\n5\\) Patient had undergone tooth extraction at the implant site less than 6 months prior to implant surgery.","ALL","18 Years","70 Years",{"count":71,"type":72},34,"ESTIMATED","INTERVENTIONAL",[75],"NA","This randomized controlled clinical study aims to evaluate the effect of local application of 1% metformin gel on implant stability and peri-implant bone density. Patients requiring dental implants will be randomly allocated into two groups: a control group and a test group receiving metformin gel. Implant stability will be assessed using resonance frequency analysis, and bone density will be evaluated using CBCT imaging. The outcomes will be compared over a follow-up period to determine the effectiveness of metformin in enhancing osseointegration",[78,79],"Dental Implant","Stability",[81,82,83,84,85],"dental implant","CBCT","Metformin","bone density","RFA","2026-03-23",{"date":88,"type":89},"2026-03-27","ACTUAL",{"date":91,"type":89},"2025-11-01",{"date":93,"type":72},"2027-06-01",{"name":5,"class":6},1]