[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583995":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":35,"centralContacts":45,"locations":51,"responsibleParty":68,"collaborators":35,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":35,"eligibilityCriteria":75,"healthyVolunteers":72,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":35,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":54,"whyStopped":35,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Shanghai Zhongshan Hospital","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Short-term continuous normal meal replacement intervention group","PLACEBO_COMPARATOR","The normal meal replacement intake is calculated at 25kcal\u002Fkg body weight per person per day, with the calorie ratio for breakfast, lunch and dinner being 1:2:2. A meal replacement diet is given for 2 consecutive weeks.",[13],"Dietary Supplement: Short-term continuous normal meal replacement",{"label":15,"type":16,"description":17,"interventionNames":18},"Short-term continuous low valine meal replacement intervention group","EXPERIMENTAL","The low valine meal replacement intake is calculated at 25kcal\u002Fkg body weight per person per day, with the calorie ratio for breakfast, lunch and dinner being 1:2:2. A meal replacement diet is given for 2 consecutive weeks.",[19],"Dietary Supplement: Short-term continuous low-valine meal replacements",{"label":21,"type":10,"description":22,"interventionNames":23},"Long-term intermittent normal meal replacement intervention group","The normal meal replacement intake was calculated at 25 kcal\u002Fkg body weight per person per day, with the calorie distribution ratio of 1:2:2 for breakfast, lunch and dinner. A meal replacement diet was used for 2 consecutive days per week for 16 consecutive weeks.",[24],"Dietary Supplement: Long-term intermittent normal meal replacement",{"label":26,"type":16,"description":27,"interventionNames":28},"Long-term intermittent low valine meal replacement intervention group","The low valine meal replacement intake was calculated at 25 kcal\u002Fkg body weight per person per day, with the calorie distribution ratio of 1:2:2 for breakfast, lunch and dinner. A meal replacement diet was used for 2 consecutive days per week for 16 consecutive weeks.",[29],"Dietary Supplement: Long-term intermittent low valine meal replacement",[31,36,39,42],{"type":32,"name":33,"description":11,"armGroupLabels":34,"otherNames":35},"DIETARY_SUPPLEMENT","Short-term continuous normal meal replacement",[9],null,{"type":32,"name":37,"description":17,"armGroupLabels":38,"otherNames":35},"Short-term continuous low-valine meal replacements",[15],{"type":32,"name":40,"description":22,"armGroupLabels":41,"otherNames":35},"Long-term intermittent normal meal replacement",[21],{"type":32,"name":43,"description":27,"armGroupLabels":44,"otherNames":35},"Long-term intermittent low valine meal replacement",[26],[46],{"name":47,"role":48,"phone":49,"phoneExt":35,"email":50},"Mingfeng Xia","CONTACT","+86 136 1182 6871","xia.mingfeng@zs-hospital.sh.cn",[52],{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Zhongshan Hospital, Fudan University","RECRUITING","Shanghai","Shanghai Municipality","200031","China","CN",{"type":61,"coordinates":62},"Point",[63,64],121.45806,31.22222,{"lat":64,"lon":63},[67],{"name":47,"role":48,"phone":49,"phoneExt":35,"email":50},{"type":69,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR","100583995","effect-of-low-valine-diet-on-body-weight-and-metabolic-parameters-100583995",false,"NCT06883578","Effect of Low Valine Diet on Body Weight and Metabolic Parameters","Inclusion Criteria:\n\n* Male or female, 16 years old ≤ age ≤ 80 years old;\n* BMI ≥ 24kg\u002Fm2\n\nExclusion Criteria:\n\n* Excessive drinkers (defined as: in the past 6 months, the weekly alcohol intake of men exceeds 140g, and that of women exceeds 70g);\n* Liver diseases caused by other reasons: such as alcoholic liver disease, acute and chronic viral hepatitis, drug-induced, immune hepatitis (AMA, SMA, ANA), cirrhosis, liver cancer, etc.;\n* Other diseases that affect glucose and lipid metabolism: hyperthyroidism, hypothyroidism, Cushing's syndrome, etc.;\n* Poorly controlled diabetic patients: HbA1c \\>9.5% within three months; or use of hypoglycemic drugs that may affect weight, including pioglitazone, GLP-1, SGLT2 inhibitors;\n* Chronic kidney disease or severe renal impairment, defined as serum creatinine greater than 2.0mg\u002FdL;\n* Serum ALT greater than 3 times the upper limit of normal;\n* Life expectancy of no more than 3 years in the presence of serious health conditions;\n* Those who plan to get pregnant in the near future;\n* Those who cannot participate in the follow-up of the intervention due to other conditions;\n* Continuously used drugs that may cause weight changes for more than 2 weeks in the past year (such as glucocorticoids, thyroid hormones, etc.);\n* Participated in other clinical trials in the past 4 weeks;\n* Those who had gastric volume reduction surgery or digestive tract surgery;\n* Those diagnosed with any tumor disease;\n* Subjects who participated in strenuous exercise or planned to change their diet structure;\n* Unable to sign the informed consent form.","ALL","16 Years","80 Years",{"count":80,"type":81},48,"ESTIMATED","INTERVENTIONAL",[84],"NA","This study aimed to explore the effects of ordinary meal replacements and low-valine meal replacements on the weight and risk of related metabolic diseases in overweight\u002Fobese patients through a randomized double-blind controlled clinical trial.",[87,88,89],"Overweight\u002Fobesity","Metabolic Associated Fatty Liver Disease","Metabolic Diseases",[91,92,93],"Obesity","Dietary intervention","Low valine meal replacement","2025-03-15",{"date":96,"type":97},"2025-03-19","ACTUAL",{"date":99,"type":97},"2025-02-18",{"date":101,"type":81},"2026-04-30",{"name":5,"class":6},1]